Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4305090..4306631 Replicon chromosome
Accession NZ_AP025014
Organism Shewanella xiamenensis strain NUITM-VS1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LDO18_RS19115 Protein ID WP_224021108.1
Coordinates 4305090..4306391 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LDO18_RS19120 Protein ID WP_047539109.1
Coordinates 4306395..4306631 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO18_RS19085 (NUITMVS1_37310) 4300549..4300884 - 336 WP_224021105.1 c-type cytochrome -
LDO18_RS19090 (NUITMVS1_37320) 4300881..4301264 - 384 WP_133179633.1 cytochrome C -
LDO18_RS19095 (NUITMVS1_37330) 4301264..4302490 - 1227 WP_224021106.1 sulfite oxidase -
LDO18_RS19100 (NUITMVS1_37340) 4302492..4302794 - 303 WP_140907371.1 cytochrome C -
LDO18_RS19105 (NUITMVS1_37350) 4303083..4303784 - 702 WP_224021107.1 DUF4276 family protein -
LDO18_RS19110 (NUITMVS1_37360) 4303745..4304848 - 1104 WP_169548580.1 AAA family ATPase -
LDO18_RS19115 (NUITMVS1_37370) 4305090..4306391 - 1302 WP_224021108.1 type II toxin-antitoxin system toxin serine/threonine-protein kinase HipA Toxin
LDO18_RS19120 (NUITMVS1_37380) 4306395..4306631 - 237 WP_047539109.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LDO18_RS19125 (NUITMVS1_37390) 4307067..4308704 - 1638 WP_037430013.1 chaperonin GroEL -
LDO18_RS19130 (NUITMVS1_37400) 4308763..4309053 - 291 WP_011071021.1 co-chaperone GroES -
LDO18_RS19135 (NUITMVS1_37410) 4309281..4310639 + 1359 WP_037414232.1 MATE family efflux transporter -
LDO18_RS19140 (NUITMVS1_37420) 4310636..4311625 - 990 WP_109277898.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48784.16 Da        Isoelectric Point: 5.4888

>T39913 WP_224021108.1 NZ_AP025014:c4306391-4305090 [Shewanella xiamenensis]
MSTAKTLTLEMHLGDLMIGELSFDATTDTFAVYYTKDWQQSGFPLSPTIPLDCTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAIAFVPKGALLPETQLRPIKAAEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GKEFAFAEGTLSSTHIVKFEKYHHLVINEFITMRLAKVIGMNVANVDIVHFGSYKALCVERFDRRYIPSEQRVLRRHIVD
SCQALGFSVSKKYERNFGTGRDVKDIREGVSFKRLFSLAEKCRNPVAAKQDILQWTLFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFMDGLGLPRNLLVSNLTRIARRIPQAIAEVILMLPPLD
EDEASFVAHYKAQLLARCERYLSFADEVRDVEV

Download         Length: 1302 bp

>T39913 NZ_AP025014:c4306391-4305090 [Shewanella xiamenensis]
ATGAGTACAGCTAAAACGCTTACGCTAGAGATGCACCTCGGTGATTTAATGATCGGGGAATTATCCTTTGATGCCACGAC
CGACACCTTTGCGGTGTATTACACCAAAGATTGGCAGCAAAGTGGGTTTCCACTATCCCCAACGATTCCTTTAGATTGCA
CAGGAACGAGCAATCAAATATCAATGTTTTTGGTCAACTTATTACCAGAAAACAAAGGATTAGATTATCTGATTGAATCG
CTTGGCGTCTCTAAGGGGAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACCGCAGGTGCCATCGCTTTCGTTCC
TAAAGGGGCTTTACTGCCTGAAACACAATTGCGGCCAATTAAGGCTGCAGAAGTTATTCAACGCATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTATCGGTAGCGGGTGTTCAACCTAAATTAAACCTGTTTTATAAC
GGGAAAGAATTTGCCTTTGCCGAAGGTACGCTGTCATCGACCCACATAGTTAAATTCGAAAAATATCATCATTTAGTGAT
CAATGAATTTATAACGATGCGTTTGGCCAAAGTGATTGGAATGAATGTGGCGAATGTCGATATTGTTCATTTTGGCAGTT
ACAAAGCCCTTTGTGTTGAACGCTTTGACAGACGTTATATACCAAGCGAGCAAAGGGTGTTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTAAGCAAAAAATATGAACGTAATTTCGGTACGGGGCGCGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAAGAGGCTATTTAGTCTTGCTGAAAAATGCCGTAATCCCGTGGCTGCTAAGCAAGACATATTGC
AATGGACGCTATTCAATTTACTGACCGGTAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACGCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATTGA
TGACGAATTTGATCCAAATAGCATTTACGCCTATCAATTAGCCGCGTTTATGGATGGCTTGGGTTTACCAAGAAATTTAT
TAGTCAGTAACTTAACGAGAATAGCGCGGAGAATACCGCAGGCAATAGCGGAGGTGATTTTAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCTCATTACAAAGCGCAGTTACTGGCGAGATGTGAACGTTACCTTAGTTTTGCTGACGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8500.83 Da        Isoelectric Point: 7.9727

>AT39913 WP_047539109.1 NZ_AP025014:c4306631-4306395 [Shewanella xiamenensis]
MASPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSAQTSNTETNGWY

Download         Length: 237 bp

>AT39913 NZ_AP025014:c4306631-4306395 [Shewanella xiamenensis]
ATGGCATCACCGCTAAATCAGCAATCCCTCGGCTTGTTAATTAAAGAACGCAGGAAAAGTGCTGCTCTTACCCAAGACGT
GGCGGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAGGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTTGGGATTGATATCGTTTCGGCTCAAACCAGCAATACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References