Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 151510..153185 | Replicon | chromosome |
| Accession | NZ_AP024967 | ||
| Organism | Vibrio cholerae strain V130003 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | M2Z51_RS00730 | Protein ID | WP_032477282.1 |
| Coordinates | 151974..153185 (+) | Length | 404 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A0X8LPP8 |
| Locus tag | M2Z51_RS00725 | Protein ID | WP_000649312.1 |
| Coordinates | 151510..151977 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2Z51_RS00710 (V130003_01430) | 148707..149192 | + | 486 | WP_237733639.1 | hypothetical protein | - |
| M2Z51_RS00715 (V130003_01440) | 149189..150553 | + | 1365 | WP_032477283.1 | hypothetical protein | - |
| M2Z51_RS00720 (V130003_01450) | 150553..151320 | + | 768 | WP_000230362.1 | TatD family hydrolase | - |
| M2Z51_RS00725 (V130003_01460) | 151510..151977 | + | 468 | WP_000649312.1 | DUF4065 domain-containing protein | Antitoxin |
| M2Z51_RS00730 (V130003_01470) | 151974..153185 | + | 1212 | WP_032477282.1 | RelA/SpoT domain-containing protein | Toxin |
| M2Z51_RS00735 (V130003_01480) | 153429..154538 | - | 1110 | WP_032477281.1 | tRNA (uridine(54)-C5)-methyltransferase TrmA | - |
| M2Z51_RS00740 (V130003_01490) | 154936..156771 | + | 1836 | WP_032477280.1 | TonB-dependent vitamin B12 receptor | - |
| M2Z51_RS00745 (V130003_01500) | 156947..157384 | + | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
| M2Z51_RS00750 (V130003_01510) | 157569..158006 | + | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 404 a.a. Molecular weight: 45851.69 Da Isoelectric Point: 5.2762
>T39868 WP_032477282.1 NZ_AP024967:151974-153185 [Vibrio cholerae]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYTNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYTNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN
Download Length: 1212 bp
>T39868 NZ_AP024967:151974-153185 [Vibrio cholerae]
GTGAGTGATAAAGAAAAACGTGTCGTCAGTTTTCAAATTGACGACACTCCCACCGCCGAACAGGCATCAAAAAACTTCCA
AGACGACTATGAGCTGTGCTTCCAAGATTTTCTTGAAAGAACGGTTGATGAAAGTGCCGCTGAAGATTTCTCATACACCA
ATAACGGAGTTAAGAAAGCAGGGCGACGACTACGCAAGAAAGAAGGCGATCTTAAATCCGCGACTGCGACCATCCAGCAG
TTTCGTGCAGCCCATGAAAAACCACTGAATACTATCGCCTACCTTGTTGGTCGATGTTGTCGAGAGCTTGGGATAGATGT
TAAACCAGTGACACGACTGAAGCGTTTAGAAACCATAGTAGATAAGCTACAGCGTAAATCTCTTGATGGTGAAACTACGA
ATGCGACCTGTGTAACCAATATGAACGATATTGGTGGTTGTCGGGCAATTTTCCCTGATCTTGAATCGTTGGAGAAAGCA
AAAGAGCGCCTGCAAGTTACCGTAGAAAAAGTAGGTCGAATTAAGATTAAGGACATTGATGACTACATCACTAATCCTAA
ACCTAATGACTGCGGATACCGAAGTTTGCATGTTATATATCGTTATGACCATGCCAGCGGTAAAAGTTTTAATATAGAAG
CTCAGCTACGTACTCGTCTTCAGCATCTTTGGGCGACAACAGTAGAAATCGTCGATATTTTGGAAGGTACTAAGATTAAG
ACGCATTCCCATAGCCCAGATGAAGACAAAGAGAAGTTGCAGGTTCAGTGGGAAGAGCTACTTTCCATCATGAGTCAGTA
TATTGCTGACGCCGAAGGTGCTATAGAGTTAAGCAATGACAATAGGACTCAGTTTTCAAATAGACTGATTGAATTGAATC
