Detailed information of TA system TA039926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1576540..1577087
• Replicon: chromosome
• Accession: NZ_AP025145
• Organism: Vibrio penaeicida strain IFO 15640T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDO37_RS25335
• Protein ID: WP_126606442.1
• Coordinates: 1576540..1576842 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: LDO37_RS25340
• Protein ID: WP_005448240.1
• Coordinates: 1576830..1577087 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO37_RS25305	1573501..1573908	-	408	WP_126606447.1	hypothetical protein	-
LDO37_RS25310	1574034..1574423	-	390	WP_126606446.1	GFA family protein	-
LDO37_RS25315	1574541..1574672	-	132	Protein_1357	biphenyl 2,3-dioxygenase	-
LDO37_RS25320	1574751..1575239	-	489	WP_126606445.1	GNAT family N-acetyltransferase	-
LDO37_RS25325	1575406..1575855	-	450	WP_126606444.1	GNAT family N-acetyltransferase	-
LDO37_RS25330	1575929..1576324	-	396	WP_126606443.1	hypothetical protein	-
LDO37_RS25335	1576540..1576842	-	303	WP_126606442.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDO37_RS25340	1576830..1577087	-	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDO37_RS25350	1578426..1578656	+	231	WP_224055500.1	hypothetical protein	-
LDO37_RS25355	1579377..1579808	+	432	WP_224056068.1	hypothetical protein	-
LDO37_RS25360	1579809..1580351	+	543	WP_126610256.1	ImmA/IrrE family metallo-endopeptidase	-
LDO37_RS25365	1580348..1581421	+	1074	WP_126610255.1	beta family protein	-
LDO37_RS25370	1581401..1582024	-	624	WP_126610254.1	sce7726 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1570797..1582024	11227
	-	inside	IScluster/Tn	-	-	1570797..1578359	7562

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11650.53 Da
• Isoelectric Point: 6.9814

>T39926 WP_126606442.1 NZ_AP025145:c1576842-1576540 [Vibrio penaeicida]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSRVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
SILFVMRAERNLRKFLLSKR

Nucleotide

• Length: 303 bp

>T39926 NZ_AP025145:c1576842-1576540 [Vibrio penaeicida]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATTGT
TGCGGCAAAGCAGTTAGTACAAACGATCTTCTCCAGAGTCGAACGTCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAATTAGAGCATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TCTATTCTGTTTGTTATGCGTGCAGAGAGAAACTTGCGTAAGTTCTTGTTGAGTAAGCGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT39926 WP_005448240.1 NZ_AP025145:c1577087-1576830 [Vibrio penaeicida]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT39926 NZ_AP025145:c1577087-1576830 [Vibrio penaeicida]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAAGGTATTGCGCGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8