Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1210712..1211231 Replicon chromosome
Accession NZ_AP024955
Organism Paraburkholderia terrae strain KU-64

Toxin (Protein)


Gene name relE Uniprot ID A0A2I8EI77
Locus tag PTKU64_RS05400 Protein ID WP_042314621.1
Coordinates 1210941..1211231 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A244DDI0
Locus tag PTKU64_RS05395 Protein ID WP_007585570.1
Coordinates 1210712..1210954 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTKU64_RS05375 (PTKU64_10550) 1205892..1206806 - 915 WP_229513055.1 ABC transporter permease -
PTKU64_RS05380 (PTKU64_10560) 1206846..1207670 - 825 WP_229513057.1 ABC transporter permease -
PTKU64_RS05385 (PTKU64_10570) 1207667..1208680 - 1014 WP_229513427.1 ABC transporter substrate-binding protein -
PTKU64_RS05390 (PTKU64_10580) 1208757..1209830 - 1074 WP_229513058.1 LacI family DNA-binding transcriptional regulator -
PTKU64_RS05395 (PTKU64_10590) 1210712..1210954 + 243 WP_007585570.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PTKU64_RS05400 (PTKU64_10600) 1210941..1211231 + 291 WP_042314621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTKU64_RS05405 (PTKU64_10610) 1211345..1211965 + 621 WP_229513060.1 glutathione S-transferase -
PTKU64_RS05410 (PTKU64_10620) 1212186..1212377 + 192 WP_007585578.1 hypothetical protein -
PTKU64_RS05415 (PTKU64_10630) 1212505..1213908 + 1404 WP_229513061.1 FAD-containing oxidoreductase -
PTKU64_RS05420 (PTKU64_10640) 1213920..1214252 + 333 WP_229513063.1 cupin domain-containing protein -
PTKU64_RS05425 (PTKU64_10650) 1214394..1214969 + 576 WP_042314626.1 TMEM175 family protein -
PTKU64_RS05430 (PTKU64_10660) 1214973..1215761 + 789 WP_229513065.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11009.90 Da        Isoelectric Point: 10.5985

>T39848 WP_042314621.1 NZ_AP024955:1210941-1211231 [Paraburkholderia terrae]
MTIYKLQFLESAQKEWSKLDNTVRSQLKRKLAERLENPRVESARLSTMPDCYKIKLAASGYRLVYQVVDRTVTVTVISVG
KRERSAVYAAAIARLM

Download         Length: 291 bp

>T39848 NZ_AP024955:1210941-1211231 [Paraburkholderia terrae]
TTGACGATCTATAAACTGCAGTTTCTTGAATCTGCTCAAAAGGAATGGAGCAAGCTCGATAACACGGTGCGCTCACAGCT
AAAACGCAAGCTGGCCGAACGGCTGGAGAACCCGCGCGTTGAGTCGGCAAGGCTGAGCACGATGCCTGACTGCTACAAAA
TCAAGCTTGCTGCCTCGGGTTACAGACTGGTGTATCAAGTTGTGGATCGTACCGTGACGGTCACGGTGATTTCCGTTGGC
AAGCGCGAAAGAAGCGCAGTCTATGCTGCAGCAATTGCGCGCCTGATGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8657.90 Da        Isoelectric Point: 4.1954

>AT39848 WP_007585570.1 NZ_AP024955:1210712-1210954 [Paraburkholderia terrae]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNKPVAYLIPAAEWEAICERLEDIELAEIVRARSGEKAVSVNLDDL

Download         Length: 243 bp

>AT39848 NZ_AP024955:1210712-1210954 [Paraburkholderia terrae]
ATGGAAAGCATTCTTGCACGCACTTCGATTGGCATCAGCGAGCTCAAGGTCAATCCCACGGCAGCAATTGAGCAGGCAGA
CGGTCCGGTCGCGGTGCTGAATCGAAACAAGCCGGTCGCGTACCTGATCCCTGCGGCCGAATGGGAAGCGATTTGCGAGC
GACTCGAAGATATCGAGCTGGCCGAGATCGTCAGGGCGCGAAGCGGCGAGAAAGCCGTGAGCGTAAATCTTGACGATCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8EI77

Antitoxin

Source ID Structure
AlphaFold DB A0A244DDI0

References