Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1659029..1659795 Replicon chromosome
Accession NZ_AP025145
Organism Vibrio penaeicida strain IFO 15640T

Toxin (Protein)


Gene name - Uniprot ID A0A432DAA5
Locus tag LDO37_RS25765 Protein ID WP_017053840.1
Coordinates 1659298..1659795 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LDO37_RS25760 Protein ID WP_126608258.1
Coordinates 1659029..1659301 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO37_RS25740 1654727..1655092 - 366 WP_126608616.1 hypothetical protein -
LDO37_RS25745 1655074..1655553 - 480 WP_126608615.1 type VI secretion system amidase effector protein Tae4 -
LDO37_RS25750 1657148..1657492 - 345 WP_126607806.1 hypothetical protein -
LDO37_RS25755 1658827..1658919 - 93 WP_221768543.1 DUF3265 domain-containing protein -
LDO37_RS25760 1659029..1659301 + 273 WP_126608258.1 DUF1778 domain-containing protein Antitoxin
LDO37_RS25765 1659298..1659795 + 498 WP_017053840.1 GNAT family N-acetyltransferase Toxin
LDO37_RS25770 1659901..1660308 + 408 WP_126608259.1 hypothetical protein -
LDO37_RS25775 1661060..1661395 - 336 WP_126607678.1 hypothetical protein -
LDO37_RS25780 1661746..1662859 + 1114 Protein_1448 IS3 family transposase -
LDO37_RS25785 1663164..1663340 - 177 WP_224055503.1 hypothetical protein -
LDO37_RS25790 1663349..1663627 - 279 WP_224055504.1 GNAT family N-acetyltransferase -
LDO37_RS25795 1663760..1664143 - 384 WP_224055505.1 hypothetical protein -
LDO37_RS25800 1664302..1664754 - 453 WP_126609048.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1661746..1680091 18345
- inside Integron - - 1645260..1683150 37890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(86-152)

Antitoxin

(2-89)


Sequences


Toxin        


Download         Length: 166 a.a.        Molecular weight: 18458.12 Da        Isoelectric Point: 8.8085

>T39928 WP_017053840.1 NZ_AP025145:1659298-1659795 [Vibrio penaeicida]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T39928 NZ_AP025145:1659298-1659795 [Vibrio penaeicida]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATTGGCTTTTACACACTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCCGGTGGTCTGATTGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9765.25 Da        Isoelectric Point: 8.5960

>AT39928 WP_126608258.1 NZ_AP025145:1659029-1659301 [Vibrio penaeicida]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQTDAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT39928 NZ_AP025145:1659029-1659301 [Vibrio penaeicida]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAACTGATGCGATGTTGCTTATGGAAGCTTTAGACCGTCCTGCGACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A432DAA5


Antitoxin

Source ID Structure

References