Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 1524100..1524774 | Replicon | chromosome |
| Accession | NZ_AP025160 | ||
| Organism | Acidithiobacillus ferrooxidans strain NFP31 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | B7JBN6 |
| Locus tag | ANFP_RS07925 | Protein ID | WP_009564531.1 |
| Coordinates | 1524355..1524774 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | B7JBN5 |
| Locus tag | ANFP_RS07920 | Protein ID | WP_012536752.1 |
| Coordinates | 1524100..1524354 (+) | Length | 85 a.a. |
Genomic Context
Location: 1520918..1522378 (1461 bp)
Type: Others
Protein ID: WP_012536750.1
Type: Others
Protein ID: WP_012536750.1
Location: 1522382..1523926 (1545 bp)
Type: Others
Protein ID: WP_012536751.1
Type: Others
Protein ID: WP_012536751.1
Location: 1524100..1524354 (255 bp)
Type: Antitoxin
Protein ID: WP_012536752.1
Type: Antitoxin
Protein ID: WP_012536752.1
Location: 1524355..1524774 (420 bp)
Type: Toxin
Protein ID: WP_009564531.1
Type: Toxin
Protein ID: WP_009564531.1
Location: 1524771..1525004 (234 bp)
Type: Others
Protein ID: WP_226833825.1
Type: Others
Protein ID: WP_226833825.1
Location: 1525004..1525159 (156 bp)
Type: Others
Protein ID: WP_012536753.1
Type: Others
Protein ID: WP_012536753.1
Location: 1525839..1527458 (1620 bp)
Type: Others
Protein ID: WP_012536754.1
Type: Others
Protein ID: WP_012536754.1
Location: 1527549..1528748 (1200 bp)
Type: Others
Protein ID: WP_012536755.1
Type: Others
Protein ID: WP_012536755.1
Location: 1519775..1520737 (963 bp)
Type: Others
Protein ID: WP_012607230.1
Type: Others
Protein ID: WP_012607230.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ANFP_RS07905 (ANFP_15880) | 1519775..1520737 | - | 963 | WP_012607230.1 | glycosyltransferase family 2 protein | - |
| ANFP_RS07910 (ANFP_15900) | 1520918..1522378 | + | 1461 | WP_012536750.1 | IMP dehydrogenase | - |
| ANFP_RS07915 (ANFP_15910) | 1522382..1523926 | + | 1545 | WP_012536751.1 | glutamine-hydrolyzing GMP synthase | - |
| ANFP_RS07920 (ANFP_15920) | 1524100..1524354 | + | 255 | WP_012536752.1 | plasmid stabilization protein | Antitoxin |
| ANFP_RS07925 (ANFP_15930) | 1524355..1524774 | + | 420 | WP_009564531.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| ANFP_RS07930 (ANFP_15940) | 1524771..1525004 | + | 234 | WP_226833825.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| ANFP_RS07935 (ANFP_15950) | 1525004..1525159 | + | 156 | WP_012536753.1 | hypothetical protein | - |
| ANFP_RS07940 (ANFP_15960) | 1525839..1527458 | + | 1620 | WP_012536754.1 | APC family permease | - |
