Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 905921..906578 Replicon chromosome
Accession NZ_AP025009
Organism Raoultella ornithinolytica strain NUITM-VR1

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag LDO46_RS04315 Protein ID WP_004867355.1
Coordinates 906168..906578 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag LDO46_RS04310 Protein ID WP_004867358.1
Coordinates 905921..906187 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO46_RS04285 (NUITMVR1_08540) 901059..902492 - 1434 WP_118860340.1 6-phospho-beta-glucosidase -
LDO46_RS04290 (NUITMVR1_08550) 902612..903340 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
LDO46_RS04295 (NUITMVR1_08560) 903390..903701 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
LDO46_RS04300 (NUITMVR1_08570) 903863..904519 + 657 WP_224050115.1 hemolysin III family protein -
LDO46_RS04305 (NUITMVR1_08580) 904641..905624 - 984 WP_015585783.1 tRNA-modifying protein YgfZ -
LDO46_RS04310 (NUITMVR1_08590) 905921..906187 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
LDO46_RS04315 (NUITMVR1_08600) 906168..906578 + 411 WP_004867355.1 protein YgfX Toxin
LDO46_RS04320 (NUITMVR1_08610) 906586..907107 - 522 WP_004867353.1 flavodoxin FldB -
LDO46_RS04325 (NUITMVR1_08620) 907285..908181 + 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
LDO46_RS04330 (NUITMVR1_08630) 908204..908917 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDO46_RS04335 (NUITMVR1_08640) 908923..910656 + 1734 WP_118860341.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T39887 WP_004867355.1 NZ_AP025009:906168-906578 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T39887 NZ_AP025009:906168-906578 [Raoultella ornithinolytica]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCCTGGCGCTCACAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
TATTGTGCTGCTGATGCCCTGGCCGCTGAGCTACACGCCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGTCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGATCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT39887 WP_004867358.1 NZ_AP025009:905921-906187 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT39887 NZ_AP025009:905921-906187 [Raoultella ornithinolytica]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References