Detailed information of TA system TA039908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1599964..1600556
• Replicon: chromosome
• Accession: NZ_AP025014
• Organism: Shewanella xiamenensis strain NUITM-VS1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A252ENI2
• Locus tag: LDO18_RS07250
• Protein ID: WP_014610888.1
• Coordinates: 1600302..1600556 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LDO18_RS07245
• Protein ID: WP_014610889.1
• Coordinates: 1599964..1600305 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO18_RS07220	1595111..1595746	+	636	Protein_1389	IS66 family transposase	-
LDO18_RS07225 (NUITMVS1_14070)	1595659..1597272	+	1614	WP_037431746.1	IS1634 family transposase	-
LDO18_RS07230 (NUITMVS1_14080)	1597402..1597701	+	300	Protein_1391	CcdB family protein	-
LDO18_RS07235 (NUITMVS1_14090)	1598056..1599423	+	1368	WP_088212883.1	HipA domain-containing protein	-
LDO18_RS07240 (NUITMVS1_14100)	1599420..1599800	+	381	WP_086904820.1	helix-turn-helix transcriptional regulator	-
LDO18_RS07245 (NUITMVS1_14110)	1599964..1600305	-	342	WP_014610889.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LDO18_RS07250 (NUITMVS1_14120)	1600302..1600556	-	255	WP_014610888.1	type II toxin-antitoxin system HicA family toxin	Toxin
LDO18_RS07255 (NUITMVS1_14140)	1600912..1601463	+	552	Protein_1396	GDP-mannose 4,6-dehydratase	-
LDO18_RS07260	1601535..1601711	+	177	WP_197721152.1	tyrosine-type recombinase/integrase	-
LDO18_RS07265 (NUITMVS1_14150)	1601789..1601953	-	165	WP_014610884.1	hypothetical protein	-
LDO18_RS07270 (NUITMVS1_14160)	1601975..1602700	-	726	WP_224021883.1	zeta toxin family protein	-
LDO18_RS07275 (NUITMVS1_14170)	1602774..1603940	-	1167	WP_224021884.1	DUF3596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1595659..1597272	1613

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9480.99 Da
• Isoelectric Point: 10.1453

>T39908 WP_014610888.1 NZ_AP025014:c1600556-1600302 [Shewanella xiamenensis]
MNKKHLRTLTAIFARPVSGAIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVISIKKWLERN
GVKA

Nucleotide

• Length: 255 bp

>T39908 NZ_AP025014:c1600556-1600302 [Shewanella xiamenensis]
ATGAACAAAAAACATTTAAGAACGTTGACGGCTATCTTTGCTAGGCCTGTCAGCGGAGCTATCAAGTGGTCTGATATTGA
AGCGCTGTTTATTGCTCTAGGGGCTGACATTGAAGAGCGTGAGGGGTCTCGAATTGGTGTGGTGCTGTTTGGTGAAGTTC
AGGTATATCACCGCCCACATCCTCAGAAAGAAACTGACAAAGACGCAGTGATAAGCATCAAAAAATGGTTAGAAAGGAAC
GGGGTGAAAGCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12409.94 Da
• Isoelectric Point: 4.3992

>AT39908 WP_014610889.1 NZ_AP025014:c1600305-1599964 [Shewanella xiamenensis]
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGTKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA

Nucleotide

• Length: 342 bp

>AT39908 NZ_AP025014:c1600305-1599964 [Shewanella xiamenensis]
ATGAAAAATCTTATGATGATCAACGGGGTAAAAGCCTTTATTGATTATGATCCAGACGCTGAAACATTCCGTGGTGAGTT
CGTAGGCTTAAACGGCGGCGCGGATTTCTATGGTGAAAGCGTCGCTCAATTGGAAGCCGAGGGCACGAAGTCATTAAGCG
TTTTTTTAGAGATGTGTCAGGAGCGTGGCATTGAGCCTTACAAAAACTTCTCTGGCAAATTCAACGTTCGGATCTCGCCA
GAGGTTCACGCTCGACTTAATGAAATTGCGCTATCGCAAAGCATTAGTTTGAATGCAGCGGTAGAAAATGCAGTCAATGA
CTACATTGCACATTCAGCGTAG

Structures

Toxin

• AlphaFold DB: A0A252ENI2