| ANFP_RS07945 (ANFP_15970) | 1527549..1528748 | + | 1200 | WP_012536755.1 | glutamate 5-kinase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14968.11 Da Isoelectric Point: 4.7051
>T39963 WP_009564531.1 NZ_AP025160:1524355-1524774 [Acidithiobacillus ferrooxidans]
MIVLDTNVVSEAMKPEPDAAVRAWLNEQAAETLYLSSVTLAELLFGIRALPAGKCKNMLDRALTELLELFKDRVLPFDTD
AARHYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVTVINPWKDA
MIVLDTNVVSEAMKPEPDAAVRAWLNEQAAETLYLSSVTLAELLFGIRALPAGKCKNMLDRALTELLELFKDRVLPFDTD
AARHYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVTVINPWKDA
Download Length: 420 bp
>T39963 NZ_AP025160:1524355-1524774 [Acidithiobacillus ferrooxidans]
ATGATCGTCCTGGATACCAACGTCGTTTCCGAGGCGATGAAGCCGGAGCCAGACGCGGCCGTGAGGGCTTGGCTGAACGA
ACAGGCGGCGGAAACCTTGTATCTGTCGAGCGTCACGCTGGCCGAGTTGCTGTTCGGCATCCGGGCGCTGCCGGCGGGCA
AGTGCAAGAACATGCTCGACCGCGCCCTGACCGAACTGCTGGAGCTGTTCAAGGATCGGGTGCTGCCCTTCGATACGGAT
GCAGCGCGCCACTATGCCGACCTGGCCGTGACGGCCAAGAACGGCGGGCGCGGCTTCCCGACGCCAGACGGCTACATCGC
GGCTGTTGCCGCATCGCGGGGCTTCATCGTGGCATCACGCGACACGTCGCCCTATGAAGCGGCCGGCGTGACCGTCATCA
ATCCCTGGAAGGATGCATGA
ATGATCGTCCTGGATACCAACGTCGTTTCCGAGGCGATGAAGCCGGAGCCAGACGCGGCCGTGAGGGCTTGGCTGAACGA
ACAGGCGGCGGAAACCTTGTATCTGTCGAGCGTCACGCTGGCCGAGTTGCTGTTCGGCATCCGGGCGCTGCCGGCGGGCA
AGTGCAAGAACATGCTCGACCGCGCCCTGACCGAACTGCTGGAGCTGTTCAAGGATCGGGTGCTGCCCTTCGATACGGAT
GCAGCGCGCCACTATGCCGACCTGGCCGTGACGGCCAAGAACGGCGGGCGCGGCTTCCCGACGCCAGACGGCTACATCGC
GGCTGTTGCCGCATCGCGGGGCTTCATCGTGGCATCACGCGACACGTCGCCCTATGAAGCGGCCGGCGTGACCGTCATCA
ATCCCTGGAAGGATGCATGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9225.67 Da Isoelectric Point: 10.7239
>AT39963 WP_012536752.1 NZ_AP025160:1524100-1524354 [Acidithiobacillus ferrooxidans]
MAILTVRNVPDDVHRALRVRAARHGRSTEAEVREILAAAVKPSSRVCMGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LRFD
MAILTVRNVPDDVHRALRVRAARHGRSTEAEVREILAAAVKPSSRVCMGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LRFD
Download Length: 255 bp
>AT39963 NZ_AP025160:1524100-1524354 [Acidithiobacillus ferrooxidans]
ATGGCAATCCTGACTGTAAGAAATGTGCCGGATGACGTGCATCGCGCTTTGCGCGTGCGGGCGGCCCGGCACGGTCGCAG
CACGGAAGCGGAGGTGCGCGAGATTCTGGCGGCTGCGGTCAAACCTTCGAGCCGCGTGTGCATGGGGGAAGCCCTGGCCG
CCATCGGCCGCAAGATCGGTCTGACCAATGAAGATTTCGCCGTTTTCGAGAGTGTGCGCGACAAGACGCCGGCCAAACCG
TTGCGCTTCGACTGA
ATGGCAATCCTGACTGTAAGAAATGTGCCGGATGACGTGCATCGCGCTTTGCGCGTGCGGGCGGCCCGGCACGGTCGCAG
CACGGAAGCGGAGGTGCGCGAGATTCTGGCGGCTGCGGTCAAACCTTCGAGCCGCGTGTGCATGGGGGAAGCCCTGGCCG
CCATCGGCCGCAAGATCGGTCTGACCAATGAAGATTTCGCCGTTTTCGAGAGTGTGCGCGACAAGACGCCGGCCAAACCG
TTGCGCTTCGACTGA