Detailed information of TA system TA039860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1566665..1567874
• Replicon: chromosome
• Accession: NZ_AP024962
• Organism: Helicobacter pylori strain #3

Toxin (Protein)

• Gene name: panT
• Uniprot ID: X2ILV7
• Locus tag: LDM86_RS07560
• Protein ID: WP_025314210.1
• Coordinates: 1566665..1567447 (-)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: X2IFS3
• Locus tag: LDM86_RS07565
• Protein ID: WP_000245673.1
• Coordinates: 1567437..1567874 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDM86_RS07550 (OHP003_15030)	1564003..1565163	+	1161	WP_223889162.1	aminotransferase class V-fold PLP-dependent enzyme	-
LDM86_RS07555 (OHP003_15040)	1565251..1566438	+	1188	WP_223889163.1	transcription termination factor NusA	-
LDM86_RS07560 (OHP003_15050)	1566665..1567447	-	783	WP_025314210.1	hypothetical protein	Toxin
LDM86_RS07565 (OHP003_15060)	1567437..1567874	-	438	WP_000245673.1	Panacea domain-containing protein	Antitoxin
LDM86_RS07570 (OHP003_15070)	1568100..1568795	-	696	WP_223889164.1	hypothetical protein	-
LDM86_RS07575 (OHP003_15080)	1568883..1569728	-	846	WP_223889165.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30638.78 Da
• Isoelectric Point: 9.2968

>T39860 WP_025314210.1 NZ_AP024962:c1567447-1566665 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILFVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T39860 NZ_AP024962:c1567447-1566665 [Helicobacter pylori]
ATGGAAACTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17309.47 Da
• Isoelectric Point: 6.7306

>AT39860 WP_000245673.1 NZ_AP024962:c1567874-1567437 [Helicobacter pylori]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINYSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKREAKQANGN

Nucleotide

• Length: 438 bp

>AT39860 NZ_AP024962:c1567874-1567437 [Helicobacter pylori]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATATG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAATTGGAAACCATCAACTACTCTATAGAAAAATGCAACGAGAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAGGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACGAGAAGCAAAACAAGCAAATGGAAACTAA

Structures

Toxin

• AlphaFold DB: X2ILV7

Antitoxin

• AlphaFold DB: X2IFS3