Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 58445..59088 | Replicon | plasmid pNUITM-VR1_4 |
| Accession | NZ_AP025013 | ||
| Organism | Raoultella ornithinolytica strain NUITM-VR1 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q84A06 |
| Locus tag | LDO46_RS31065 | Protein ID | WP_000754566.1 |
| Coordinates | 58445..58861 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q84A07 |
| Locus tag | LDO46_RS31070 | Protein ID | WP_001261276.1 |
| Coordinates | 58858..59088 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDO46_RS31025 (NUITMVR1_61330) | 53573..53974 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| LDO46_RS31030 (NUITMVR1_61340) | 53907..54164 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| LDO46_RS31035 (NUITMVR1_61350) | 54257..54910 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| LDO46_RS31040 (NUITMVR1_61360) | 55480..55815 | + | 336 | Protein_57 | Tn3 family transposase | - |
| LDO46_RS31045 (NUITMVR1_61370) | 55952..56449 | - | 498 | WP_032446861.1 | hypothetical protein | - |
| LDO46_RS31050 (NUITMVR1_61380) | 56458..56880 | - | 423 | WP_032446862.1 | hypothetical protein | - |
| LDO46_RS31055 (NUITMVR1_61390) | 56903..57103 | - | 201 | Protein_60 | transposase | - |
| LDO46_RS31060 | 57385..58241 | - | 857 | Protein_61 | IS3-like element ISEc15 family transposase | - |
| LDO46_RS31065 (NUITMVR1_61420) | 58445..58861 | - | 417 | WP_000754566.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LDO46_RS31070 (NUITMVR1_61430) | 58858..59088 | - | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LDO46_RS31075 (NUITMVR1_61440) | 59662..60012 | + | 351 | WP_000493378.1 | hypothetical protein | - |
| LDO46_RS31080 (NUITMVR1_61450) | 60063..60806 | + | 744 | WP_000129823.1 | hypothetical protein | - |
| LDO46_RS31085 (NUITMVR1_61460) | 60803..61578 | + | 776 | Protein_66 | site-specific integrase | - |
| LDO46_RS31090 (NUITMVR1_61470) | 61636..61893 | - | 258 | WP_000764642.1 | hypothetical protein | - |
| LDO46_RS31095 | 62022..62126 | - | 105 | WP_032409716.1 | hypothetical protein | - |
| LDO46_RS31100 (NUITMVR1_61480) | 62656..63522 | + | 867 | WP_004118283.1 | replication initiation protein | - |
| LDO46_RS31105 (NUITMVR1_61490) | 63699..63968 | - | 270 | WP_000339857.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | aph(3'')-Ib / aph(6)-Id / qnrS1 / blaNDM-1 / blaTEM-1B / rmtB / qepA1 / sul2 / tet(A) | htpB | 1..107444 | 107444 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15006.52 Da Isoelectric Point: 9.2957
>T39906 WP_000754566.1 NZ_AP025013:c58861-58445 [Raoultella ornithinolytica]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T39906 NZ_AP025013:c58861-58445 [Raoultella ornithinolytica]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT39906 WP_001261276.1 NZ_AP025013:c59088-58858 [Raoultella ornithinolytica]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT39906 NZ_AP025013:c59088-58858 [Raoultella ornithinolytica]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K1G3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K023 |