Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 173080..173699 Replicon chromosome
Accession NZ_AP025160
Organism Acidithiobacillus ferrooxidans strain NFP31

Toxin (Protein)


Gene name PumA Uniprot ID A0A2W1KCH5
Locus tag ANFP_RS00840 Protein ID WP_031575563.1
Coordinates 173403..173699 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ANFP_RS00835 Protein ID WP_031575560.1
Coordinates 173080..173397 (-) Length 106 a.a.

Genomic Context

ANFP_RS00810ANFP_RS00815ANFP_RS00820ANFP_RS00825ANFP_RS00830ANFP_RS00845ANFP_RS00855ANFP_RS00860ANFP_RS00865ANFP_RS00835ANFP_RS00840ANFP_RS00850
Location: 168610..169755 (1146 bp)
Type: Others
Protein ID: WP_229129756.1
Location: 169837..170577 (741 bp)
Type: Others
Protein ID: WP_054608922.1
Location: 170583..170843 (261 bp)
Type: Others
Protein ID: WP_229129757.1
Location: 170857..172551 (1695 bp)
Type: Others
Protein ID: WP_054608923.1
Location: 172622..173026 (405 bp)
Type: Others
Protein ID: WP_031575557.1
Location: 173920..174324 (405 bp)
Type: Others
Protein ID: WP_031575566.1
Location: 175387..176055 (669 bp)
Type: Others
Protein ID: WP_054608924.1
Location: 176068..177168 (1101 bp)
Type: Others
Protein ID: WP_054608925.1
Location: 177170..178174 (1005 bp)
Type: Others
Protein ID: WP_054608926.1
Location: 173080..173397 (318 bp)
Type: Antitoxin
Protein ID: WP_031575560.1
Location: 173403..173699 (297 bp)
Type: Toxin
Protein ID: WP_031575563.1
Location: 174317..175237 (921 bp)
Type: Others
Protein ID: WP_146235851.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ANFP_RS00810 (ANFP_01680)168610..169755+1146WP_229129756.1hypothetical protein-
ANFP_RS00815 (ANFP_01690)169837..170577+741WP_054608922.1P-type conjugative transfer protein TrbJ-
ANFP_RS00820 (ANFP_01700)170583..170843+261WP_229129757.1EexN family lipoprotein-
ANFP_RS00825 (ANFP_01710)170857..172551+1695WP_054608923.1P-type conjugative transfer protein TrbL-
ANFP_RS00830 (ANFP_01720)172622..173026+405WP_031575557.1hypothetical protein-
ANFP_RS00835 (ANFP_01730)173080..173397-318WP_031575560.1putative addiction module antidote proteinAntitoxin
ANFP_RS00840 (ANFP_01740)173403..173699-297WP_031575563.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ANFP_RS00845173920..174324+405WP_031575566.1hypothetical protein-
ANFP_RS00850174317..175237-921WP_146235851.1hypothetical protein-
ANFP_RS00855 (ANFP_01760)175387..176055+669WP_054608924.1type IV secretion system protein-
ANFP_RS00860 (ANFP_01770)176068..177168+1101WP_054608925.1TrbG/VirB9 family P-type conjugative transfer protein-
ANFP_RS00865 (ANFP_01780)177170..178174+1005WP_054608926.1TrbG/VirB9 family P-type conjugative transfer protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11112.88 Da        Isoelectric Point: 9.6531

>T39956 WP_031575563.1 NZ_AP025160:c173699-173403 [Acidithiobacillus ferrooxidans]
MLELIETNVFREWLEGLRDHQARARIQVRMRRLSLGNPGDVKPVGEGISEMRIDYGPGYRVYFMRRGPVVVALLCGGDKG
SQERDIALAKAIAAQWKE

Download         Length: 297 bp

>T39956 NZ_AP025160:c173699-173403 [Acidithiobacillus ferrooxidans]
ATGCTTGAGCTCATAGAAACCAACGTGTTCAGGGAATGGCTCGAAGGTCTGCGCGACCACCAAGCCCGCGCAAGGATTCA
GGTGCGGATGCGCCGATTGAGCCTTGGGAACCCTGGAGACGTGAAGCCTGTAGGTGAAGGCATCTCGGAAATGCGGATTG
ACTACGGTCCTGGCTATCGCGTCTATTTCATGAGGCGCGGACCAGTTGTGGTGGCGCTTCTGTGCGGCGGAGACAAGGGG
AGCCAGGAACGGGACATTGCTTTGGCAAAAGCCATTGCAGCGCAATGGAAGGAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11253.69 Da        Isoelectric Point: 6.2117

>AT39956 WP_031575560.1 NZ_AP025160:c173397-173080 [Acidithiobacillus ferrooxidans]
MEVQFRRYDTVNYLKTEDDIAHYLDAAMEDGDPALILAALGDVARARNLSQLARDAGMSRQGLDKALSGTGNPSLVTVLK
ITQALGLRLSFQPAHTSSHPSATGV

Download         Length: 318 bp

>AT39956 NZ_AP025160:c173397-173080 [Acidithiobacillus ferrooxidans]
ATGGAAGTGCAATTCAGACGCTACGACACCGTGAATTACCTCAAGACTGAGGACGATATTGCGCACTATCTCGATGCTGC
GATGGAGGATGGCGACCCCGCGTTGATTCTTGCAGCGCTGGGAGACGTTGCCCGTGCCCGCAACCTCAGCCAGCTCGCCC
GCGACGCAGGCATGAGCCGCCAAGGATTGGACAAGGCCCTTTCCGGAACAGGGAACCCAAGCCTGGTAACGGTGCTGAAA
ATAACCCAGGCACTCGGCCTGCGGCTTTCCTTCCAACCAGCACACACAAGCAGTCACCCATCGGCTACAGGGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2W1KCH5

Antitoxin

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Source
ID
Structure
No matching records found

References