Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 351295..351860 | Replicon | chromosome |
| Accession | NZ_AP024968 | ||
| Organism | Vibrio cholerae strain V130003 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | M2Z51_RS15715 | Protein ID | WP_000869999.1 |
| Coordinates | 351573..351860 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | M2Z51_RS15710 | Protein ID | WP_032477343.1 |
| Coordinates | 351295..351576 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2Z51_RS15665 | 346641..346823 | + | 183 | WP_032477360.1 | DUF645 family protein | - |
| M2Z51_RS15670 (V130003_30520) | 347475..347795 | + | 321 | WP_000248687.1 | DUF4144 domain-containing protein | - |
| M2Z51_RS15675 (V130003_30530) | 347962..348321 | + | 360 | WP_001071517.1 | VOC family protein | - |
| M2Z51_RS15680 | 348305..348463 | + | 159 | WP_248529924.1 | DUF3265 domain-containing protein | - |
| M2Z51_RS15685 (V130003_30540) | 348460..348846 | + | 387 | WP_029628680.1 | MmcQ/YjbR family DNA-binding protein | - |
| M2Z51_RS15690 (V130003_30550) | 348988..349347 | + | 360 | WP_001900224.1 | hypothetical protein | - |
| M2Z51_RS15695 (V130003_30560) | 349497..349793 | + | 297 | WP_001069046.1 | hypothetical protein | - |
| M2Z51_RS15700 (V130003_30570) | 350479..350766 | + | 288 | WP_032477340.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M2Z51_RS15705 (V130003_30580) | 350777..351094 | + | 318 | WP_032477342.1 | HigA family addiction module antitoxin | - |
| M2Z51_RS15710 (V130003_30590) | 351295..351576 | + | 282 | WP_032477343.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| M2Z51_RS15715 (V130003_30600) | 351573..351860 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M2Z51_RS15720 (V130003_30610) | 352015..352512 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| M2Z51_RS15725 (V130003_30620) | 352509..352781 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| M2Z51_RS15730 | 353170..353310 | + | 141 | WP_001952202.1 | DUF645 family protein | - |
| M2Z51_RS15735 (V130003_30630) | 353557..353895 | + | 339 | WP_050503336.1 | hypothetical protein | - |
| M2Z51_RS15740 (V130003_30640) | 354062..354598 | + | 537 | WP_000469478.1 | GNAT family protein | - |
| M2Z51_RS15745 (V130003_30650) | 354769..355131 | + | 363 | WP_000391481.1 | DUF6232 family protein | - |
| M2Z51_RS15750 (V130003_30660) | 355318..355554 | - | 237 | WP_000772125.1 | RNA-binding protein | - |
| M2Z51_RS15755 (V130003_30670) | 355790..356095 | + | 306 | WP_000064427.1 | hypothetical protein | - |
| M2Z51_RS15760 | 356152..356267 | + | 116 | Protein_350 | acetyltransferase | - |
| M2Z51_RS15765 | 356436..356541 | + | 106 | Protein_351 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 304895..371259 | 66364 | |
| - | inside | Integron | - | - | 305566..368714 | 63148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T39879 WP_000869999.1 NZ_AP024968:351573-351860 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T39879 NZ_AP024968:351573-351860 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10351.89 Da Isoelectric Point: 5.1548
>AT39879 WP_032477343.1 NZ_AP024968:351295-351576 [Vibrio cholerae]
MSRIHLDQDIQSLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQSLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT39879 NZ_AP024968:351295-351576 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGTCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGTATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGTCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGTATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|