Detailed information of TA system TA039930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 274163..275522
• Replicon: plasmid pIFO15640
• Accession: NZ_AP025146
• Organism: Vibrio penaeicida strain IFO 15640T

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: LDO37_RS30155
• Protein ID: WP_126605928.1
• Coordinates: 274569..275522 (+)
• Length: 318 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: LDO37_RS30150
• Protein ID: WP_126605929.1
• Coordinates: 274163..274567 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO37_RS30115	269163..269609	-	447	WP_126605933.1	hypothetical protein	-
LDO37_RS30120	269694..270371	+	678	WP_126605932.1	hypothetical protein	-
LDO37_RS30125	270384..271490	+	1107	WP_126605931.1	SEL1-like repeat protein	-
LDO37_RS30130	271477..272148	+	672	WP_126605930.1	hypothetical protein	-
LDO37_RS30135	272290..272985	+	696	WP_022614864.1	hypothetical protein	-
LDO37_RS30140	273024..273269	-	246	WP_022614866.1	hypothetical protein	-
LDO37_RS30145	273612..273971	+	360	WP_224056097.1	hypothetical protein	-
LDO37_RS30150	274163..274567	+	405	WP_126605929.1	DUF6088 family protein	Antitoxin
LDO37_RS30155	274569..275522	+	954	WP_126605928.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LDO37_RS30160	275542..277089	+	1548	WP_126605939.1	type I restriction-modification system subunit M	-
LDO37_RS30165	277079..278353	+	1275	WP_126605927.1	restriction endonuclease subunit S	-
LDO37_RS30170	278589..279446	+	858	WP_126605926.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	tet(B)	-	1..285021	285021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-304)

Antitoxin

• Protein of unknown function DUF6088 (9-129)

Sequences

Toxin

Protein

• Length: 318 a.a.
• Molecular weight: 36728.54 Da
• Isoelectric Point: 6.4002

>T39930 WP_126605928.1 NZ_AP025146:274569-275522 [Vibrio penaeicida]
MEKLKQQFLEVSDALELGNPAIIEKDYWVVALLSELAKVSPVYHQMVFSGGTALAKSNVKILRMSEDVDIKLIPHQEFGE
LSRGQKKAARKTCIHEIEMAITQTERFTVESRLVRDEYRYVEFELRYPQQFSQAPCLRPIIKLELIETIPLLDVEPRPIQ
SLVAELYRQPQEVKAFDCVSIHATLVEKVISMLRRTMSVKRSAERKDDVTLVRHIYDVYCILKTEGQKESFDLKALTPLF
KTVLEEDVKRFGNQHAEFVSNPKQELQLGLKELEENAIFRQRFQEFVTPMVFNTEAHDFDTCFASFKRIAASLIEKI

Nucleotide

• Length: 954 bp

>T39930 NZ_AP025146:274569-275522 [Vibrio penaeicida]
ATGGAAAAATTAAAACAACAATTTCTTGAGGTTTCCGATGCACTTGAGCTCGGAAACCCCGCCATTATTGAAAAAGATTA
CTGGGTCGTCGCCTTACTTAGCGAATTAGCGAAGGTATCGCCTGTGTATCATCAAATGGTTTTTTCTGGGGGGACTGCGC
TAGCCAAGTCAAACGTTAAAATCCTGAGAATGTCAGAAGATGTAGATATAAAGCTCATTCCCCATCAAGAATTTGGTGAG
CTGAGTCGCGGCCAAAAGAAAGCCGCCCGTAAGACATGCATTCACGAGATTGAAATGGCGATCACTCAAACAGAGCGATT
TACCGTTGAGTCGCGTCTCGTTCGTGATGAATATCGCTATGTCGAGTTTGAACTCAGATACCCGCAGCAGTTTAGCCAAG
CGCCATGTCTTCGCCCCATAATTAAACTTGAGTTAATAGAGACGATCCCTCTACTGGATGTAGAACCACGGCCGATCCAA
TCATTGGTAGCGGAACTGTATCGACAACCACAAGAAGTAAAAGCGTTTGATTGCGTCTCTATCCACGCGACCTTAGTTGA
GAAAGTGATATCAATGTTGCGCCGTACAATGTCAGTCAAGCGCAGTGCTGAGCGTAAGGATGATGTCACGCTTGTTCGCC
ATATTTATGATGTTTACTGTATTTTAAAGACCGAAGGCCAGAAAGAAAGCTTCGATCTGAAAGCACTTACACCCTTATTT
AAAACGGTGTTGGAAGAAGATGTTAAGCGTTTTGGTAATCAGCATGCAGAATTCGTCTCCAATCCAAAACAAGAGCTACA
ACTTGGCCTCAAAGAGCTTGAGGAAAATGCAATATTCCGCCAACGCTTTCAGGAATTTGTCACGCCAATGGTGTTTAACA
CCGAAGCCCATGATTTTGATACCTGCTTTGCCTCATTTAAACGCATTGCAGCATCGCTAATTGAAAAAATTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15256.56 Da
• Isoelectric Point: 10.6509

>AT39930 WP_126605929.1 NZ_AP025146:274163-274567 [Vibrio penaeicida]
MTAVERVYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVKQGELIKLGYGLYTKARMNSLTGRPMPTNPGGSDALMRE
ILKMKGVDFEMDSLSLQSLSGESTQIPSSVQYSWNPKQFNRKLVVGNRVLNSPS

Nucleotide

• Length: 405 bp

>AT39930 NZ_AP025146:274163-274567 [Vibrio penaeicida]
ATGACAGCTGTTGAACGCGTTTATCAAAAGATAAAGCGCTCAAGACGTTATGTTTTTGAGCGCAAAGACTTTGATGGTTT
TGCTAGCTACGACCAAATCGGTCGAGCGTTAAGGCAGTTAGTTAAGCAAGGTGAGTTAATCAAGCTTGGCTACGGTCTAT
ACACAAAAGCAAGAATGAATAGTCTAACCGGCAGACCCATGCCCACAAACCCTGGCGGAAGCGATGCCCTGATGCGTGAA
ATTTTAAAGATGAAAGGCGTCGATTTTGAAATGGACAGTCTATCTTTGCAAAGCTTATCAGGAGAAAGTACCCAAATCCC
ATCCTCCGTTCAATACTCATGGAACCCCAAACAGTTTAATCGCAAATTGGTTGTCGGTAACCGAGTATTAAACTCGCCGA
GTTAG