Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 327831..328341 | Replicon | chromosome |
| Accession | NZ_AP024968 | ||
| Organism | Vibrio cholerae strain V130003 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | A0A7Z7VK37 |
| Locus tag | M2Z51_RS15470 | Protein ID | WP_000098715.1 |
| Coordinates | 328078..328341 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A7Y3QZ95 |
| Locus tag | M2Z51_RS15465 | Protein ID | WP_001223794.1 |
| Coordinates | 327831..328085 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2Z51_RS15420 (V130003_30180) | 323111..323614 | + | 504 | WP_032477327.1 | DinB family protein | - |
| M2Z51_RS15425 (V130003_30190) | 323798..324028 | - | 231 | WP_000838533.1 | PAS factor family protein | - |
| M2Z51_RS15430 (V130003_30210) | 324256..324795 | + | 540 | WP_000884557.1 | hydrolase | - |
| M2Z51_RS15435 | 325105..325287 | + | 183 | WP_000923320.1 | DUF645 family protein | - |
| M2Z51_RS15440 (V130003_30220) | 325486..325800 | + | 315 | WP_000248689.1 | DUF4144 domain-containing protein | - |
| M2Z51_RS15445 | 326145..326291 | + | 147 | WP_228006404.1 | DUF645 family protein | - |
| M2Z51_RS15450 (V130003_30230) | 326509..326865 | + | 357 | WP_001094969.1 | DUF6404 family protein | - |
| M2Z51_RS15455 (V130003_30240) | 327009..327326 | - | 318 | WP_001180238.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M2Z51_RS15460 (V130003_30250) | 327345..327587 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M2Z51_RS15465 (V130003_30260) | 327831..328085 | + | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| M2Z51_RS15470 (V130003_30270) | 328078..328341 | + | 264 | WP_000098715.1 | Txe/YoeB family addiction module toxin | Toxin |
| M2Z51_RS15475 (V130003_30280) | 328498..328980 | + | 483 | WP_000422945.1 | GNAT family protein | - |
| M2Z51_RS15480 (V130003_30290) | 329108..329398 | - | 291 | WP_032477347.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M2Z51_RS15485 (V130003_30300) | 329388..329636 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M2Z51_RS15490 (V130003_30310) | 329835..330149 | + | 315 | WP_000248689.1 | DUF4144 domain-containing protein | - |
| M2Z51_RS15495 | 330464..330586 | + | 123 | Protein_297 | DUF645 family protein | - |
| M2Z51_RS15500 | 330567..330668 | + | 102 | WP_080284778.1 | Tfp pilus assembly protein | - |
| M2Z51_RS15505 | 330821..330994 | + | 174 | WP_172779494.1 | hypothetical protein | - |
| M2Z51_RS15510 (V130003_30320) | 331333..331923 | + | 591 | WP_000589659.1 | DUF1294 domain-containing protein | - |
| M2Z51_RS15515 (V130003_30330) | 332087..332683 | + | 597 | WP_050503364.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 304895..371259 | 66364 | |
| - | inside | Integron | - | - | 305566..368714 | 63148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10415.75 Da Isoelectric Point: 7.9816
>T39874 WP_000098715.1 NZ_AP024968:328078-328341 [Vibrio cholerae]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITI
ISCRYHY
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITI
ISCRYHY
Download Length: 264 bp
>T39874 NZ_AP024968:328078-328341 [Vibrio cholerae]
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9437.64 Da Isoelectric Point: 5.0481
>AT39874 WP_001223794.1 NZ_AP024968:327831-328085 [Vibrio cholerae]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE
Download Length: 255 bp
>AT39874 NZ_AP024968:327831-328085 [Vibrio cholerae]
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCCGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCCGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z7VK37 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y3QZ95 |