GTGAAATCAATGCATTGAGTCGGTTGAGAAGCTTTAAAATCTTATCTGAAAAAGTTGAAGGCTGTCGTGATGGCTCAATA
GAACATGTTCTGTTAGTTATTGACGAAACTTCGTTAGAAATGATTTTTAGTGAAGAGTTTGAGAATTATACCCAAGCTAT
CTCGGTTTATAACGCAGCTGAGAAAATGACTCGTAGTCATGCGAGATTAAACACCCTTCTTATATCTACGAAAAATATGG
GGCAACTATCAGAAGCATACCCCAACTATCTAGGTGACTGTGCTTCATTCATCACTCTGCTTGAAGACGCTATGCAATCG
GGCCAGAATTAA
GTGAGTGATAAAGAAAAACGTGTCGTCAGTTTTCAAATTGACGACACTCCCACCGCCGAACAGGCATCAAAAAACTTCCA
AGACGACTATGAGCTGTGCTTCCAAGATTTTCTTGAAAGAACGGTTGATGAAAGTGCCGCTGAAGATTTCTCATACACCA
ATAACGGAGTTAAGAAAGCAGGGCGACGACTACGCAAGAAAGAAGGCGATCTTAAATCCGCGACTGCGACCATCCAGCAG
TTTCGTGCAGCCCATGAAAAACCACTGAATACTATCGCCTACCTTGTTGGTCGATGTTGTCGAGAGCTTGGGATAGATGT
TAAACCAGTGACACGACTGAAGCGTTTAGAAACCATAGTAGATAAGCTACAGCGTAAATCTCTTGATGGTGAAACTACGA
ATGCGACCTGTGTAACCAATATGAACGATATTGGTGGTTGTCGGGCAATTTTCCCTGATCTTGAATCGTTGGAGAAAGCA
AAAGAGCGCCTGCAAGTTACCGTAGAAAAAGTAGGTCGAATTAAGATTAAGGACATTGATGACTACATCACTAATCCTAA
ACCTAATGACTGCGGATACCGAAGTTTGCATGTTATATATCGTTATGACCATGCCAGCGGTAAAAGTTTTAATATAGAAG
CTCAGCTACGTACTCGTCTTCAGCATCTTTGGGCGACAACAGTAGAAATCGTCGATATTTTGGAAGGTACTAAGATTAAG
ACGCATTCCCATAGCCCAGATGAAGACAAAGAGAAGTTGCAGGTTCAGTGGGAAGAGCTACTTTCCATCATGAGTCAGTA
TATTGCTGACGCCGAAGGTGCTATAGAGTTAAGCAATGACAATAGGACTCAGTTTTCAAATAGACTGATTGAATTGAATC
GTGAAATCAATGCATTGAGTCGGTTGAGAAGCTTTAAAATCTTATCTGAAAAAGTTGAAGGCTGTCGTGATGGCTCAATA
GAACATGTTCTGTTAGTTATTGACGAAACTTCGTTAGAAATGATTTTTAGTGAAGAGTTTGAGAATTATACCCAAGCTAT
CTCGGTTTATAACGCAGCTGAGAAAATGACTCGTAGTCATGCGAGATTAAACACCCTTCTTATATCTACGAAAAATATGG
GGCAACTATCAGAAGCATACCCCAACTATCTAGGTGACTGTGCTTCATTCATCACTCTGCTTGAAGACGCTATGCAATCG
GGCCAGAATTAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17581.02 Da Isoelectric Point: 7.5659
>AT39868 WP_000649312.1 NZ_AP024967:151510-151977 [Vibrio cholerae]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL
Download Length: 468 bp
>AT39868 NZ_AP024967:151510-151977 [Vibrio cholerae]
ATGAAAGCATATCACACATACAGTGCTGTAGACGTTGCATGGAGCTTGCTTAAGCATGCGAAAGAGCAAGGTAAATGCTT
CTCCAATTTGCAGCTACAAAAACTTACCTATGTTTGCCACGGTTTATCGTTGGCACACTTCCAGCGTCCTCTTGTTGTGG
ATGACGTATTTGCTTGGAAATTTGGTCCCGTAGTCCCTTCTGTCTATTTTCGCTTTAAATCGTATGGCAGTAACGTGATC
ACCGAACAATGTGATGTGGTGTTAGATCATGAGAGTGAGTCTATTGTCAAAGATGTAGTATCACAACTGGGGCATTTAAC
AGGCCCGCAGCTTGTAGATCTGACTCACCGAGAGGGTAGTCCATGGCATCAAGTATGGGATGGCACTCATCAAAAAGTGA
TTCCCGACCATTTGATTCAAGCTCATTACACTCAGATCAAACAATCAGGGCGAACAGCTAGCCTGTGA
ATGAAAGCATATCACACATACAGTGCTGTAGACGTTGCATGGAGCTTGCTTAAGCATGCGAAAGAGCAAGGTAAATGCTT
CTCCAATTTGCAGCTACAAAAACTTACCTATGTTTGCCACGGTTTATCGTTGGCACACTTCCAGCGTCCTCTTGTTGTGG
ATGACGTATTTGCTTGGAAATTTGGTCCCGTAGTCCCTTCTGTCTATTTTCGCTTTAAATCGTATGGCAGTAACGTGATC
ACCGAACAATGTGATGTGGTGTTAGATCATGAGAGTGAGTCTATTGTCAAAGATGTAGTATCACAACTGGGGCATTTAAC
AGGCCCGCAGCTTGTAGATCTGACTCACCGAGAGGGTAGTCCATGGCATCAAGTATGGGATGGCACTCATCAAAAAGTGA
TTCCCGACCATTTGATTCAAGCTCATTACACTCAGATCAAACAATCAGGGCGAACAGCTAGCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|