Detailed information of TA system TA039935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1576007..1576572
• Replicon: chromosome
• Accession: NZ_AP025148
• Organism: Vibrio penaeicida strain IFO 15641

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDO90_RS26120
• Protein ID: WP_104403463.1
• Coordinates: 1576007..1576294 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3NI65
• Locus tag: LDO90_RS26125
• Protein ID: WP_011080399.1
• Coordinates: 1576291..1576572 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO90_RS26090	1571297..1571632	-	336	WP_126607678.1	hypothetical protein	-
LDO90_RS26095	1571983..1573094	+	1112	WP_224055502.1	IS3 family transposase	-
LDO90_RS26100	1573399..1573575	-	177	WP_224055503.1	hypothetical protein	-
LDO90_RS26105	1573584..1573862	-	279	WP_224055504.1	GNAT family N-acetyltransferase	-
LDO90_RS26110	1573995..1574378	-	384	WP_224055505.1	hypothetical protein	-
LDO90_RS26115	1574537..1574989	-	453	WP_126609048.1	GNAT family N-acetyltransferase	-
LDO90_RS26120	1576007..1576294	-	288	WP_104403463.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDO90_RS26125	1576291..1576572	-	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDO90_RS26130	1576975..1577931	+	957	WP_221768525.1	IS110 family transposase	-
LDO90_RS26135	1577975..1578343	-	369	WP_224055563.1	hypothetical protein	-
LDO90_RS26140	1578380..1579534	+	1155	Protein_1373	IS3 family transposase	-
LDO90_RS26145	1580202..1580543	-	342	WP_126610338.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1571983..1590326	18343
	-	inside	Integron	-	-	1555498..1593385	37887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10990.70 Da
• Isoelectric Point: 4.8129

>T39935 WP_104403463.1 NZ_AP025148:c1576294-1576007 [Vibrio penaeicida]
MKVVWSPLALQKLGDAAEFISLDNPVAAEDWVNEVFDKTELLSSMPEMGRMVPELPHTNFREIIFGHYRIIYSLSHEIRI
LTVRNCRQMLTESDV

Nucleotide

• Length: 288 bp

>T39935 NZ_AP025148:c1576294-1576007 [Vibrio penaeicida]
ATGAAAGTAGTCTGGTCACCACTAGCATTGCAAAAGTTAGGTGATGCAGCTGAATTTATTTCGTTGGACAATCCAGTAGC
AGCAGAAGATTGGGTTAATGAGGTTTTCGATAAAACGGAGCTTCTCTCAAGTATGCCGGAAATGGGTCGTATGGTGCCGG
AATTACCTCATACCAACTTTCGTGAAATTATTTTTGGGCACTATCGCATCATATATAGCCTTAGCCATGAAATTCGCATT
CTAACGGTGCGAAATTGTCGTCAAATGCTGACGGAAAGTGACGTATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10426.96 Da
• Isoelectric Point: 5.8719

>AT39935 WP_011080399.1 NZ_AP025148:c1576572-1576291 [Vibrio penaeicida]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT39935 NZ_AP025148:c1576572-1576291 [Vibrio penaeicida]
ATGAGCCGTATCCATTTCGACCAAGATATTCAGCCTTTGTCTGAATTTCGAGCTGGCGTAACGTCATTTATCAAGCAGAT
CAACGAAACTCGCAGACCACTAGTAATAACACAGCGTGGTAAAGGTGTAGCTGTTGTTCTTGATGTCGCAGAATATGAAG
CAATGCAAGAGAAGATCGAGTTACTTGAAGAAATGCGTACTGCTGAAGCACAACTAGCTTCGGGCTTAGGTGTTTCTAAT
GAGGACGCTCGTGCTCAAGTGTTAGGACGTATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0MQY5