Detailed information of TA system TA039942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1636297..1636844
• Replicon: chromosome
• Accession: NZ_AP025153
• Organism: Vibrio penaeicida strain TUMSAT-OK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDP65_RS26115
• Protein ID: WP_126606442.1
• Coordinates: 1636297..1636599 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: LDP65_RS26120
• Protein ID: WP_005448240.1
• Coordinates: 1636587..1636844 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDP65_RS26080	1631737..1632850	-	1114	Protein_1417	IS3 family transposase	-
LDP65_RS26085	1633258..1633665	-	408	WP_126606447.1	hypothetical protein	-
LDP65_RS26090	1633791..1634180	-	390	WP_126606446.1	GFA family protein	-
LDP65_RS26095	1634298..1634429	-	132	Protein_1420	biphenyl 2,3-dioxygenase	-
LDP65_RS26100	1634508..1634996	-	489	WP_126606445.1	GNAT family N-acetyltransferase	-
LDP65_RS26105	1635163..1635612	-	450	WP_126606444.1	GNAT family N-acetyltransferase	-
LDP65_RS26110	1635686..1636081	-	396	WP_126606443.1	hypothetical protein	-
LDP65_RS26115	1636297..1636599	-	303	WP_126606442.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDP65_RS26120	1636587..1636844	-	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDP65_RS26125	1637005..1638115	-	1111	Protein_1426	IS3 family transposase	-
LDP65_RS26130	1638182..1638412	+	231	WP_224055500.1	hypothetical protein	-
LDP65_RS26135	1638553..1638873	-	321	WP_126606404.1	hypothetical protein	-
LDP65_RS26140	1639814..1640446	-	633	WP_126606405.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1638175..1660808	22633
	-	inside	IScluster/Tn	-	-	1630556..1638115	7559
	-	inside	Integron	-	-	1638175..1658620	20445

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11650.53 Da
• Isoelectric Point: 6.9814

>T39942 WP_126606442.1 NZ_AP025153:c1636599-1636297 [Vibrio penaeicida]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSRVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
SILFVMRAERNLRKFLLSKR

Nucleotide

• Length: 303 bp

>T39942 NZ_AP025153:c1636599-1636297 [Vibrio penaeicida]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATTGT
TGCGGCAAAGCAGTTAGTACAAACGATCTTCTCCAGAGTCGAACGTCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAATTAGAGCATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TCTATTCTGTTTGTTATGCGTGCAGAGAGAAACTTGCGTAAGTTCTTGTTGAGTAAGCGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT39942 WP_005448240.1 NZ_AP025153:c1636844-1636587 [Vibrio penaeicida]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT39942 NZ_AP025153:c1636844-1636587 [Vibrio penaeicida]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAAGGTATTGCGCGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8