Detailed information of TA system TA039929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1665772..1666337
• Replicon: chromosome
• Accession: NZ_AP025145
• Organism: Vibrio penaeicida strain IFO 15640T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDO37_RS25805
• Protein ID: WP_104403463.1
• Coordinates: 1665772..1666059 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3NI65
• Locus tag: LDO37_RS25810
• Protein ID: WP_011080399.1
• Coordinates: 1666056..1666337 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO37_RS25775	1661060..1661395	-	336	WP_126607678.1	hypothetical protein	-
LDO37_RS25780	1661746..1662859	+	1114	Protein_1448	IS3 family transposase	-
LDO37_RS25785	1663164..1663340	-	177	WP_224055503.1	hypothetical protein	-
LDO37_RS25790	1663349..1663627	-	279	WP_224055504.1	GNAT family N-acetyltransferase	-
LDO37_RS25795	1663760..1664143	-	384	WP_224055505.1	hypothetical protein	-
LDO37_RS25800	1664302..1664754	-	453	WP_126609048.1	GNAT family N-acetyltransferase	-
LDO37_RS25805	1665772..1666059	-	288	WP_104403463.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDO37_RS25810	1666056..1666337	-	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDO37_RS25815	1666740..1667697	+	958	Protein_1455	IS110 family transposase	-
LDO37_RS25820	1667741..1668109	-	369	WP_224055563.1	hypothetical protein	-
LDO37_RS25825	1668146..1669299	+	1154	WP_224055256.1	IS3 family transposase	-
LDO37_RS25830	1669967..1670308	-	342	WP_126610338.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1661746..1680091	18345
	-	inside	Integron	-	-	1645260..1683150	37890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10990.70 Da
• Isoelectric Point: 4.8129

>T39929 WP_104403463.1 NZ_AP025145:c1666059-1665772 [Vibrio penaeicida]
MKVVWSPLALQKLGDAAEFISLDNPVAAEDWVNEVFDKTELLSSMPEMGRMVPELPHTNFREIIFGHYRIIYSLSHEIRI
LTVRNCRQMLTESDV

Nucleotide

• Length: 288 bp

>T39929 NZ_AP025145:c1666059-1665772 [Vibrio penaeicida]
ATGAAAGTAGTCTGGTCACCACTAGCATTGCAAAAGTTAGGTGATGCAGCTGAATTTATTTCGTTGGACAATCCAGTAGC
AGCAGAAGATTGGGTTAATGAGGTTTTCGATAAAACGGAGCTTCTCTCAAGTATGCCGGAAATGGGTCGTATGGTGCCGG
AATTACCTCATACCAACTTTCGTGAAATTATTTTTGGGCACTATCGCATCATATATAGCCTTAGCCATGAAATTCGCATT
CTAACGGTGCGAAATTGTCGTCAAATGCTGACGGAAAGTGACGTATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10426.96 Da
• Isoelectric Point: 5.8719

>AT39929 WP_011080399.1 NZ_AP025145:c1666337-1666056 [Vibrio penaeicida]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT39929 NZ_AP025145:c1666337-1666056 [Vibrio penaeicida]
ATGAGCCGTATCCATTTCGACCAAGATATTCAGCCTTTGTCTGAATTTCGAGCTGGCGTAACGTCATTTATCAAGCAGAT
CAACGAAACTCGCAGACCACTAGTAATAACACAGCGTGGTAAAGGTGTAGCTGTTGTTCTTGATGTCGCAGAATATGAAG
CAATGCAAGAGAAGATCGAGTTACTTGAAGAAATGCGTACTGCTGAAGCACAACTAGCTTCGGGCTTAGGTGTTTCTAAT
GAGGACGCTCGTGCTCAAGTGTTAGGACGTATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0MQY5