Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 313818..314383 | Replicon | chromosome |
| Accession | NZ_AP024968 | ||
| Organism | Vibrio cholerae strain V130003 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | M2Z51_RS15325 | Protein ID | WP_000869999.1 |
| Coordinates | 314096..314383 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | M2Z51_RS15320 | Protein ID | WP_032477343.1 |
| Coordinates | 313818..314099 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2Z51_RS15275 (V130003_29980) | 308956..309237 | + | 282 | WP_114732512.1 | hypothetical protein | - |
| M2Z51_RS15280 (V130003_29990) | 309441..309830 | + | 390 | WP_055052207.1 | VOC family protein | - |
| M2Z51_RS15285 (V130003_30000) | 309970..310332 | + | 363 | WP_248532149.1 | SH3 domain-containing protein | - |
| M2Z51_RS15290 | 310668..310820 | + | 153 | WP_001893908.1 | DUF645 family protein | - |
| M2Z51_RS15295 (V130003_30010) | 311213..311869 | + | 657 | WP_000361704.1 | quinolone resistance pentapeptide repeat protein QnrVC4 | - |
| M2Z51_RS15300 (V130003_30020) | 312036..312332 | + | 297 | WP_069217115.1 | Dabb family protein | - |
| M2Z51_RS15305 (V130003_30030) | 312488..312775 | + | 288 | WP_032477325.1 | hypothetical protein | - |
| M2Z51_RS15310 (V130003_30040) | 313002..313289 | + | 288 | WP_032477340.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M2Z51_RS15315 (V130003_30050) | 313300..313617 | + | 318 | WP_032477342.1 | HigA family addiction module antitoxin | - |
| M2Z51_RS15320 (V130003_30060) | 313818..314099 | + | 282 | WP_032477343.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| M2Z51_RS15325 (V130003_30070) | 314096..314383 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M2Z51_RS15330 (V130003_30080) | 314538..315035 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| M2Z51_RS15335 (V130003_30090) | 315032..315304 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| M2Z51_RS15340 | 315659..315841 | + | 183 | WP_032477360.1 | DUF645 family protein | - |
| M2Z51_RS15345 (V130003_30100) | 316496..316882 | + | 387 | WP_029628680.1 | MmcQ/YjbR family DNA-binding protein | - |
| M2Z51_RS15350 (V130003_30110) | 317024..317383 | + | 360 | WP_001900224.1 | hypothetical protein | - |
| M2Z51_RS15355 (V130003_30120) | 317533..317829 | + | 297 | WP_001069046.1 | hypothetical protein | - |
| M2Z51_RS15360 | 318581..318799 | + | 219 | WP_001973795.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 304895..371259 | 66364 | |
| - | inside | Integron | - | - | 305566..368714 | 63148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T39870 WP_000869999.1 NZ_AP024968:314096-314383 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T39870 NZ_AP024968:314096-314383 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10351.89 Da Isoelectric Point: 5.1548
>AT39870 WP_032477343.1 NZ_AP024968:313818-314099 [Vibrio cholerae]
MSRIHLDQDIQSLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQSLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT39870 NZ_AP024968:313818-314099 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGTCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGTATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGTCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGTATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|