Detailed information of TA system TA039949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 1652311..1653077
• Replicon: chromosome
• Accession: NZ_AP025156
• Organism: Vibrio penaeicida strain TUMSAT-OK2

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A432DAA5
• Locus tag: LDO36_RS26225
• Protein ID: WP_017053840.1
• Coordinates: 1652580..1653077 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LDO36_RS26220
• Protein ID: WP_126608258.1
• Coordinates: 1652311..1652583 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO36_RS26200	1648009..1648374	-	366	WP_126608616.1	hypothetical protein	-
LDO36_RS26205	1648356..1648835	-	480	WP_126608615.1	type VI secretion system amidase effector protein Tae4	-
LDO36_RS26210	1650430..1650774	-	345	WP_126607806.1	hypothetical protein	-
LDO36_RS26215	1652109..1652201	-	93	WP_221768543.1	DUF3265 domain-containing protein	-
LDO36_RS26220	1652311..1652583	+	273	WP_126608258.1	DUF1778 domain-containing protein	Antitoxin
LDO36_RS26225	1652580..1653077	+	498	WP_017053840.1	GNAT family N-acetyltransferase	Toxin
LDO36_RS26230	1653183..1653590	+	408	WP_126608259.1	hypothetical protein	-
LDO36_RS26235	1654342..1654677	-	336	WP_126607678.1	hypothetical protein	-
LDO36_RS26240	1655028..1656139	+	1112	WP_224055502.1	IS3 family transposase	-
LDO36_RS26245	1656444..1656620	-	177	WP_224055503.1	hypothetical protein	-
LDO36_RS26250	1656629..1656907	-	279	WP_224055504.1	GNAT family N-acetyltransferase	-
LDO36_RS26255	1657040..1657423	-	384	WP_224055505.1	hypothetical protein	-
LDO36_RS26260	1657582..1658034	-	453	WP_126609048.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1630545..1742899	112354
	-	inside	Integron	-	-	1638166..1658615	20449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-89)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18458.12 Da
• Isoelectric Point: 8.8085

>T39949 WP_017053840.1 NZ_AP025156:1652580-1653077 [Vibrio penaeicida]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Nucleotide

• Length: 498 bp

>T39949 NZ_AP025156:1652580-1653077 [Vibrio penaeicida]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATTGGCTTTTACACACTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCCGGTGGTCTGATTGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9765.25 Da
• Isoelectric Point: 8.5960

>AT39949 WP_126608258.1 NZ_AP025156:1652311-1652583 [Vibrio penaeicida]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQTDAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Nucleotide

• Length: 273 bp

>AT39949 NZ_AP025156:1652311-1652583 [Vibrio penaeicida]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAACTGATGCGATGTTGCTTATGGAAGCTTTAGACCGTCCTGCGACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A432DAA5