Detailed information of TA system TA039910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 2768542..2769107
• Replicon: chromosome
• Accession: NZ_AP025014
• Organism: Shewanella xiamenensis strain NUITM-VS1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LDO18_RS12370
• Protein ID: WP_172591152.1
• Coordinates: 2768814..2769107 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: A0A448EM94
• Locus tag: LDO18_RS12365
• Protein ID: WP_011716807.1
• Coordinates: 2768542..2768826 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO18_RS12325 (NUITMVS1_23940)	2763792..2764298	+	507	WP_224020620.1	DNA repair protein RadC	-
LDO18_RS12330 (NUITMVS1_23950)	2764339..2764701	+	363	WP_224020621.1	hypothetical protein	-
LDO18_RS12335 (NUITMVS1_23960)	2764831..2765187	+	357	WP_224020622.1	type IV toxin-antitoxin system YeeU family antitoxin	-
LDO18_RS12340 (NUITMVS1_23970)	2765431..2765844	+	414	WP_224020623.1	DUF2787 domain-containing protein	-
LDO18_RS12345	2765960..2766263	+	304	Protein_2368	site-specific integrase	-
LDO18_RS12350 (NUITMVS1_23980)	2766365..2766772	+	408	WP_224020624.1	DUF2787 domain-containing protein	-
LDO18_RS12355 (NUITMVS1_23990)	2766881..2767447	+	567	WP_028760122.1	site-specific integrase	-
LDO18_RS12360 (NUITMVS1_24000)	2767536..2768258	+	723	WP_224020625.1	lecithin retinol acyltransferase family protein	-
LDO18_RS12365 (NUITMVS1_24010)	2768542..2768826	+	285	WP_011716807.1	CopG family ribbon-helix-helix protein	Antitoxin
LDO18_RS12370 (NUITMVS1_24020)	2768814..2769107	+	294	WP_172591152.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDO18_RS12375 (NUITMVS1_24030)	2769257..2769934	-	678	WP_224020626.1	inovirus Gp2 family protein	-
LDO18_RS12380 (NUITMVS1_24040)	2770249..2771718	-	1470	WP_224020627.1	YfjI family protein	-
LDO18_RS12385	2771756..2771968	-	213	WP_080612395.1	AlpA family phage regulatory protein	-
LDO18_RS12390 (NUITMVS1_24050)	2772087..2773172	-	1086	WP_224020628.1	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2758537..2774317	15780

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11067.62 Da
• Isoelectric Point: 6.9772

>T39910 WP_172591152.1 NZ_AP025014:2768814-2769107 [Shewanella xiamenensis]
MPQIVFTATALRDLERLREFLRSKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGGTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Nucleotide

• Length: 294 bp

>T39910 NZ_AP025014:2768814-2769107 [Shewanella xiamenensis]
ATGCCACAAATAGTCTTCACTGCCACTGCATTACGTGATTTAGAACGCTTACGTGAGTTTCTTCGCAGTAAAAATCCCCC
TGCCGCACAACGGGCTGCCAGCGCCATAATCAATACCATTAGAAAACTGGAAAGCTATCCAGACATTGGTCGGCCTATCG
ATGACAATGACTTTAGCTTTAGGGAACTGCTCATTGACTTTGGTGGTACAGGCTATCTGGCAATGTACCAGTATGATGGC
GGCGAACGATTGACCGTATTGTGTATCCGCCACCAAAAAGAAGCCGGATATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10955.25 Da
• Isoelectric Point: 5.9920

>AT39910 WP_011716807.1 NZ_AP025014:2768542-2768826 [Shewanella xiamenensis]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEQAAPTCHK

Nucleotide

• Length: 285 bp

>AT39910 NZ_AP025014:2768542-2768826 [Shewanella xiamenensis]
ATGAGCACAATCAAACCCGTGTCGGTTAAATTAGATGCCGATATTAAAGCAAGAGTCGAGCATTTAGCAGAAACCCGTAA
ACGTTCATCACACTGGATGATGCGTGAAGCGATCCGTGAATACGTTGAGAGAGAAGAGAAACGCGAAGCTTTGCAGCAAG
AAGCGTTACGCGCATGGGAAGAACACCAGACATCAGGCTTGCATGTCACCGGTGACGAAGTGGTGAGTTGGCTGGAGTCC
TGGGGAAGTGAAAATGAACAGGCTGCCCCTACATGCCACAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A448EM94