Detailed information of TA system TA039934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 1569266..1570032
• Replicon: chromosome
• Accession: NZ_AP025148
• Organism: Vibrio penaeicida strain IFO 15641

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A432DAA5
• Locus tag: LDO90_RS26080
• Protein ID: WP_017053840.1
• Coordinates: 1569535..1570032 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LDO90_RS26075
• Protein ID: WP_126608258.1
• Coordinates: 1569266..1569538 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO90_RS26055	1564964..1565329	-	366	WP_126608616.1	hypothetical protein	-
LDO90_RS26060	1565311..1565790	-	480	WP_126608615.1	type VI secretion system amidase effector protein Tae4	-
LDO90_RS26065	1567385..1567729	-	345	WP_126607806.1	hypothetical protein	-
LDO90_RS26070	1569064..1569156	-	93	WP_221768543.1	DUF3265 domain-containing protein	-
LDO90_RS26075	1569266..1569538	+	273	WP_126608258.1	DUF1778 domain-containing protein	Antitoxin
LDO90_RS26080	1569535..1570032	+	498	WP_017053840.1	GNAT family N-acetyltransferase	Toxin
LDO90_RS26085	1570138..1570545	+	408	WP_126608259.1	hypothetical protein	-
LDO90_RS26090	1571297..1571632	-	336	WP_126607678.1	hypothetical protein	-
LDO90_RS26095	1571983..1573094	+	1112	WP_224055502.1	IS3 family transposase	-
LDO90_RS26100	1573399..1573575	-	177	WP_224055503.1	hypothetical protein	-
LDO90_RS26105	1573584..1573862	-	279	WP_224055504.1	GNAT family N-acetyltransferase	-
LDO90_RS26110	1573995..1574378	-	384	WP_224055505.1	hypothetical protein	-
LDO90_RS26115	1574537..1574989	-	453	WP_126609048.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1571983..1590326	18343
	-	inside	Integron	-	-	1555498..1593385	37887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-89)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18458.12 Da
• Isoelectric Point: 8.8085

>T39934 WP_017053840.1 NZ_AP025148:1569535-1570032 [Vibrio penaeicida]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Nucleotide

• Length: 498 bp

>T39934 NZ_AP025148:1569535-1570032 [Vibrio penaeicida]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATTGGCTTTTACACACTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCCGGTGGTCTGATTGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9765.25 Da
• Isoelectric Point: 8.5960

>AT39934 WP_126608258.1 NZ_AP025148:1569266-1569538 [Vibrio penaeicida]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQTDAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Nucleotide

• Length: 273 bp

>AT39934 NZ_AP025148:1569266-1569538 [Vibrio penaeicida]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAACTGATGCGATGTTGCTTATGGAAGCTTTAGACCGTCCTGCGACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A432DAA5