Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2742748..2744351 Replicon chromosome
Accession NZ_AP025009
Organism Raoultella ornithinolytica strain NUITM-VR1

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Y6GHD8
Locus tag LDO46_RS12925 Protein ID WP_015584335.1
Coordinates 2742748..2744079 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A808YAX5
Locus tag LDO46_RS12930 Protein ID WP_032717448.1
Coordinates 2744079..2744351 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO46_RS12910 (NUITMVR1_25430) 2738622..2739536 - 915 WP_088883967.1 branched-chain amino acid ABC transporter permease LivH -
LDO46_RS12915 (NUITMVR1_25440) 2739636..2740694 - 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
LDO46_RS12920 (NUITMVR1_25450) 2741409..2742815 + 1407 WP_015584334.1 glycoside hydrolase family 10 protein -
LDO46_RS12925 (NUITMVR1_25460) 2742748..2744079 - 1332 WP_015584335.1 type II toxin-antitoxin system HipA family toxin Toxin
LDO46_RS12930 (NUITMVR1_25470) 2744079..2744351 - 273 WP_032717448.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LDO46_RS12935 (NUITMVR1_25480) 2744555..2745109 - 555 WP_118860079.1 RNA polymerase sigma factor -
LDO46_RS12940 (NUITMVR1_25490) 2745115..2745540 - 426 WP_118860078.1 hypothetical protein -
LDO46_RS12945 (NUITMVR1_25500) 2745673..2746626 - 954 WP_004861921.1 hypothetical protein -
LDO46_RS12950 (NUITMVR1_25510) 2746840..2747472 - 633 WP_004861917.1 class I SAM-dependent methyltransferase -
LDO46_RS12955 (NUITMVR1_25520) 2747492..2748733 - 1242 WP_004861912.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49327.66 Da        Isoelectric Point: 6.7012

>T39898 WP_015584335.1 NZ_AP025009:c2744079-2742748 [Raoultella ornithinolytica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Download         Length: 1332 bp

>T39898 NZ_AP025009:c2744079-2742748 [Raoultella ornithinolytica]
ATGGCGACTCTCGTGACATGGATGAACAATGAGCGGGTCGGCGAGCTAATCAAGCAGGCGAACGGCGCACATCTCTTTCG
CTATGAAGAGGCGTGGATGCGCAATCCGCGCGCCAGACCGCTCTCACTGTCGCTTCCGCTGCAGTACGGTAACATCACCG
ACGAGGCGGTATTTAACTACTTTGACAATCTGCTGCCGGACAGTCCGCGGGTACGGGACCGCATTGTTAAGCGCTATCAG
GCGCGTTCAAAGCAGCCGTTTGATCTGCTGGCCGAGATCGGACGGGACAGCGTCGGGGCGGTAACGTTACTCCCGCCAGG
AGAAAATGCGCCCCGCGGGGCGTTGAGCTGGGAGCCGCTGGATAACCACGCTCTGGATGCGTTACTGACGGCCTACCAGT
CGGATATACCGCTCGGAATGGTCAACGAACACGATGATTTCAGGATCTCGGTGGCCGGGGCCCAGGAGAAAACCGCGCTG
CTGAAAATCGGTGAGCAGTGGTGTATCCCGACGGGTACCACACCGACTACCCACATCATTAAACTGCCTATCGGCGAGAT
CAAACAGCCGGATGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATTTGTGTCTGGCGCTGGCCCGGGCGCTGG
GTTTTGCCGTTCCGCCCGCCAGCATTATCCAGACAGCCAGTATCAGGGCGCTGGCGGTGGAGCGTTTCGACCGTCGCTGG
GCGCAGGAGAAAACGGTGCTGCTGCGTTTGCCGCAGGAAGATCTGTGTCAGGCCTTCGGCATTCCGTCATCGATTAAGTA
TGAGTCCGACGGCGGGCCGGGCATTCGGGCAATTATGGCTTTTCTGGTTGGCTCCAGCGAGGCACTCGAGGATCGCTATA
ACTTTATGAAGTTTATGGTGTTCCAGTGGCTGATTGGCGCAACCGATGGCCACGCCAAAAACTTCTCGATTTTCCTCCAG
CCGGGCGGCAGCTACCGCTTAACCCCGTTCTACGACATTATCTCCGCATTTCCGCTGCTTGGCGGAAAGGGACTGCACCT
GAGCGATCTCAAGCTGTCGATGAGTCTGAAGGCCAGTAAAGGGCGTAAAACGGAGATCCAGACGCTCTATCCGCGTCACT
TTCTCGCCACGGCTAAAGAGGTAGGGTTTGCCCAACAGCAGATGCTGGAGATTCTGCGCTATTTTGTCGATAACGTTCCC
CGCGCGGTTGAGGCGGTAAAGGGGACTTTACCGCCTGACTTTTCACAACCGGTATATGAGGCGATCACCGATCGCTTACT
GTGGGTCCATTCACGCTTGCAGAACGCAATGGCGGCGTCTCCGTCGGGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10365.71 Da        Isoelectric Point: 5.7971

>AT39898 WP_032717448.1 NZ_AP025009:c2744351-2744079 [Raoultella ornithinolytica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Download         Length: 273 bp

>AT39898 NZ_AP025009:c2744351-2744079 [Raoultella ornithinolytica]
ATGAGCCCTTCACCAACGATATACAGCCCGGTTCAGCTGGCAAACTATCTCAAGCTGGTGCGCCAGAAAAACCAGTGGAC
GCAGAGCGAGCTGGCTCAGCGTATGGGGATTAAACAGGCCACCGTCTCTAACTTTGAAAATCATCCCGAGAAAACGACGT
TAACCACGGTGTTTAAAATTTTACAGTCACTGGAACTGTCGATGGCGATTTGCGAAAAAAATGCGCCGGATACCGACGAT
AACCGTGATAACCCGCGGGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6GHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A808YAX5

References