Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1444355..1446105 Replicon chromosome
Accession NZ_AP024956
Organism Paraburkholderia terrae strain KU-64

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PTKU64_RS22585 Protein ID WP_229515248.1
Coordinates 1444355..1445248 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PTKU64_RS22590 Protein ID WP_229515249.1
Coordinates 1445245..1446105 (+) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTKU64_RS22555 (PTKU64_44590) 1439721..1440794 - 1074 WP_229515245.1 porin -
PTKU64_RS22560 (PTKU64_44600) 1441236..1441553 + 318 WP_091781007.1 non-heme iron oxygenase ferredoxin subunit -
PTKU64_RS22565 (PTKU64_44610) 1441555..1441866 + 312 WP_042304475.1 hypothetical protein -
PTKU64_RS22570 (PTKU64_44620) 1441909..1442997 + 1089 WP_229515246.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
PTKU64_RS22575 (PTKU64_44630) 1442990..1443748 + 759 WP_229515247.1 SDR family oxidoreductase -
PTKU64_RS22580 (PTKU64_44640) 1443784..1444323 + 540 WP_035999007.1 cupin domain-containing protein -
PTKU64_RS22585 (PTKU64_44650) 1444355..1445248 + 894 WP_229515248.1 alpha/beta fold hydrolase Toxin
PTKU64_RS22590 (PTKU64_44660) 1445245..1446105 + 861 WP_229515249.1 IclR family transcriptional regulator Antitoxin
PTKU64_RS22595 (PTKU64_44670) 1446105..1446911 + 807 WP_229515250.1 SDR family oxidoreductase -
PTKU64_RS22600 (PTKU64_44680) 1446904..1448562 + 1659 WP_042304481.1 thiamine pyrophosphate-binding protein -
PTKU64_RS22605 (PTKU64_44690) 1448555..1449385 + 831 WP_229515251.1 aspartate dehydrogenase -
PTKU64_RS22610 (PTKU64_44700) 1449412..1450908 + 1497 WP_229515252.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-276)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31204.01 Da        Isoelectric Point: 6.2242

>T39851 WP_229515248.1 NZ_AP024956:1444355-1445248 [Paraburkholderia terrae]
MSAALPVTVDRNATLETRLSHFPAQRISIAPQRAMGYREAGAGHADALPLVLLHGIGSGAASWVQQFESLGTTRRVFAWD
APGYGESTPVASASPEANEYASALNAWIDALDIERCVLVGHSLGAIIAGSFAASHAERVAGLLLISPAAGYGAASEEVRA
SKRDSRLAMLAELGPQGLADQRSANMLSPHADDASRDWVRWNMSRIVPHGYAQATHLLANADLASDVAKINGSIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAGNEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T39851 NZ_AP024956:1444355-1445248 [Paraburkholderia terrae]
ATGTCCGCAGCCTTGCCCGTTACTGTCGATCGAAACGCCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACAGCGGAT
CTCGATTGCGCCGCAACGCGCGATGGGTTATCGCGAGGCGGGTGCCGGCCATGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGCATTGGATCGGGCGCGGCTTCGTGGGTGCAACAGTTCGAATCGCTCGGCACGACGCGCCGTGTGTTCGCGTGGGAC
GCGCCGGGCTACGGCGAATCGACGCCAGTCGCGTCGGCGTCGCCTGAAGCAAATGAATATGCGAGCGCGCTCAACGCATG
GATCGACGCGCTCGACATAGAACGTTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCTCGTTCGCAGCGT
CGCATGCGGAACGTGTTGCCGGTCTGCTGCTGATTTCGCCCGCAGCGGGTTACGGCGCGGCATCCGAAGAAGTACGCGCA
TCGAAGCGCGACAGCCGCCTCGCGATGCTCGCCGAACTCGGCCCGCAAGGACTCGCGGACCAACGTAGCGCCAACATGTT
GTCGCCGCACGCCGACGACGCATCGCGCGACTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGCACGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGACCTCGCCAGCGATGTCGCGAAGATCAACGGCAGTATCGCCGTCGCGGTCGGCGCG
GAAGACTCGATCACGCCGCCGTCGTCATGCGAGCGGATCGCACAGGCGGCGCGTACGCGTTTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTATATCGAAGCGGGCAATGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGCCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31450.87 Da        Isoelectric Point: 6.5092

>AT39851 WP_229515249.1 NZ_AP024956:1445245-1446105 [Paraburkholderia terrae]
MTPELTGTAPEAEDDRNDANYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEKALERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRSAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT39851 NZ_AP024956:1445245-1446105 [Paraburkholderia terrae]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGAACTACCGCGTGCCCGGTCTCGA
ACGTGGCTTGCGCATTCTCACGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCCGAGTTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTTTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTGGAGCGCGCGGATCGGGACCGCAAC
TATCGCCTGGGCGTCGCGGTACTGCGCCTCGGCTTCGAATATCTCAGTTCGCTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGGCTTGCGCGACGCAACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCACAAAGCCACGCGCCCGTGTTCAGCTCGGTGAAGGTGAACGTCGGCACACGGCTGCCCGCGCATGCGACCACGCAT
GGCCATGTACTGATGGGTGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGGCGCTCGAACGCTTCACGAA
ACACACGCCCGCCACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCGGTGCGCGGCTTCGCGATCAGCGAATCAT
CCTTTGAAAACGGCATTTCCGTGATCAGCGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCCGTCATCACGACGACG
ATTCCGCGTCCGCAGATCGACGCGGCGCTGCTGGATGGCGGCCTGATCGACAAGGTGCGCAGCGCGGCTGAGCAACTGTC
GCTGCGGCTGAACTATCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References