Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/DUF1778(antitoxin) |
| Location | 1380634..1381397 | Replicon | chromosome |
| Accession | NZ_AP025160 | ||
| Organism | Acidithiobacillus ferrooxidans strain NFP31 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | B7J9L5 |
| Locus tag | ANFP_RS07165 | Protein ID | WP_009565062.1 |
| Coordinates | 1380634..1381128 (-) | Length | 165 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | B7J9L6 |
| Locus tag | ANFP_RS07170 | Protein ID | WP_012536505.1 |
| Coordinates | 1381125..1381397 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ANFP_RS07130 (ANFP_14330) | 1376399..1377181 | + | 783 | WP_012607057.1 | ATP-binding protein | - |
| ANFP_RS07135 (ANFP_14340) | 1377174..1378016 | + | 843 | WP_012536503.1 | Hsp33 family molecular chaperone HslO | - |
| ANFP_RS07145 (ANFP_14350) | 1378734..1379240 | - | 507 | WP_009569577.1 | type II toxin-antitoxin system YhaV family toxin | - |
| ANFP_RS07150 (ANFP_14360) | 1379237..1379566 | - | 330 | WP_009569578.1 | type II toxin-antitoxin system PrlF family antitoxin | - |
| ANFP_RS07155 | 1379853..1379996 | + | 144 | WP_009569579.1 | hypothetical protein | - |
| ANFP_RS07160 (ANFP_14370) | 1380023..1380289 | - | 267 | WP_012536504.1 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| ANFP_RS07165 (ANFP_14380) | 1380634..1381128 | - | 495 | WP_009565062.1 | GNAT family N-acetyltransferase | Toxin |
| ANFP_RS07170 (ANFP_14390) | 1381125..1381397 | - | 273 | WP_012536505.1 | DUF1778 domain-containing protein | Antitoxin |
| ANFP_RS07175 (ANFP_14400) | 1381478..1381690 | - | 213 | WP_009562915.1 | hypothetical protein | - |
| ANFP_RS07180 (ANFP_14410) | 1381858..1382070 | - | 213 | WP_041645801.1 | hypothetical protein | - |
| ANFP_RS07185 (ANFP_14430) | 1382474..1383295 | - | 822 | WP_012536506.1 | UDP-2,3-diacylglucosamine diphosphatase | - |
| ANFP_RS07190 (ANFP_14440) | 1383536..1383781 | + | 246 | WP_009568482.1 | DUF2934 domain-containing protein | - |
| ANFP_RS07195 (ANFP_14450) | 1383928..1385112 | + | 1185 | WP_225487432.1 | glycosyltransferase family 1 protein | - |
| ANFP_RS07200 (ANFP_14460) | 1385146..1386360 | + | 1215 | WP_012536508.1 | glycosyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 165 a.a. Molecular weight: 18013.83 Da Isoelectric Point: 10.4415
>T39962 WP_009565062.1 NZ_AP025160:c1381128-1380634 [Acidithiobacillus ferrooxidans]
MSLKLSAPQPLAAVHLLGDFESGEPALDEWLKRRAMNNQLTGASRTFVVVDEENRVRGFYAMAAGAVAHQVATSSVRRNM
