Detailed information of TA system TA039909

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 1646360..1647176
• Replicon: chromosome
• Accession: NZ_AP025014
• Organism: Shewanella xiamenensis strain NUITM-VS1

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: LDO18_RS07430
• Protein ID: WP_224021888.1
• Coordinates: 1646360..1646761 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: A0A501X4H4
• Locus tag: LDO18_RS07435
• Protein ID: WP_069455294.1
• Coordinates: 1646754..1647176 (-)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO18_RS07420	1644287..1644628	+	342	Protein_1428	transposase	-
LDO18_RS07425 (NUITMVS1_14460)	1645135..1646166	+	1032	WP_088585343.1	dTDP-glucose 4,6-dehydratase	-
LDO18_RS07430 (NUITMVS1_14470)	1646360..1646761	-	402	WP_224021888.1	type II toxin-antitoxin system toxin	Toxin
LDO18_RS07435 (NUITMVS1_14480)	1646754..1647176	-	423	WP_069455294.1	type II toxin-antitoxin system antitoxin	Antitoxin
LDO18_RS07440 (NUITMVS1_14490)	1647283..1648050	-	768	WP_224021889.1	HutD family protein	-
LDO18_RS07445 (NUITMVS1_14500)	1648326..1648772	-	447	WP_224022139.1	copper resistance protein NlpE	-
LDO18_RS07450 (NUITMVS1_14510)	1649163..1650524	+	1362	WP_224021890.1	GAF domain-containing sensor histidine kinase	-
LDO18_RS07455 (NUITMVS1_14520)	1650668..1651558	+	891	WP_055646646.1	glucose-1-phosphate thymidylyltransferase RfbA	-
LDO18_RS07460 (NUITMVS1_14530)	1651545..1652087	+	543	WP_037428279.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1644338..1644535	197

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (12-129)

Antitoxin

• Polymerase beta, nucleotidyltransferase (7-97)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15324.62 Da
• Isoelectric Point: 6.3185

>T39909 WP_224021888.1 NZ_AP025014:c1646761-1646360 [Shewanella xiamenensis]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIVVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Nucleotide

• Length: 402 bp

>T39909 NZ_AP025014:c1646761-1646360 [Shewanella xiamenensis]
TTGAATGACATTATTATCAATAAAATAGCCACCATCAAACGCTGTATAAAGCGCATCCAACAAGTCTATGGTGATGGAAG
CCAGTTCAAACAAGACTTCACCTTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCTGTATCGACATAG
CCAATCATATTAACCGCCAACAACAACTAGGCATCCCCCAAAGTAGCCGTGATAGCTTTACATTACTCGCACAAAATAAC
CTTATTACTCAGCCACTCGCAGATAACTTAAAGAAAATGGTCGGCCTGCGAAACATCGTAGTACATGACTACCAAGAACT
CAACCTTGATATCGTTGTCCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGATGTGATAAAAGCAGAGT
GA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 15795.88 Da
• Isoelectric Point: 5.1520

>AT39909 WP_069455294.1 NZ_AP025014:c1647176-1646754 [Shewanella xiamenensis]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE

Nucleotide

• Length: 423 bp

>AT39909 NZ_AP025014:c1647176-1646754 [Shewanella xiamenensis]
ATGCAACAACTAAATGAAAAGAAAATCATAAAGTTACTGCGAGACAACATCCCAAAGTTGCAATTAATCTACCTGTTTGG
CTCTTATTCGCAGGGAACACAACACCGCAACAGCGATATCGATATCGCGGTACTCGCCGCTGACACTTTAGACAATATTG
CACGCTGGGAACTTGCCCAAAAACTCGCTTCGGCGTTGGACTCAGATGTTGATCTGGTTGATTTACGCTCAGCATCCACA
GTGTTATGCCAACAGGTAGTCACTCAAGGGAAGCAACTTTGGGGAACACAACAAGATGATGAACTTTTTGCCGTAAAGAC
CATCTCAATGTACCAACATCTACAAGCCGAAAGACAGGCAATTATTGATGATGTAATGGCCAACACCGCAGCCAAAGATC
ATAGGGGGAGTCACTTTGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A501X4H4