Detailed information of TA system TA039928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 1659029..1659795
• Replicon: chromosome
• Accession: NZ_AP025145
• Organism: Vibrio penaeicida strain IFO 15640T

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A432DAA5
• Locus tag: LDO37_RS25765
• Protein ID: WP_017053840.1
• Coordinates: 1659298..1659795 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LDO37_RS25760
• Protein ID: WP_126608258.1
• Coordinates: 1659029..1659301 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO37_RS25740	1654727..1655092	-	366	WP_126608616.1	hypothetical protein	-
LDO37_RS25745	1655074..1655553	-	480	WP_126608615.1	type VI secretion system amidase effector protein Tae4	-
LDO37_RS25750	1657148..1657492	-	345	WP_126607806.1	hypothetical protein	-
LDO37_RS25755	1658827..1658919	-	93	WP_221768543.1	DUF3265 domain-containing protein	-
LDO37_RS25760	1659029..1659301	+	273	WP_126608258.1	DUF1778 domain-containing protein	Antitoxin
LDO37_RS25765	1659298..1659795	+	498	WP_017053840.1	GNAT family N-acetyltransferase	Toxin
LDO37_RS25770	1659901..1660308	+	408	WP_126608259.1	hypothetical protein	-
LDO37_RS25775	1661060..1661395	-	336	WP_126607678.1	hypothetical protein	-
LDO37_RS25780	1661746..1662859	+	1114	Protein_1448	IS3 family transposase	-
LDO37_RS25785	1663164..1663340	-	177	WP_224055503.1	hypothetical protein	-
LDO37_RS25790	1663349..1663627	-	279	WP_224055504.1	GNAT family N-acetyltransferase	-
LDO37_RS25795	1663760..1664143	-	384	WP_224055505.1	hypothetical protein	-
LDO37_RS25800	1664302..1664754	-	453	WP_126609048.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1661746..1680091	18345
	-	inside	Integron	-	-	1645260..1683150	37890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-89)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18458.12 Da
• Isoelectric Point: 8.8085

>T39928 WP_017053840.1 NZ_AP025145:1659298-1659795 [Vibrio penaeicida]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Nucleotide

• Length: 498 bp

>T39928 NZ_AP025145:1659298-1659795 [Vibrio penaeicida]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATTGGCTTTTACACACTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCCGGTGGTCTGATTGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9765.25 Da
• Isoelectric Point: 8.5960

>AT39928 WP_126608258.1 NZ_AP025145:1659029-1659301 [Vibrio penaeicida]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQTDAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Nucleotide

• Length: 273 bp

>AT39928 NZ_AP025145:1659029-1659301 [Vibrio penaeicida]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAACTGATGCGATGTTGCTTATGGAAGCTTTAGACCGTCCTGCGACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A432DAA5