Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 3333458..3334089 | Replicon | chromosome |
| Accession | NZ_AP025009 | ||
| Organism | Raoultella ornithinolytica strain NUITM-VR1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1Q8YTV3 |
| Locus tag | LDO46_RS15670 | Protein ID | WP_012542177.1 |
| Coordinates | 3333913..3334089 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A2X1QFN9 |
| Locus tag | LDO46_RS15665 | Protein ID | WP_012542176.1 |
| Coordinates | 3333458..3333865 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDO46_RS15625 (NUITMVR1_30840) | 3330079..3330513 | - | 435 | WP_012542168.1 | phage terminase small subunit P27 family | - |
| LDO46_RS15630 (NUITMVR1_30850) | 3330763..3331194 | - | 432 | WP_081351910.1 | hypothetical protein | - |
| LDO46_RS15635 (NUITMVR1_30860) | 3331191..3331463 | - | 273 | WP_021462600.1 | hypothetical protein | - |
| LDO46_RS15640 (NUITMVR1_30870) | 3331460..3331822 | - | 363 | WP_014228901.1 | HNH endonuclease | - |
| LDO46_RS15645 (NUITMVR1_30880) | 3331806..3331967 | - | 162 | WP_023328098.1 | hypothetical protein | - |
| LDO46_RS15650 (NUITMVR1_30890) | 3332049..3332525 | - | 477 | WP_050583645.1 | DUF2514 domain-containing protein | - |
| LDO46_RS15655 (NUITMVR1_30900) | 3332558..3333088 | - | 531 | WP_023328100.1 | lysozyme | - |
| LDO46_RS15660 (NUITMVR1_30910) | 3333066..3333302 | - | 237 | WP_004111739.1 | class II holin family protein | - |
| LDO46_RS15665 (NUITMVR1_30920) | 3333458..3333865 | - | 408 | WP_012542176.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LDO46_RS15670 (NUITMVR1_30930) | 3333913..3334089 | - | 177 | WP_012542177.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LDO46_RS15675 (NUITMVR1_30940) | 3334454..3335599 | + | 1146 | WP_023328101.1 | nucleoid-associated protein | - |
| LDO46_RS15680 (NUITMVR1_30950) | 3335589..3336815 | + | 1227 | WP_023328102.1 | hypothetical protein | - |
| LDO46_RS15685 (NUITMVR1_30960) | 3336810..3337154 | - | 345 | WP_032435861.1 | antiterminator Q family protein | - |
| LDO46_RS15690 (NUITMVR1_30970) | 3337167..3338198 | - | 1032 | WP_071359307.1 | DUF968 domain-containing protein | - |
| LDO46_RS15695 (NUITMVR1_30980) | 3338398..3338790 | - | 393 | WP_025861428.1 | DNA-binding protein | - |
| LDO46_RS15700 (NUITMVR1_30990) | 3338831..3339088 | - | 258 | WP_223369409.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3301330..3358279 | 56949 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6632.83 Da Isoelectric Point: 11.0174
>T39899 WP_012542177.1 NZ_AP025009:c3334089-3333913 [Raoultella ornithinolytica]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
Download Length: 177 bp
>T39899 NZ_AP025009:c3334089-3333913 [Raoultella ornithinolytica]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AGCTCGGCATCAAATAA
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AGCTCGGCATCAAATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14977.99 Da Isoelectric Point: 4.4277
>AT39899 WP_012542176.1 NZ_AP025009:c3333865-3333458 [Raoultella ornithinolytica]
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
Download Length: 408 bp
>AT39899 NZ_AP025009:c3333865-3333458 [Raoultella ornithinolytica]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACAGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCTTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCATGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTATCTCTTGGTCACAGCACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACAGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCTTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCATGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTATCTCTTGGTCACAGCACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Q8YTV3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2X1QFN9 |