Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3560080..3560711 Replicon chromosome
Accession NZ_AP025028
Organism Leptospira kobayashii strain E30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DI077_RS16130 Protein ID WP_109021321.1
Coordinates 3560307..3560711 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DI077_RS16125 Protein ID WP_109021320.1
Coordinates 3560080..3560310 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DI077_RS16085 (LPTSP3_g31760) 3555708..3555932 + 225 WP_109020912.1 DUF433 domain-containing protein -
DI077_RS16090 (LPTSP3_g31770) 3555922..3556284 + 363 WP_109020911.1 DUF5615 family PIN-like protein -
DI077_RS16095 (LPTSP3_g31780) 3556320..3556478 + 159 WP_167837173.1 hypothetical protein -
DI077_RS16100 (LPTSP3_g31810) 3557007..3557219 + 213 WP_109021317.1 hypothetical protein -
DI077_RS16105 (LPTSP3_g31820) 3557252..3557530 + 279 WP_109022133.1 type II toxin-antitoxin system RelE/ParE family toxin -
DI077_RS16110 (LPTSP3_g31830) 3557530..3557826 + 297 WP_109021318.1 HigA family addiction module antitoxin -
DI077_RS16115 (LPTSP3_g31840) 3558004..3558645 + 642 WP_109021319.1 hypothetical protein -
DI077_RS16120 (LPTSP3_g31860) 3559156..3559362 + 207 WP_100736135.1 toxin-antitoxin system, antitoxin component -
DI077_RS16125 (LPTSP3_g31870) 3560080..3560310 + 231 WP_109021320.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DI077_RS16130 (LPTSP3_g31880) 3560307..3560711 + 405 WP_109021321.1 type II toxin-antitoxin system VapC family toxin Toxin
DI077_RS16135 (LPTSP3_g31890) 3560819..3561667 + 849 WP_109021322.1 GIY-YIG nuclease family protein -
DI077_RS16140 (LPTSP3_g31900) 3561678..3562046 - 369 WP_217351565.1 VOC family protein -
DI077_RS16145 (LPTSP3_g31910) 3562118..3562564 + 447 WP_167837187.1 MarR family transcriptional regulator -
DI077_RS16150 (LPTSP3_g31920) 3562597..3563160 + 564 WP_109021324.1 hypothetical protein -
DI077_RS16155 (LPTSP3_g31930) 3563157..3563492 + 336 WP_109021325.1 hypothetical protein -
DI077_RS16160 (LPTSP3_g31940) 3563684..3564145 + 462 WP_109021326.1 VOC family protein -
DI077_RS16165 (LPTSP3_g31950) 3564449..3565015 + 567 WP_109021327.1 dihydrofolate reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3478404..3562564 84160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15688.09 Da        Isoelectric Point: 7.1662

>T39918 WP_109021321.1 NZ_AP025028:3560307-3560711 [Leptospira kobayashii]
MSQYLLDTNICIYIINKRPEAVLKKFKKISLDNIFISSITEFELRYGVEKSQRHEQNLRILEDFLGYLNIISFDGNDSNV
AANVRTRLEKKGEVIGPYDLLIASQAISRELILVTNNEKEFKRIKEIQLENWIH

Download         Length: 405 bp

>T39918 NZ_AP025028:3560307-3560711 [Leptospira kobayashii]
ATGAGCCAATATTTATTAGATACGAATATCTGTATCTATATCATTAATAAAAGGCCAGAAGCTGTTCTCAAAAAATTCAA
GAAAATCAGTTTAGATAATATCTTTATTTCCTCCATTACTGAATTCGAATTACGATATGGAGTCGAAAAGAGTCAAAGAC
ATGAACAGAATTTAAGGATACTCGAAGATTTTCTTGGGTATCTTAATATCATTTCTTTTGACGGAAATGATAGCAATGTA
GCTGCTAATGTTCGAACTAGGCTTGAAAAGAAAGGCGAAGTCATTGGACCATATGACTTATTAATTGCCTCTCAAGCTAT
TTCAAGAGAACTCATTCTTGTTACTAATAATGAAAAGGAATTCAAAAGAATTAAAGAAATCCAATTAGAGAATTGGATTC
ATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8834.08 Da        Isoelectric Point: 10.1998

>AT39918 WP_109021320.1 NZ_AP025028:3560080-3560310 [Leptospira kobayashii]
MNRAKLFKNGDSQAIRLPKEFRFNGKEVYIRKEGANVILSPIDDAADRLWSILGQFPDDLRIERNQPKGFDKRESI

Download         Length: 231 bp

>AT39918 NZ_AP025028:3560080-3560310 [Leptospira kobayashii]
ATGAATAGAGCTAAATTATTCAAAAATGGCGATAGTCAAGCAATAAGACTGCCGAAAGAGTTCAGATTTAATGGTAAGGA
AGTCTATATCAGAAAAGAGGGAGCAAATGTTATCTTATCTCCTATTGATGATGCTGCCGATAGGCTCTGGAGCATCTTAG
GGCAATTTCCTGACGACCTACGAATTGAAAGAAATCAGCCCAAAGGCTTCGACAAACGTGAAAGCATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References