Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 80777..81369 Replicon plasmid pNUITM-VS1_1
Accession NZ_AP025015
Organism Shewanella xiamenensis strain NUITM-VS1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LDO18_RS23100 Protein ID WP_115407250.1
Coordinates 80777..81031 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LDO18_RS23105 Protein ID WP_219640050.1
Coordinates 81028..81369 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO18_RS23075 (NUITMVS1_45310) 77356..78504 + 1149 WP_224022217.1 DGQHR domain-containing protein -
LDO18_RS23080 (NUITMVS1_45320) 78501..78803 + 303 WP_224022218.1 hypothetical protein -
LDO18_RS23085 (NUITMVS1_45330) 78940..79176 + 237 WP_224022219.1 hypothetical protein -
LDO18_RS23090 (NUITMVS1_45340) 79220..79567 + 348 WP_224022220.1 hypothetical protein -
LDO18_RS23095 (NUITMVS1_45350) 80051..80692 + 642 WP_224022221.1 site-specific integrase -
LDO18_RS23100 (NUITMVS1_45360) 80777..81031 + 255 WP_115407250.1 type II toxin-antitoxin system HicA family toxin Toxin
LDO18_RS23105 (NUITMVS1_45370) 81028..81369 + 342 WP_219640050.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LDO18_RS23110 (NUITMVS1_45380) 81384..81668 + 285 WP_140907763.1 hypothetical protein -
LDO18_RS23115 (NUITMVS1_45390) 81684..81902 + 219 WP_140907762.1 hypothetical protein -
LDO18_RS23120 (NUITMVS1_45400) 81929..82351 + 423 WP_224022222.1 hypothetical protein -
LDO18_RS23125 (NUITMVS1_45410) 82413..82670 + 258 WP_224022223.1 hypothetical protein -
LDO18_RS23130 (NUITMVS1_45430) 83120..83284 + 165 WP_224022224.1 hypothetical protein -
LDO18_RS23135 (NUITMVS1_45440) 83301..83711 + 411 WP_224022225.1 hypothetical protein -
LDO18_RS23140 (NUITMVS1_45450) 83724..83918 + 195 WP_224022226.1 hypothetical protein -
LDO18_RS23145 (NUITMVS1_45460) 83941..84159 + 219 WP_224022227.1 hypothetical protein -
LDO18_RS23150 (NUITMVS1_45480) 84409..84597 + 189 WP_088212943.1 hypothetical protein -
LDO18_RS23155 (NUITMVS1_45490) 84620..84820 + 201 WP_088212942.1 hypothetical protein -
LDO18_RS23160 (NUITMVS1_45510) 85188..85400 + 213 WP_224022228.1 hypothetical protein -
LDO18_RS23165 (NUITMVS1_45520) 85534..85773 + 240 WP_224022229.1 hypothetical protein -
LDO18_RS23170 (NUITMVS1_45530) 85845..86309 + 465 WP_224022230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..131441 131441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-74)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9380.88 Da        Isoelectric Point: 10.4023

>T39915 WP_115407250.1 NZ_AP025015:80777-81031 [Shewanella xiamenensis]
MNKKHLRTLAAIFARPVSGSIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKGAVVSVKKWLERN
GVKA

Download         Length: 255 bp

>T39915 NZ_AP025015:80777-81031 [Shewanella xiamenensis]
ATGAACAAGAAACATTTAAGAACATTAGCGGCCATTTTTGCTAGACCAGTTAGCGGTTCTATCAAGTGGTCTGATATTGA
AGCGTTGTTTATTGCTCTAGGGGCAGACATAGAAGAACGTGAGGGGTCTCGAATTGGTGTGGTGCTGTTTGGTGAAGTTC
AGGTATATCACCGCCCACACCCACAGAAAGAAACCGACAAGGGCGCAGTGGTAAGCGTCAAGAAATGGCTAGAAAGAAAC
GGGGTAAAAGCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12478.05 Da        Isoelectric Point: 4.5431

>AT39915 WP_219640050.1 NZ_AP025015:81028-81369 [Shewanella xiamenensis]
MKNLMMINGVKAVIDYDAEAETFRGEFVGLNGGADFYGESISQLETEGAKSLKVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIQHSA

Download         Length: 342 bp

>AT39915 NZ_AP025015:81028-81369 [Shewanella xiamenensis]
ATGAAAAATCTAATGATGATTAACGGGGTAAAAGCCGTTATTGATTATGACGCTGAGGCTGAAACATTCCGTGGTGAGTT
CGTTGGCTTAAACGGCGGCGCGGATTTCTACGGTGAAAGCATTTCTCAATTAGAAACTGAGGGCGCGAAGTCGCTAAAGG
TCTTTTTAGAGATGTGTCAGGAGCGCGGCATTGAGCCTTATAAAAACTTCTCTGGCAAATTCAATGTGCGGATCTCGCCA
GAAGTTCACGCTCGACTTAACGAAATCGCGCTATCGCAAAGCATTAGTTTAAATGCAGCGGTAGAAAACGCGGTCAATGA
TTACATTCAACACTCAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References