Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 339320..339879 | Replicon | chromosome |
| Accession | NZ_AP024968 | ||
| Organism | Vibrio cholerae strain V130003 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2YI11 |
| Locus tag | M2Z51_RS15580 | Protein ID | WP_000578473.1 |
| Coordinates | 339320..339598 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | M2Z51_RS15585 | Protein ID | WP_000381186.1 |
| Coordinates | 339595..339879 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2Z51_RS15530 (V130003_30380) | 335157..335894 | + | 738 | WP_032477355.1 | SDR family oxidoreductase | - |
| M2Z51_RS15535 | 335872..336009 | + | 138 | WP_113707170.1 | DUF3265 domain-containing protein | - |
| M2Z51_RS15540 | 336221..336374 | + | 154 | Protein_306 | DUF645 family protein | - |
| M2Z51_RS15545 (V130003_30390) | 336572..336892 | + | 321 | WP_000248687.1 | DUF4144 domain-containing protein | - |
| M2Z51_RS15550 (V130003_30400) | 337119..337313 | + | 195 | WP_000526238.1 | hypothetical protein | - |
| M2Z51_RS15555 | 337346..337441 | + | 96 | WP_075042587.1 | DUF3265 domain-containing protein | - |
| M2Z51_RS15560 (V130003_30410) | 337449..337766 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| M2Z51_RS15565 (V130003_30420) | 337766..338011 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| M2Z51_RS15570 (V130003_30430) | 338191..338646 | + | 456 | Protein_312 | GNAT family N-acetyltransferase | - |
| M2Z51_RS15575 (V130003_30440) | 338793..339152 | + | 360 | WP_000609948.1 | HNH endonuclease signature motif containing protein | - |
| M2Z51_RS15580 (V130003_30450) | 339320..339598 | - | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| M2Z51_RS15585 (V130003_30460) | 339595..339879 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| M2Z51_RS15590 | 340491..340697 | + | 207 | WP_080284769.1 | DUF3709 domain-containing protein | - |
| M2Z51_RS15595 (V130003_30470) | 341014..341406 | + | 393 | WP_001085003.1 | nuclear transport factor 2 family protein | - |
| M2Z51_RS15600 (V130003_30480) | 341546..341833 | + | 288 | WP_032477325.1 | hypothetical protein | - |
| M2Z51_RS15605 | 342336..342404 | + | 69 | Protein_319 | acetyltransferase | - |
| M2Z51_RS15610 | 342583..342753 | + | 171 | WP_080284771.1 | DUF645 family protein | - |
| M2Z51_RS15615 (V130003_30500) | 342952..343230 | - | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| M2Z51_RS15620 (V130003_30510) | 343227..343511 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| M2Z51_RS15625 | 343627..343770 | + | 144 | WP_080284772.1 | acetyltransferase | - |
| M2Z51_RS15630 | 343870..344046 | + | 177 | WP_001891218.1 | DUF645 family protein | - |
| M2Z51_RS15635 | 344427..344580 | + | 154 | Protein_325 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 304895..371259 | 66364 | |
| - | inside | Integron | - | - | 305566..368714 | 63148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10868.59 Da Isoelectric Point: 4.6794
>T39876 WP_000578473.1 NZ_AP024968:c339598-339320 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T39876 NZ_AP024968:c339598-339320 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
AGAAAAAACGGATGAGCTCATAGAAACCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGGGTTCAGCGTGATGGTA
TTCGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
AGAAAAAACGGATGAGCTCATAGAAACCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGGGTTCAGCGTGATGGTA
TTCGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10915.28 Da Isoelectric Point: 8.0775
>AT39876 WP_000381186.1 NZ_AP024968:c339879-339595 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT39876 NZ_AP024968:c339879-339595 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGGAC
TCTTAGCGATGCTTGCCGTGAACTCACCGAACAATTAGCTGAACAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTATTCGTTGAACATGACATCGCCAAAGTGCGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGTCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGGAC
TCTTAGCGATGCTTGCCGTGAACTCACCGAACAATTAGCTGAACAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCGGTATTCGTTGAACATGACATCGCCAAAGTGCGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGTCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|