Detailed information of TA system TA039939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 1659213..1659979
• Replicon: chromosome
• Accession: NZ_AP025150
• Organism: Vibrio penaeicida strain IFO 15642

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A432DAA5
• Locus tag: LDO91_RS26095
• Protein ID: WP_017053840.1
• Coordinates: 1659482..1659979 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LDO91_RS26090
• Protein ID: WP_126608258.1
• Coordinates: 1659213..1659485 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO91_RS26070	1654911..1655276	-	366	WP_126608616.1	hypothetical protein	-
LDO91_RS26075	1655258..1655737	-	480	WP_126608615.1	type VI secretion system amidase effector protein Tae4	-
LDO91_RS26080	1657332..1657676	-	345	WP_126607806.1	hypothetical protein	-
LDO91_RS26085	1659011..1659103	-	93	WP_221768543.1	DUF3265 domain-containing protein	-
LDO91_RS26090	1659213..1659485	+	273	WP_126608258.1	DUF1778 domain-containing protein	Antitoxin
LDO91_RS26095	1659482..1659979	+	498	WP_017053840.1	GNAT family N-acetyltransferase	Toxin
LDO91_RS26100	1660085..1660492	+	408	WP_126608259.1	hypothetical protein	-
LDO91_RS26105	1661244..1661579	-	336	WP_126607678.1	hypothetical protein	-
LDO91_RS26110	1661930..1663041	+	1112	WP_224055502.1	IS3 family transposase	-
LDO91_RS26115	1663346..1663522	-	177	WP_224055503.1	hypothetical protein	-
LDO91_RS26120	1663531..1663809	-	279	WP_224055504.1	GNAT family N-acetyltransferase	-
LDO91_RS26125	1663942..1664325	-	384	WP_224055505.1	hypothetical protein	-
LDO91_RS26130	1664484..1664936	-	453	WP_126609048.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1661930..1680273	18343
	-	inside	Integron	-	-	1645446..1683332	37886

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-89)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18458.12 Da
• Isoelectric Point: 8.8085

>T39939 WP_017053840.1 NZ_AP025150:1659482-1659979 [Vibrio penaeicida]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Nucleotide

• Length: 498 bp

>T39939 NZ_AP025150:1659482-1659979 [Vibrio penaeicida]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATTGGCTTTTACACACTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCCGGTGGTCTGATTGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9765.25 Da
• Isoelectric Point: 8.5960

>AT39939 WP_126608258.1 NZ_AP025150:1659213-1659485 [Vibrio penaeicida]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQTDAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Nucleotide

• Length: 273 bp

>AT39939 NZ_AP025150:1659213-1659485 [Vibrio penaeicida]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAACTGATGCGATGTTGCTTATGGAAGCTTTAGACCGTCCTGCGACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A432DAA5