PDPVPVMVLGRLAVDSRAQGIKLGAAMLQDAVKRAITVSQNTGVRALLVHALHERAKQFYEHYGFQESPQHPMTLMLRLN
SIKA
MSLKLSAPQPLAAVHLLGDFESGEPALDEWLKRRAMNNQLTGASRTFVVVDEENRVRGFYAMAAGAVAHQVATSSVRRNM
PDPVPVMVLGRLAVDSRAQGIKLGAAMLQDAVKRAITVSQNTGVRALLVHALHERAKQFYEHYGFQESPQHPMTLMLRLN
SIKA
Download Length: 495 bp
>T39962 NZ_AP025160:c1381128-1380634 [Acidithiobacillus ferrooxidans]
ATGAGTTTGAAGCTATCCGCGCCGCAGCCACTTGCGGCCGTGCACCTGTTGGGCGACTTCGAGAGCGGTGAGCCTGCACT
GGATGAGTGGTTAAAACGCCGGGCGATGAACAACCAGCTCACCGGGGCCAGTCGAACCTTTGTGGTCGTTGATGAAGAAA
ATCGGGTGCGCGGCTTCTACGCCATGGCGGCTGGCGCAGTCGCACATCAAGTGGCGACTAGCTCGGTTCGTCGCAATATG
CCCGATCCGGTTCCCGTCATGGTGCTCGGTAGGTTGGCGGTGGATAGTCGAGCGCAAGGCATCAAGCTGGGGGCGGCCAT
GCTGCAGGACGCGGTGAAACGTGCCATCACCGTATCGCAGAACACGGGGGTTCGTGCACTGCTGGTTCATGCGCTCCACG
AACGCGCCAAACAGTTCTATGAGCACTACGGCTTTCAGGAGTCACCACAACATCCGATGACGCTGATGTTGCGCCTGAAT
AGCATCAAGGCTTGA
ATGAGTTTGAAGCTATCCGCGCCGCAGCCACTTGCGGCCGTGCACCTGTTGGGCGACTTCGAGAGCGGTGAGCCTGCACT
GGATGAGTGGTTAAAACGCCGGGCGATGAACAACCAGCTCACCGGGGCCAGTCGAACCTTTGTGGTCGTTGATGAAGAAA
ATCGGGTGCGCGGCTTCTACGCCATGGCGGCTGGCGCAGTCGCACATCAAGTGGCGACTAGCTCGGTTCGTCGCAATATG
CCCGATCCGGTTCCCGTCATGGTGCTCGGTAGGTTGGCGGTGGATAGTCGAGCGCAAGGCATCAAGCTGGGGGCGGCCAT
GCTGCAGGACGCGGTGAAACGTGCCATCACCGTATCGCAGAACACGGGGGTTCGTGCACTGCTGGTTCATGCGCTCCACG
AACGCGCCAAACAGTTCTATGAGCACTACGGCTTTCAGGAGTCACCACAACATCCGATGACGCTGATGTTGCGCCTGAAT
AGCATCAAGGCTTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10071.52 Da Isoelectric Point: 5.0914
>AT39962 WP_012536505.1 NZ_AP025160:c1381397-1381125 [Acidithiobacillus ferrooxidans]
MRAAAINLRALPEQRDLIDHAANLLGKNRSDFMLEAACERAQSVLLDQVFFGLDAEKFRQFTAMLDAPPRGNEGLERLMA
VKAPWESNQA
MRAAAINLRALPEQRDLIDHAANLLGKNRSDFMLEAACERAQSVLLDQVFFGLDAEKFRQFTAMLDAPPRGNEGLERLMA
VKAPWESNQA
Download Length: 273 bp
>AT39962 NZ_AP025160:c1381397-1381125 [Acidithiobacillus ferrooxidans]
ATGCGTGCCGCTGCCATCAATTTACGAGCCTTGCCGGAGCAGCGTGATCTCATTGATCACGCCGCCAACCTGTTAGGCAA
AAACCGTTCGGACTTCATGCTGGAAGCCGCCTGCGAGCGTGCGCAATCGGTACTGCTCGATCAGGTGTTTTTTGGGCTGG
ATGCGGAAAAGTTCCGGCAGTTCACCGCCATGCTCGACGCACCGCCTCGTGGCAACGAAGGTCTTGAGCGTCTGATGGCA
GTCAAGGCGCCATGGGAAAGCAATCAAGCATGA
ATGCGTGCCGCTGCCATCAATTTACGAGCCTTGCCGGAGCAGCGTGATCTCATTGATCACGCCGCCAACCTGTTAGGCAA
AAACCGTTCGGACTTCATGCTGGAAGCCGCCTGCGAGCGTGCGCAATCGGTACTGCTCGATCAGGTGTTTTTTGGGCTGG
ATGCGGAAAAGTTCCGGCAGTTCACCGCCATGCTCGACGCACCGCCTCGTGGCAACGAAGGTCTTGAGCGTCTGATGGCA
GTCAAGGCGCCATGGGAAAGCAATCAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|