Detailed information of TA system TA039897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2728445..2729196
• Replicon: chromosome
• Accession: NZ_AP025009
• Organism: Raoultella ornithinolytica strain NUITM-VR1

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: LDO46_RS12860
• Protein ID: WP_097357840.1
• Coordinates: 2728714..2729196 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A808Y4Y8
• Locus tag: LDO46_RS12855
• Protein ID: WP_015584326.1
• Coordinates: 2728445..2728723 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO46_RS12845 (NUITMVR1_25300)	2725173..2725721	+	549	WP_004862054.1	hypothetical protein	-
LDO46_RS12850 (NUITMVR1_25310)	2725879..2727804	-	1926	WP_099144833.1	C1 family peptidase	-
LDO46_RS12855 (NUITMVR1_25320)	2728445..2728723	+	279	WP_015584326.1	DUF1778 domain-containing protein	Antitoxin
LDO46_RS12860 (NUITMVR1_25330)	2728714..2729196	+	483	WP_097357840.1	GNAT family N-acetyltransferase	Toxin
LDO46_RS12865	2729315..2729683	-	369	Protein_2517	ISNCY family transposase	-
LDO46_RS12870 (NUITMVR1_25350)	2729867..2730499	+	633	WP_001567369.1	hypothetical protein	-
LDO46_RS12875 (NUITMVR1_25360)	2730528..2731931	-	1404	WP_001567368.1	ISNCY-like element ISKpn21 family transposase	-
LDO46_RS12880 (NUITMVR1_25370)	2732043..2733575	+	1533	WP_048757484.1	IS3-like element ISKpn38 family transposase	-
LDO46_RS12885 (NUITMVR1_25380)	2733727..2733885	-	159	WP_004861965.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-92)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17642.51 Da
• Isoelectric Point: 9.7381

>T39897 WP_097357840.1 NZ_AP025009:2728714-2729196 [Raoultella ornithinolytica]
MGMRPPEPLSTGHNIAEFCCQDQVLNEWLKKKALKNHSTGISRVFVVCAENTKRVIAYYSLSSGSVHRNTVPGAYRRNAP
EAVPVIVLGRLAVDAAWAGKGLGAALLKDAIYRTEHIAVQVGVRALLVHALNDEVREFYTRFGFEPSIINTLTLLFPIKV

Nucleotide

• Length: 483 bp

>T39897 NZ_AP025009:2728714-2729196 [Raoultella ornithinolytica]
ATGGGAATGAGACCACCGGAACCACTCAGCACTGGACACAACATAGCAGAATTTTGTTGTCAGGATCAGGTTCTTAACGA
GTGGTTGAAGAAGAAGGCGCTGAAGAACCACAGTACAGGCATTTCAAGGGTCTTTGTGGTCTGTGCCGAAAACACAAAAA
GGGTCATCGCGTATTACAGCTTGTCATCCGGGAGCGTGCACAGAAACACAGTACCGGGGGCATACCGTCGTAATGCACCT
GAAGCTGTACCGGTCATTGTTCTGGGAAGGCTTGCGGTCGATGCAGCCTGGGCAGGGAAGGGACTCGGAGCGGCACTGCT
TAAGGATGCAATATACCGTACAGAACATATCGCAGTTCAGGTCGGTGTAAGGGCGCTTCTCGTCCATGCCTTGAATGATG
AAGTCAGGGAGTTTTACACCAGGTTTGGATTCGAGCCCTCGATTATCAATACACTGACATTATTGTTCCCGATAAAAGTA
TGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10714.30 Da
• Isoelectric Point: 4.6722

>AT39897 WP_015584326.1 NZ_AP025009:2728445-2728723 [Raoultella ornithinolytica]
MKPDVREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDKQFASFMEELDAPMTAERQAR
IDNLMNRKSPWE

Nucleotide

• Length: 279 bp

>AT39897 NZ_AP025009:2728445-2728723 [Raoultella ornithinolytica]
ATGAAACCAGACGTTCGTGAAGCTCCGATAAACATTCGGGCGAAAACATCCCAGCGCGACCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTTGAAGTGGCCTGTCGCGAAGCTCAGGACATTCTGTTGGATCAGCGCT
TGTTCCTGCTGGACGATAAGCAGTTTGCTAGTTTCATGGAAGAGCTTGACGCACCTATGACAGCGGAGCGTCAGGCACGT
ATTGATAACCTGATGAACCGCAAATCGCCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A808Y4Y8