Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 499852..500492 Replicon chromosome
Accession NZ_AP025160
Organism Acidithiobacillus ferrooxidans strain NFP31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ANFP_RS02695 Protein ID WP_009567232.1
Coordinates 500082..500492 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID B7J4M0
Locus tag ANFP_RS02690 Protein ID WP_009567231.1
Coordinates 499852..500082 (+) Length 77 a.a.

Genomic Context

ANFP_RS02675ANFP_RS02680ANFP_RS02685ANFP_RS02690ANFP_RS02695ANFP_RS02700ANFP_RS02705ANFP_RS02710ANFP_RS02715
Location: 495730..496860 (1131 bp)
Type: Others
Protein ID: WP_012536159.1
Location: 496860..497825 (966 bp)
Type: Others
Protein ID: WP_009567244.1
Location: 497826..499643 (1818 bp)
Type: Others
Protein ID: WP_012536160.1
Location: 499852..500082 (231 bp)
Type: Antitoxin
Protein ID: WP_009567231.1
Location: 500082..500492 (411 bp)
Type: Toxin
Protein ID: WP_009567232.1
Location: 500625..501723 (1099 bp)
Type: Others
Protein ID: WP_012606567.1
Location: 501763..503250 (1488 bp)
Type: Others
Protein ID: WP_229129796.1
Location: 503247..504491 (1245 bp)
Type: Others
Protein ID: WP_012536161.1
Location: 504484..505179 (696 bp)
Type: Others
Protein ID: WP_009566877.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ANFP_RS02675 (ANFP_05280)495730..496860+1131WP_012536159.1threonine synthase-
ANFP_RS02680 (ANFP_05290)496860..497825+966WP_009567244.1hypothetical protein-
ANFP_RS02685 (ANFP_05300)497826..499643+1818WP_012536160.1DHHA1 domain-containing protein-
ANFP_RS02690 (ANFP_05310)499852..500082+231WP_009567231.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
ANFP_RS02695 (ANFP_05320)500082..500492+411WP_009567232.1type II toxin-antitoxin system VapC family toxinToxin
ANFP_RS02700 (ANFP_05330)500625..501723+1099WP_012606567.1peptide chain release factor 2-
ANFP_RS02705 (ANFP_05340)501763..503250+1488WP_229129796.1lysine--tRNA ligase-
ANFP_RS02710 (ANFP_05350)503247..504491+1245WP_012536161.1lipoprotein-releasing ABC transporter permease subunit-
ANFP_RS02715 (ANFP_05360)504484..505179+696WP_009566877.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15278.46 Da        Isoelectric Point: 7.3848

>T39957 WP_009567232.1 NZ_AP025160:500082-500492 [Acidithiobacillus ferrooxidans]
MTLRYLLDTNICIYIAKHHPPAVRERFVQHGADDLAMSVITLGELCWGAEKSQARDKALASIQRLQERIQVAPLTPQVGI
HYGQIRAALESGGRPIGNNDLWIAAHARAEGWIVVTNNEREFRRVEGLQVENWVTA

Download         Length: 411 bp

>T39957 NZ_AP025160:500082-500492 [Acidithiobacillus ferrooxidans]
ATGACCTTGCGTTATCTGCTGGATACCAATATCTGCATTTATATTGCCAAACACCATCCGCCCGCCGTGCGGGAGCGTTT
TGTACAACATGGTGCCGATGATCTGGCGATGTCGGTAATCACCTTGGGTGAATTGTGTTGGGGTGCGGAAAAAAGTCAGG
CGCGTGACAAAGCGTTGGCCAGCATACAGCGCCTGCAAGAACGTATTCAGGTGGCCCCCCTCACCCCTCAGGTCGGCATC
CACTATGGCCAGATCCGCGCGGCTCTGGAAAGCGGCGGGCGGCCCATTGGCAATAATGATCTGTGGATCGCCGCACACGC
CCGCGCCGAAGGCTGGATCGTAGTTACCAACAATGAACGAGAGTTCCGACGGGTGGAAGGATTGCAAGTGGAAAACTGGG
TAACGGCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.76 Da        Isoelectric Point: 4.4217

>AT39957 WP_009567231.1 NZ_AP025160:499852-500082 [Acidithiobacillus ferrooxidans]
MAIARIFQSGNSQAVRLPKEFRFEVDQVEIFRRGNEIILREHPVDGTGVFDALADLPEDFMSDGRQDIPPQARENF

Download         Length: 231 bp

>AT39957 NZ_AP025160:499852-500082 [Acidithiobacillus ferrooxidans]
ATGGCCATCGCACGCATCTTCCAATCAGGCAACAGTCAGGCCGTACGGTTGCCCAAAGAATTCCGCTTTGAGGTGGATCA
GGTGGAAATCTTCCGCCGCGGGAATGAGATTATTCTGCGGGAGCATCCAGTGGATGGTACAGGCGTTTTTGATGCCCTGG
CCGACCTTCCCGAAGACTTCATGTCCGACGGACGCCAGGATATTCCACCCCAGGCAAGGGAAAACTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBB7J4M0

References