Detailed information of TA system TA039940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1665954..1666519
• Replicon: chromosome
• Accession: NZ_AP025150
• Organism: Vibrio penaeicida strain IFO 15642

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDO91_RS26135
• Protein ID: WP_104403463.1
• Coordinates: 1665954..1666241 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3NI65
• Locus tag: LDO91_RS26140
• Protein ID: WP_011080399.1
• Coordinates: 1666238..1666519 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO91_RS26105	1661244..1661579	-	336	WP_126607678.1	hypothetical protein	-
LDO91_RS26110	1661930..1663041	+	1112	WP_224055502.1	IS3 family transposase	-
LDO91_RS26115	1663346..1663522	-	177	WP_224055503.1	hypothetical protein	-
LDO91_RS26120	1663531..1663809	-	279	WP_224055504.1	GNAT family N-acetyltransferase	-
LDO91_RS26125	1663942..1664325	-	384	WP_224055505.1	hypothetical protein	-
LDO91_RS26130	1664484..1664936	-	453	WP_126609048.1	GNAT family N-acetyltransferase	-
LDO91_RS26135	1665954..1666241	-	288	WP_104403463.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDO91_RS26140	1666238..1666519	-	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDO91_RS26145	1666922..1667878	+	957	WP_221768525.1	IS110 family transposase	-
LDO91_RS26150	1667922..1668290	-	369	WP_224055563.1	hypothetical protein	-
LDO91_RS26155	1668327..1669480	+	1154	WP_224067559.1	IS3 family transposase	-
LDO91_RS26160	1670148..1670489	-	342	WP_126610338.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1661930..1680273	18343
	-	inside	Integron	-	-	1645446..1683332	37886

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10990.70 Da
• Isoelectric Point: 4.8129

>T39940 WP_104403463.1 NZ_AP025150:c1666241-1665954 [Vibrio penaeicida]
MKVVWSPLALQKLGDAAEFISLDNPVAAEDWVNEVFDKTELLSSMPEMGRMVPELPHTNFREIIFGHYRIIYSLSHEIRI
LTVRNCRQMLTESDV

Nucleotide

• Length: 288 bp

>T39940 NZ_AP025150:c1666241-1665954 [Vibrio penaeicida]
ATGAAAGTAGTCTGGTCACCACTAGCATTGCAAAAGTTAGGTGATGCAGCTGAATTTATTTCGTTGGACAATCCAGTAGC
AGCAGAAGATTGGGTTAATGAGGTTTTCGATAAAACGGAGCTTCTCTCAAGTATGCCGGAAATGGGTCGTATGGTGCCGG
AATTACCTCATACCAACTTTCGTGAAATTATTTTTGGGCACTATCGCATCATATATAGCCTTAGCCATGAAATTCGCATT
CTAACGGTGCGAAATTGTCGTCAAATGCTGACGGAAAGTGACGTATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10426.96 Da
• Isoelectric Point: 5.8719

>AT39940 WP_011080399.1 NZ_AP025150:c1666519-1666238 [Vibrio penaeicida]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT39940 NZ_AP025150:c1666519-1666238 [Vibrio penaeicida]
ATGAGCCGTATCCATTTCGACCAAGATATTCAGCCTTTGTCTGAATTTCGAGCTGGCGTAACGTCATTTATCAAGCAGAT
CAACGAAACTCGCAGACCACTAGTAATAACACAGCGTGGTAAAGGTGTAGCTGTTGTTCTTGATGTCGCAGAATATGAAG
CAATGCAAGAGAAGATCGAGTTACTTGAAGAAATGCGTACTGCTGAAGCACAACTAGCTTCGGGCTTAGGTGTTTCTAAT
GAGGACGCTCGTGCTCAAGTGTTAGGACGTATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0MQY5