Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 4523557..4524122 Replicon chromosome
Accession NZ_AP025032
Organism Aureimonas sp. SA4125

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Sa4125_RS21390 Protein ID WP_224001469.1
Coordinates 4523557..4523874 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Sa4125_RS21395 Protein ID WP_224001471.1
Coordinates 4523868..4524122 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sa4125_RS21365 (Sa4125_42800) 4519512..4520057 + 546 WP_224001459.1 DUF934 domain-containing protein -
Sa4125_RS21370 (Sa4125_42810) 4520050..4520871 + 822 WP_224001461.1 phosphoadenylyl-sulfate reductase -
Sa4125_RS21375 (Sa4125_42820) 4520868..4521770 + 903 WP_224001463.1 sulfate adenylyltransferase subunit CysD -
Sa4125_RS21380 (Sa4125_42830) 4521772..4523409 + 1638 WP_224001465.1 sulfate adenylyltransferase subunit CysN -
Sa4125_RS21385 4523406..4523552 + 147 WP_224001467.1 hypothetical protein -
Sa4125_RS21390 (Sa4125_42840) 4523557..4523874 - 318 WP_224001469.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Sa4125_RS21395 (Sa4125_42850) 4523868..4524122 - 255 WP_224001471.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Sa4125_RS21400 (Sa4125_42860) 4524200..4524862 - 663 WP_224001473.1 OmpA family protein -
Sa4125_RS21405 (Sa4125_42870) 4525156..4526235 + 1080 WP_224001475.1 esterase-like activity of phytase family protein -
Sa4125_RS21410 (Sa4125_42880) 4526325..4527356 - 1032 WP_224001483.1 aspartate-semialdehyde dehydrogenase -
Sa4125_RS21415 (Sa4125_42900) 4527967..4528536 + 570 WP_224001485.1 DUF4142 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11675.67 Da        Isoelectric Point: 10.7114

>T39922 WP_224001469.1 NZ_AP025032:c4523874-4523557 [Aureimonas sp. SA4125]
MVKRGEIWLVALDPTFGSEIKKTRPCLVLSPDSLNRHSRVVTVAPLTSGSRPAPFRVKIQFQGVYGLVLPEQCRAVDKQR
LIRPLGTADDTALSQVLAVLRNFYT

Download         Length: 318 bp

>T39922 NZ_AP025032:c4523874-4523557 [Aureimonas sp. SA4125]
ATGGTGAAGCGCGGGGAGATCTGGCTTGTCGCTCTGGATCCAACCTTCGGCAGTGAGATCAAGAAAACCCGGCCTTGTCT
GGTCCTGTCGCCGGACAGCCTCAATCGGCATTCCCGCGTCGTCACAGTCGCTCCACTGACGTCTGGAAGCAGGCCAGCAC
CGTTTCGCGTCAAGATCCAGTTTCAGGGTGTCTACGGCCTTGTTCTGCCAGAGCAGTGTCGAGCAGTCGACAAGCAACGG
TTGATAAGACCGCTCGGAACCGCCGACGACACGGCCTTGAGCCAAGTCCTCGCGGTGCTCAGGAATTTCTATACGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8828.89 Da        Isoelectric Point: 4.1409

>AT39922 WP_224001471.1 NZ_AP025032:c4524122-4523868 [Aureimonas sp. SA4125]
MRAAVRKFGNSTGIIIPKPLLAAFGASAGDGVSLTMEAGRLVIERVDSDPQAGWAEAAEQLAAEGDDGLVWPEFGNDGDK
DLKW

Download         Length: 255 bp

>AT39922 NZ_AP025032:c4524122-4523868 [Aureimonas sp. SA4125]
ATGCGCGCAGCCGTCCGCAAATTTGGCAACTCCACGGGGATCATTATCCCGAAGCCGCTGCTGGCAGCCTTCGGTGCGTC
CGCCGGCGACGGGGTCAGCCTGACGATGGAGGCGGGGCGGCTCGTCATCGAGCGGGTTGATAGCGATCCGCAGGCGGGCT
GGGCCGAGGCAGCCGAACAGCTCGCGGCGGAAGGTGACGACGGCTTGGTCTGGCCAGAGTTCGGAAATGACGGTGACAAA
GACCTGAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References