Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 1831154..1832874 Replicon chromosome
Accession NZ_AP025158
Organism Thermus thermophilus strain TMY

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag TthTMY_RS09865 Protein ID WP_223903228.1
Coordinates 1832245..1832874 (-) Length 210 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag TthTMY_RS09860 Protein ID WP_096411141.1
Coordinates 1831154..1832236 (-) Length 361 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TthTMY_RS09835 (TthTMY_19580) 1826599..1828554 - 1956 WP_096411137.1 transketolase -
TthTMY_RS09845 (TthTMY_19590) 1828830..1829963 - 1134 WP_223903227.1 site-specific integrase -
TthTMY_RS09850 (TthTMY_19600) 1829944..1830228 - 285 WP_096411139.1 helix-turn-helix transcriptional regulator -
TthTMY_RS09855 (TthTMY_19610) 1830731..1831093 + 363 WP_096411140.1 hypothetical protein -
TthTMY_RS09860 (TthTMY_19620) 1831154..1832236 - 1083 WP_096411141.1 macro domain-containing protein Antitoxin
TthTMY_RS09865 (TthTMY_19630) 1832245..1832874 - 630 WP_223903228.1 DUF4433 domain-containing protein Toxin
TthTMY_RS09870 (TthTMY_19640) 1832908..1834350 + 1443 WP_096411142.1 site-specific DNA-methyltransferase -
TthTMY_RS09875 (TthTMY_19650) 1834358..1835455 - 1098 WP_096410490.1 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1834358..1835455 1097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(15-209)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 210 a.a.        Molecular weight: 24173.89 Da        Isoelectric Point: 9.8556

>T39954 WP_223903228.1 NZ_AP025158:c1832874-1832245 [Thermus thermophilus]
MPQQSPVYPVPTRIYHITHLENLEGILQKGGLLPQSQKPPKRQNVAYGHIQARRAEVVVPVGPRGKLHDYVPFYFCPRSP
MLYAIHTGSTEYQGGQRPILHLVSTAQRVAEERLPFVFTDRHAAVQYVRFFHKLEHLKALDWEAIRSTYWAESREKKQAE
FLVKGLFPWGLIEEIGVIDESIKAEVESVLARFPGLPHPPVRVRRSWYY

Download         Length: 630 bp

>T39954 NZ_AP025158:c1832874-1832245 [Thermus thermophilus]
ATGCCACAGCAAAGCCCGGTCTATCCGGTGCCCACGCGCATCTACCACATCACCCACCTGGAAAACCTCGAGGGCATCCT
CCAAAAGGGGGGCCTCCTCCCCCAATCCCAAAAGCCCCCCAAGCGGCAGAACGTGGCCTACGGGCACATCCAGGCCCGCC
GGGCAGAAGTCGTGGTGCCCGTGGGCCCGAGGGGCAAGCTCCACGATTACGTGCCGTTTTACTTCTGCCCCCGCTCTCCC
ATGCTCTACGCTATCCACACCGGATCTACCGAATACCAAGGGGGCCAGCGCCCCATCCTGCACCTGGTCTCCACCGCCCA
AAGGGTGGCGGAAGAGCGTCTGCCCTTCGTGTTCACCGACCGCCACGCGGCCGTTCAGTACGTTCGCTTCTTCCACAAGT
TGGAGCACCTGAAGGCTTTGGACTGGGAGGCCATTCGGTCTACTTACTGGGCCGAAAGCCGGGAGAAGAAGCAGGCCGAG
TTCCTGGTCAAGGGCCTCTTTCCCTGGGGGTTGATTGAGGAGATCGGCGTCATAGACGAGTCCATTAAGGCCGAGGTGGA
GTCCGTCCTCGCCCGGTTCCCCGGTCTACCCCATCCCCCGGTGCGGGTGCGCCGGAGTTGGTACTATTAG

Antitoxin


Download         Length: 361 a.a.        Molecular weight: 40645.03 Da        Isoelectric Point: 10.1459

>AT39954 WP_096411141.1 NZ_AP025158:c1832236-1831154 [Thermus thermophilus]
MLRFVRGDLLKAPVEALVNTVNTVGVMGKGVALQFKRAFPDNYQAYVQACKRGEVQIGRIFVHDRGPLAQPRYIFNFPTK
KHWRHPARMEYVEEGLKDLVRQIRELRVRSIALPPLGAGNGKLPWPEVKRRIQEALAPLEDVEVLVYEPPGEPQTHPIAP
QGTKPRLTPARAALLKLFGLYGALGEPLGRLEAQKLAYFLQEAGLDLRLAFVRQRFGPYAEPLNHVLVRLEGHYIRGFGD
RAGASQIRLEPQALNEAILYLADHPEADEAATRAAEWVKGFETPYGLELLATVHWVVRHEGARDWATLQKLLQTWSPRKA
TFPRTHIQVALDALLKRGALRPEEWRDRLPKPPANVAQEA

Download         Length: 1083 bp

>AT39954 NZ_AP025158:c1832236-1831154 [Thermus thermophilus]
ATGCTCCGCTTCGTACGAGGCGACCTCCTCAAAGCCCCAGTGGAAGCCCTGGTCAACACGGTGAACACCGTGGGGGTCAT
GGGCAAGGGGGTGGCCTTGCAGTTCAAGCGGGCTTTCCCGGACAACTACCAGGCCTACGTGCAGGCCTGTAAGCGGGGCG
AGGTCCAGATTGGCCGCATCTTCGTCCACGACCGGGGGCCCCTGGCCCAGCCCCGCTACATCTTCAACTTCCCCACTAAG
AAGCACTGGCGCCATCCCGCCCGCATGGAGTACGTGGAGGAGGGGCTAAAGGACCTGGTGCGCCAAATCCGGGAGCTTCG
GGTCCGCTCCATCGCCTTGCCCCCCTTGGGGGCCGGGAACGGGAAGCTTCCCTGGCCCGAGGTCAAGCGGCGCATCCAGG
AGGCCCTGGCGCCCCTCGAGGACGTGGAGGTCTTGGTCTACGAACCTCCGGGGGAACCCCAGACCCACCCCATCGCTCCC
CAAGGGACCAAGCCCCGCCTCACCCCTGCCCGGGCCGCCCTGCTCAAGCTCTTCGGCCTTTATGGGGCGCTTGGGGAACC
CTTGGGCCGCCTCGAGGCCCAAAAGCTGGCCTACTTCCTTCAGGAAGCGGGTTTGGATCTTAGGCTTGCCTTTGTCCGTC
AGCGGTTTGGCCCCTACGCCGAGCCCTTGAACCACGTGCTGGTCCGCCTCGAGGGCCACTACATCCGGGGCTTCGGAGAC
CGCGCGGGGGCTTCCCAGATACGCCTCGAGCCTCAGGCCCTGAACGAGGCCATCCTCTACTTGGCCGACCACCCTGAGGC
CGACGAGGCCGCCACCCGGGCGGCGGAATGGGTCAAGGGGTTTGAGACCCCTTATGGCTTAGAGCTTTTGGCCACGGTCC
ACTGGGTCGTGCGCCACGAAGGGGCCCGGGACTGGGCCACCCTGCAAAAGTTGCTCCAAACCTGGAGCCCCCGCAAGGCC
ACTTTTCCCCGGACCCACATTCAGGTAGCCCTGGACGCCCTCTTGAAGCGGGGGGCCCTCCGCCCCGAGGAGTGGCGGGA
CCGGCTTCCTAAACCGCCCGCCAATGTGGCCCAGGAAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References