Detailed information of TA system TA039858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3346132..3346669
• Replicon: chromosome
• Accession: NZ_AP024961
• Organism: Legionella pneumophila strain 80-045

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDN16_RS14895
• Protein ID: WP_027266055.1
• Coordinates: 3346132..3346428 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LDN16_RS14900
• Protein ID: WP_027266056.1
• Coordinates: 3346418..3346669 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDN16_RS14865 (LEG80045_29020)	3342224..3343120	-	897	WP_027266053.1	hypothetical protein	-
LDN16_RS14870 (LEG80045_29030)	3343388..3343579	+	192	WP_014327021.1	hypothetical protein	-
LDN16_RS14875	3343728..3343832	-	105	Protein_2919	lytic murein transglycosylase	-
LDN16_RS14880 (LEG80045_29040)	3344050..3344589	-	540	WP_062730332.1	tetratricopeptide repeat protein	-
LDN16_RS14885 (LEG80045_29050)	3344549..3345202	-	654	WP_027266054.1	hypothetical protein	-
LDN16_RS14890 (LEG80045_29060)	3345561..3346043	-	483	WP_014842908.1	hypothetical protein	-
LDN16_RS14895 (LEG80045_29070)	3346132..3346428	-	297	WP_027266055.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDN16_RS14900 (LEG80045_29080)	3346418..3346669	-	252	WP_027266056.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LDN16_RS14905 (LEG80045_29090)	3346833..3348038	+	1206	WP_061638482.1	ISNCY family transposase	-
LDN16_RS14910 (LEG80045_29100)	3348211..3348411	-	201	WP_027265577.1	hypothetical protein	-
LDN16_RS14915 (LEG80045_29110)	3348989..3350128	-	1140	WP_134984249.1	DUF3800 domain-containing protein	-
LDN16_RS15395	3350246..3350353	-	108	WP_229310140.1	hypothetical protein	-
LDN16_RS14925	3350459..3350790	-	332	Protein_2929	recombinase family protein	-
LDN16_RS14930	3350878..3351018	+	141	WP_154219844.1	hypothetical protein	-
LDN16_RS14935 (LEG80045_29140)	3351043..3351546	-	504	WP_027265579.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-60)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11512.36 Da
• Isoelectric Point: 10.3916

>T39858 WP_027266055.1 NZ_AP024961:c3346428-3346132 [Legionella pneumophila]
MIYELHFHPLALKEWKKLGKNLQEEFKKVLKRRLENPHVASASLRGSLKNCYKIKLRQSGYRLVYQVNDNKLIVTVIAVG
KRNKNVVYDDADNRQEDS

Nucleotide

• Length: 297 bp

>T39858 NZ_AP024961:c3346428-3346132 [Legionella pneumophila]
ATGATTTATGAGCTTCATTTTCATCCTTTAGCTTTAAAAGAATGGAAAAAGCTGGGGAAAAACCTTCAAGAAGAATTTAA
GAAAGTGTTAAAACGCCGTTTAGAAAATCCACATGTGGCTTCGGCTAGCTTAAGAGGCTCTTTAAAAAATTGCTATAAAA
TAAAATTACGTCAATCTGGTTATCGTTTGGTGTATCAAGTTAATGATAATAAATTAATTGTAACCGTCATAGCAGTCGGG
AAAAGAAACAAAAATGTTGTCTATGATGATGCAGATAACCGACAAGAAGACAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.70 Da
• Isoelectric Point: 5.0359

>AT39858 WP_027266056.1 NZ_AP024961:c3346669-3346418 [Legionella pneumophila]
MQTLFATQVASISELKKNPTKLINDAHGKPVAILNHNTAAAYLIPVETFEKLMDLIDENELHKIVEERLSAPFTSIKVNI
DDL

Nucleotide

• Length: 252 bp

>AT39858 NZ_AP024961:c3346669-3346418 [Legionella pneumophila]
ATGCAAACTTTATTTGCTACACAAGTAGCGAGCATTAGTGAATTAAAAAAGAACCCCACTAAGCTCATTAATGATGCTCA
TGGAAAACCTGTTGCTATTCTTAACCACAATACAGCGGCAGCATATTTAATTCCTGTTGAAACATTTGAAAAACTAATGG
ATTTGATTGATGAGAATGAACTACATAAAATAGTAGAAGAGCGTTTGTCAGCACCTTTTACCTCAATAAAGGTAAATATT
GATGATTTATGA