Detailed information of TA system TA039921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4439090..4439700
• Replicon: chromosome
• Accession: NZ_AP025032
• Organism: Aureimonas sp. SA4125

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Sa4125_RS20950
• Protein ID: WP_224001295.1
• Coordinates: 4439512..4439700 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: Sa4125_RS20945
• Protein ID: WP_224001293.1
• Coordinates: 4439090..4439506 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Sa4125_RS20930 (Sa4125_41920)	4435001..4435900	+	900	WP_224008091.1	diaminopimelate epimerase	-
Sa4125_RS20935 (Sa4125_41930)	4435940..4437220	+	1281	WP_224001289.1	tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB	-
Sa4125_RS20940 (Sa4125_41940)	4437308..4439071	+	1764	WP_224001291.1	signal recognition particle-docking protein FtsY	-
Sa4125_RS20945 (Sa4125_41950)	4439090..4439506	-	417	WP_224001293.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Sa4125_RS20950 (Sa4125_41960)	4439512..4439700	-	189	WP_224001295.1	type II toxin-antitoxin system HicA family toxin	Toxin
Sa4125_RS20955 (Sa4125_41970)	4439829..4440491	+	663	WP_224001297.1	septation protein A	-
Sa4125_RS20960 (Sa4125_41980)	4440554..4441312	+	759	WP_224001299.1	tellurite resistance TerB family protein	-
Sa4125_RS20965 (Sa4125_41990)	4441432..4442205	+	774	WP_224001301.1	tellurite resistance TerB family protein	-
Sa4125_RS20970 (Sa4125_42000)	4442237..4442800	-	564	WP_224001303.1	NUDIX hydrolase	-
Sa4125_RS20975 (Sa4125_42010)	4442805..4443086	-	282	WP_224001312.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Sa4125_RS20980 (Sa4125_42020)	4443083..4443334	-	252	WP_224001315.1	type II toxin-antitoxin system ParD family antitoxin	-
Sa4125_RS20985 (Sa4125_42030)	4443395..4443997	-	603	WP_224001316.1	DsbE family thiol:disulfide interchange protein	-
Sa4125_RS20990 (Sa4125_42040)	4443994..4444164	-	171	WP_224001318.1	heme exporter protein CcmD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6845.16 Da
• Isoelectric Point: 11.2210

>T39921 WP_224001295.1 NZ_AP025032:c4439700-4439512 [Aureimonas sp. SA4125]
VDSRIILAKLLADGWIEVVRAGSHLQMKHPTKPGRVTLPHPRKDVPVGTLKSIEKQSGLKLK

Nucleotide

• Length: 189 bp

>T39921 NZ_AP025032:c4439700-4439512 [Aureimonas sp. SA4125]
GTGGACAGTCGCATCATCCTGGCGAAACTTCTCGCTGACGGCTGGATCGAAGTGGTTCGGGCGGGCAGTCATTTGCAGAT
GAAGCATCCCACAAAGCCCGGGCGGGTGACGCTGCCTCACCCGAGGAAAGACGTCCCGGTCGGCACCTTGAAGAGTATTG
AGAAGCAATCCGGGCTGAAGCTGAAGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14637.52 Da
• Isoelectric Point: 4.6401

>AT39921 WP_224001293.1 NZ_AP025032:c4439506-4439090 [Aureimonas sp. SA4125]
MTSYIAIIHKDSDSDFGVSFPDFPGCISGGRDLDEARAMAGEALALHLVGMDADGDTIPEPSSLDAVMANAANRDGVAIL
VTVPERVRKSVRVNVTFPEDTLRAIDMAAEERGLTRSGFLLESAKSAMGRKDSKRPAG

Nucleotide

• Length: 417 bp

>AT39921 NZ_AP025032:c4439506-4439090 [Aureimonas sp. SA4125]
ATGACGAGCTATATCGCCATCATCCACAAGGACTCCGACAGCGATTTCGGCGTGTCTTTTCCGGACTTTCCCGGATGCAT
CTCGGGGGGCCGCGATCTCGACGAAGCGCGCGCCATGGCCGGTGAAGCGTTGGCGCTGCACCTGGTGGGGATGGACGCGG
ACGGCGACACGATCCCCGAGCCATCGTCGCTGGACGCGGTGATGGCCAATGCCGCCAACCGGGACGGTGTCGCCATCCTC
GTCACCGTTCCGGAACGCGTCCGAAAATCCGTGCGGGTCAACGTTACCTTTCCCGAAGATACGCTTCGGGCAATCGACAT
GGCCGCCGAGGAGCGCGGTCTGACGCGGTCGGGTTTCCTCCTGGAATCGGCGAAATCGGCCATGGGCCGCAAGGACAGCA
AGCGCCCTGCCGGCTGA