39877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 342952..343511 Replicon chromosome
Accession NZ_AP024968
Organism Vibrio cholerae strain V130003

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0N9E9
Locus tag M2Z51_RS15615 Protein ID WP_000578475.1
Coordinates 342952..343230 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag M2Z51_RS15620 Protein ID WP_000381183.1
Coordinates 343227..343511 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2Z51_RS15570 (V130003_30430) 338191..338646 + 456 Protein_312 GNAT family N-acetyltransferase -
M2Z51_RS15575 (V130003_30440) 338793..339152 + 360 WP_000609948.1 HNH endonuclease signature motif containing protein -
M2Z51_RS15580 (V130003_30450) 339320..339598 - 279 WP_000578473.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
M2Z51_RS15585 (V130003_30460) 339595..339879 - 285 WP_000381186.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
M2Z51_RS15590 340491..340697 + 207 WP_080284769.1 DUF3709 domain-containing protein -
M2Z51_RS15595 (V130003_30470) 341014..341406 + 393 WP_001085003.1 nuclear transport factor 2 family protein -
M2Z51_RS15600 (V130003_30480) 341546..341833 + 288 WP_032477325.1 hypothetical protein -
M2Z51_RS15605 342336..342404 + 69 Protein_319 acetyltransferase -
M2Z51_RS15610 342583..342753 + 171 WP_080284771.1 DUF645 family protein -
M2Z51_RS15615 (V130003_30500) 342952..343230 - 279 WP_000578475.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
M2Z51_RS15620 (V130003_30510) 343227..343511 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M2Z51_RS15625 343627..343770 + 144 WP_080284772.1 acetyltransferase -
M2Z51_RS15630 343870..344046 + 177 WP_001891218.1 DUF645 family protein -
M2Z51_RS15635 344427..344580 + 154 Protein_325 DUF645 family protein -
M2Z51_RS15640 345092..345218 + 127 Protein_326 DUF3265 domain-containing protein -
M2Z51_RS15645 345324..345383 + 60 WP_229022487.1 hypothetical protein -
M2Z51_RS15650 345371..345613 + 243 WP_232060211.1 DUF3709 domain-containing protein -
M2Z51_RS15655 345805..345996 + 192 WP_113707167.1 disulfide bond formation protein DsbD -
M2Z51_RS15660 346014..346250 + 237 WP_032477346.1 DUF3709 domain-containing protein -
M2Z51_RS15665 346641..346823 + 183 WP_032477360.1 DUF645 family protein -
M2Z51_RS15670 (V130003_30520) 347475..347795 + 321 WP_000248687.1 DUF4144 domain-containing protein -
M2Z51_RS15675 (V130003_30530) 347962..348321 + 360 WP_001071517.1 VOC family protein -
M2Z51_RS15680 348305..348463 + 159 WP_248529924.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrVC4 - 304895..371259 66364
- inside Integron - - 305566..368714 63148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10824.53 Da        Isoelectric Point: 4.6794

>T39877 WP_000578475.1 NZ_AP024968:c343230-342952 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T39877 NZ_AP024968:c343230-342952 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGGTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATCGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT39877 WP_000381183.1 NZ_AP024968:c343511-343227 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT39877 NZ_AP024968:c343511-343227 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0N9E9

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References