Detailed information of TA system TA039936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 174247..174797
• Replicon: chromosome
• Accession: NZ_AP025150
• Organism: Vibrio penaeicida strain IFO 15642

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LDO91_RS19555
• Protein ID: WP_126606873.1
• Coordinates: 174498..174797 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LDO91_RS19550
• Protein ID: WP_126606874.1
• Coordinates: 174247..174489 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO91_RS19525	169628..170419	-	792	WP_126607934.1	4-hydroxy-2-oxoheptanedioate aldolase	-
LDO91_RS19530	170464..171267	-	804	WP_101110492.1	2-oxo-hepta-3-ene-1,7-dioic acid hydratase	-
LDO91_RS19535	171522..172031	+	510	WP_224055759.1	4-hydroxyphenylacetate 3-monooxygenase, reductase component	-
LDO91_RS19540	172082..173251	+	1170	WP_126606876.1	flavin-dependent monooxygenase	-
LDO91_RS19545	173518..173751	+	234	WP_126606875.1	hypothetical protein	-
LDO91_RS19550	174247..174489	+	243	WP_126606874.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDO91_RS19555	174498..174797	+	300	WP_126606873.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDO91_RS19560	175061..177421	+	2361	WP_126606872.1	ATP-binding protein	-
LDO91_RS19565	177472..179400	-	1929	WP_224055760.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11534.37 Da
• Isoelectric Point: 9.7638

>T39936 WP_126606873.1 NZ_AP025150:174498-174797 [Vibrio penaeicida]
MPKIKYKLSKLAQSHLRKIKDYTVANYSELQWVKYKDTLLTGFRMIADNPDLGRHCDEIYPNGFYFPLGRHTAYFTKEGD
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T39936 NZ_AP025150:174498-174797 [Vibrio penaeicida]
ATGCCAAAGATAAAATACAAGCTGAGTAAATTAGCTCAGAGTCACTTGCGCAAAATCAAGGACTATACTGTTGCCAATTA
TTCAGAATTACAGTGGGTAAAATACAAAGATACACTCCTTACTGGTTTTAGAATGATTGCCGACAATCCCGATCTTGGTA
GGCATTGTGATGAAATATACCCGAACGGATTCTACTTTCCTTTGGGGCGACACACGGCATACTTCACTAAAGAGGGCGAC
TTCATATTAGTTGTAGCCGTTCTTGGACAATCTCAGTTACCCCAGAACCATTTGAAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9029.19 Da
• Isoelectric Point: 4.5858

>AT39936 WP_126606874.1 NZ_AP025150:174247-174489 [Vibrio penaeicida]
MYTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKTDLAQNDVADGESFLNNL

Nucleotide

• Length: 243 bp

>AT39936 NZ_AP025150:174247-174489 [Vibrio penaeicida]
ATGTATACATTAACGGCCAATGATGCAAAACGTAACTTCGGTGAGCTACTTCTTAATGCTCAACGTGAGCCGATAAAGAT
CAGCAAAAACAGTAAAGACGCTGTAGTAGTTATGTCCATCAAAGACTACGAAGAACTTGAAGCGATGAAGGCTGATTATC
TTAAACATTGCTTTGAGTCCGCTAAAACCGATCTAGCCCAAAACGATGTCGCTGATGGCGAAAGCTTTCTAAACAATCTG
TAA