Detailed information of TA system TA039951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 834673..835346
• Replicon: chromosome
• Accession: NZ_AP025158
• Organism: Thermus thermophilus strain TMY

Toxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: TthTMY_RS04555
• Protein ID: WP_229365148.1
• Coordinates: 834673..835065 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TthTMY_RS04560
• Protein ID: WP_223903470.1
• Coordinates: 835086..835346 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TthTMY_RS04530 (TthTMY_08970)	830266..831213	+	948	WP_096410436.1	DUF523 and DUF1722 domain-containing protein	-
TthTMY_RS04535 (TthTMY_08980)	831210..831623	-	414	WP_014630573.1	DUF86 domain-containing protein	-
TthTMY_RS04540 (TthTMY_08990)	831610..832002	-	393	WP_014511244.1	nucleotidyltransferase domain-containing protein	-
TthTMY_RS04545 (TthTMY_09000)	832012..833010	-	999	WP_096410437.1	type 2 isopentenyl-diphosphate Delta-isomerase	-
TthTMY_RS04550 (TthTMY_09010)	833007..834575	-	1569	WP_223903469.1	phytoene desaturase family protein	-
TthTMY_RS04555 (TthTMY_09020)	834673..835065	-	393	WP_229365148.1	type II toxin-antitoxin system VapC family toxin	Toxin
TthTMY_RS04560 (TthTMY_09030)	835086..835346	-	261	WP_223903470.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
TthTMY_RS04565 (TthTMY_09040)	835400..836422	-	1023	WP_223903471.1	glycosyltransferase family A protein	-
TthTMY_RS04570	836419..837090	-	672	WP_096410440.1	lysophospholipid acyltransferase family protein	-
TthTMY_RS04575 (TthTMY_09050)	837095..837793	-	699	WP_096410441.1	lycopene cyclase domain-containing protein	-
TthTMY_RS04580 (TthTMY_09060)	837790..838959	-	1170	WP_096410442.1	cytochrome P450	-
TthTMY_RS04585 (TthTMY_09070)	838969..839148	-	180	WP_096410443.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-67)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14224.61 Da
• Isoelectric Point: 10.7842

>T39951 WP_229365148.1 NZ_AP025158:c835065-834673 [Thermus thermophilus]
VVSEAVKRRPHPKVVAFLRHLKVGEAYLSALTLGELVQGVARAPEARRATLSRWLSGLKASFSGRILPLDAEVMELWGEL
TGKAMREGKPLSPLDAMLAATALRHGLTLVTRNTEDFRHVPVPLANPWEG

Nucleotide

• Length: 393 bp

>T39951 NZ_AP025158:c835065-834673 [Thermus thermophilus]
GTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCGCCACCTTAAAGTGGGGGAGGCGTA
CCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAGGCCCGAAGGGCCACCCTCAGCCGAT
GGCTCTCGGGGCTGAAGGCAAGCTTCTCGGGGCGGATCCTTCCCCTGGACGCCGAGGTGATGGAACTCTGGGGCGAGCTC
ACCGGAAAGGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGCGGCCACGGCCCTACGGCACGGCCT
GACCCTGGTCACCCGGAACACCGAGGACTTCCGCCACGTCCCCGTGCCCCTCGCGAACCCCTGGGAAGGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9864.38 Da
• Isoelectric Point: 8.5953

>AT39951 WP_223903470.1 NZ_AP025158:c835346-835086 [Thermus thermophilus]
VKAIWQLQEAKARFSEVVERALKGEPQLVLRRGKKAVVVLDWETYARLAGEEASVLEALRPPKTLPNEEVEALFQRQKTG
FREVDF

Nucleotide

• Length: 261 bp

>AT39951 NZ_AP025158:c835346-835086 [Thermus thermophilus]
GTGAAGGCCATCTGGCAACTCCAAGAGGCCAAAGCCCGCTTCTCCGAGGTGGTGGAGCGGGCCCTCAAGGGGGAGCCCCA
GCTCGTCCTCCGGCGGGGCAAGAAGGCGGTGGTGGTGCTGGACTGGGAGACCTACGCCCGCCTCGCGGGGGAAGAGGCCT
CGGTCCTCGAGGCCCTAAGACCCCCCAAGACCCTCCCCAATGAGGAGGTGGAAGCCCTCTTCCAAAGGCAAAAGACGGGC
TTCCGGGAGGTGGACTTCTGA