Detailed information of TA system TA039948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1636288..1636835
• Replicon: chromosome
• Accession: NZ_AP025156
• Organism: Vibrio penaeicida strain TUMSAT-OK2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDO36_RS26120
• Protein ID: WP_126606442.1
• Coordinates: 1636288..1636590 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: LDO36_RS26125
• Protein ID: WP_005448240.1
• Coordinates: 1636578..1636835 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO36_RS26090	1633249..1633656	-	408	WP_126606447.1	hypothetical protein	-
LDO36_RS26095	1633782..1634171	-	390	WP_126606446.1	GFA family protein	-
LDO36_RS26100	1634289..1634420	-	132	Protein_1425	biphenyl 2,3-dioxygenase	-
LDO36_RS26105	1634499..1634987	-	489	WP_126606445.1	GNAT family N-acetyltransferase	-
LDO36_RS26110	1635154..1635603	-	450	WP_126606444.1	GNAT family N-acetyltransferase	-
LDO36_RS26115	1635677..1636072	-	396	WP_126606443.1	hypothetical protein	-
LDO36_RS26120	1636288..1636590	-	303	WP_126606442.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDO36_RS26125	1636578..1636835	-	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDO36_RS26130	1636996..1638106	-	1111	Protein_1431	IS3 family transposase	-
LDO36_RS26135	1638173..1638403	+	231	WP_224055500.1	hypothetical protein	-
LDO36_RS26140	1638544..1638864	-	321	WP_126606404.1	hypothetical protein	-
LDO36_RS26145	1639805..1640437	-	633	WP_126606405.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1630545..1742899	112354
	-	inside	IScluster/Tn	-	-	1630545..1638106	7561
	-	inside	Integron	-	-	1638166..1658615	20449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11650.53 Da
• Isoelectric Point: 6.9814

>T39948 WP_126606442.1 NZ_AP025156:c1636590-1636288 [Vibrio penaeicida]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSRVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
SILFVMRAERNLRKFLLSKR

Nucleotide

• Length: 303 bp

>T39948 NZ_AP025156:c1636590-1636288 [Vibrio penaeicida]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATTGT
TGCGGCAAAGCAGTTAGTACAAACGATCTTCTCCAGAGTCGAACGTCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAATTAGAGCATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TCTATTCTGTTTGTTATGCGTGCAGAGAGAAACTTGCGTAAGTTCTTGTTGAGTAAGCGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT39948 WP_005448240.1 NZ_AP025156:c1636835-1636578 [Vibrio penaeicida]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT39948 NZ_AP025156:c1636835-1636578 [Vibrio penaeicida]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAAGGTATTGCGCGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8