Detailed information of TA system TA039945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1725400..1725965
• Replicon: chromosome
• Accession: NZ_AP025153
• Organism: Vibrio penaeicida strain TUMSAT-OK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDP65_RS26700
• Protein ID: WP_104403463.1
• Coordinates: 1725400..1725687 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3NI65
• Locus tag: LDP65_RS26705
• Protein ID: WP_011080399.1
• Coordinates: 1725684..1725965 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDP65_RS26665	1721209..1721577	+	369	WP_126606400.1	hypothetical protein	-
LDP65_RS31125	1721570..1721965	+	396	WP_263422590.1	YqaJ viral recombinase family protein	-
LDP65_RS26675	1721973..1722641	+	669	WP_224164953.1	hypothetical protein	-
LDP65_RS26680	1722652..1723608	+	957	WP_126606402.1	RecT family recombinase	-
LDP65_RS26685	1723829..1724074	+	246	WP_104402999.1	excisionase	-
LDP65_RS26690	1724058..1724681	+	624	WP_224055561.1	phage integrase Arm DNA-binding domain-containing protein	-
LDP65_RS26695	1724699..1725205	+	507	WP_224055562.1	tyrosine-type recombinase/integrase	-
LDP65_RS26700	1725400..1725687	-	288	WP_104403463.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDP65_RS26705	1725684..1725965	-	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDP65_RS26710	1726368..1727324	+	957	WP_221768525.1	IS110 family transposase	-
LDP65_RS26715	1727368..1727736	-	369	WP_224055563.1	hypothetical protein	-
LDP65_RS26720	1727773..1728919	+	1147	Protein_1543	IS3 family transposase	-
LDP65_RS26725	1729587..1729928	-	342	WP_126610338.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1673271..1743073	69802

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10990.70 Da
• Isoelectric Point: 4.8129

>T39945 WP_104403463.1 NZ_AP025153:c1725687-1725400 [Vibrio penaeicida]
MKVVWSPLALQKLGDAAEFISLDNPVAAEDWVNEVFDKTELLSSMPEMGRMVPELPHTNFREIIFGHYRIIYSLSHEIRI
LTVRNCRQMLTESDV

Nucleotide

• Length: 288 bp

>T39945 NZ_AP025153:c1725687-1725400 [Vibrio penaeicida]
ATGAAAGTAGTCTGGTCACCACTAGCATTGCAAAAGTTAGGTGATGCAGCTGAATTTATTTCGTTGGACAATCCAGTAGC
AGCAGAAGATTGGGTTAATGAGGTTTTCGATAAAACGGAGCTTCTCTCAAGTATGCCGGAAATGGGTCGTATGGTGCCGG
AATTACCTCATACCAACTTTCGTGAAATTATTTTTGGGCACTATCGCATCATATATAGCCTTAGCCATGAAATTCGCATT
CTAACGGTGCGAAATTGTCGTCAAATGCTGACGGAAAGTGACGTATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10426.96 Da
• Isoelectric Point: 5.8719

>AT39945 WP_011080399.1 NZ_AP025153:c1725965-1725684 [Vibrio penaeicida]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT39945 NZ_AP025153:c1725965-1725684 [Vibrio penaeicida]
ATGAGCCGTATCCATTTCGACCAAGATATTCAGCCTTTGTCTGAATTTCGAGCTGGCGTAACGTCATTTATCAAGCAGAT
CAACGAAACTCGCAGACCACTAGTAATAACACAGCGTGGTAAAGGTGTAGCTGTTGTTCTTGATGTCGCAGAATATGAAG
CAATGCAAGAGAAGATCGAGTTACTTGAAGAAATGCGTACTGCTGAAGCACAACTAGCTTCGGGCTTAGGTGTTTCTAAT
GAGGACGCTCGTGCTCAAGTGTTAGGACGTATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0MQY5