Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 4383..4848 Replicon plasmid pAA2-2d
Accession NZ_AP024932
Organism Thermus thermophilus strain AA2-2

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag LDO10_RS13215 Protein ID WP_223972166.1
Coordinates 4579..4848 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag LDO10_RS13210 Protein ID WP_223972163.1
Coordinates 4383..4595 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO10_RS13190 (TthAA22_26000) 1803..2102 + 300 WP_223972157.1 ribbon-helix-helix protein, CopG family -
LDO10_RS13195 (TthAA22_26010) 2109..2876 + 768 WP_223972160.1 hypothetical protein -
LDO10_RS13435 (TthAA22_26020) 2873..3223 + 351 WP_267461454.1 hypothetical protein -
LDO10_RS13205 (TthAA22_26030) 3369..4205 + 837 WP_143584783.1 IS982 family transposase -
LDO10_RS13210 (TthAA22_26040) 4383..4595 + 213 WP_223972163.1 DUF6290 family protein Antitoxin
LDO10_RS13215 (TthAA22_26050) 4579..4848 + 270 WP_223972166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO10_RS13220 (TthAA22_26060) 5015..5431 + 417 WP_223972169.1 MerR family transcriptional regulator -
LDO10_RS13225 (TthAA22_26070) 5566..6849 + 1284 WP_223972172.1 primase C-terminal domain-containing protein -
LDO10_RS13230 (TthAA22_26080) 7424..8524 - 1101 WP_223972040.1 transposase -
LDO10_RS13235 (TthAA22_26090) 8642..8854 + 213 WP_223972149.1 hypothetical protein -
LDO10_RS13240 (TthAA22_26100) 8851..9120 - 270 WP_038055007.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..13273 13273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-38)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10620.35 Da        Isoelectric Point: 10.3571

>T39840 WP_223972166.1 NZ_AP024932:4579-4848 [Thermus thermophilus]
MGYRIEFDPRAEKELAKLDREVARRILRFLRERVAALEDPRSLGEPLRGPELGKFWKYRVGDYRLICHIQDGEAKVLVLR
VGHRRDVYR

Download         Length: 270 bp

>T39840 NZ_AP024932:4579-4848 [Thermus thermophilus]
TTGGGCTATCGGATTGAGTTCGACCCCCGGGCGGAGAAGGAGCTGGCGAAGCTGGACCGCGAGGTGGCCCGGCGCATCCT
GCGCTTCCTTCGGGAGCGGGTGGCCGCCCTGGAGGACCCCCGCAGCCTCGGGGAGCCCTTGCGCGGGCCGGAGCTGGGGA
AGTTTTGGAAGTACCGGGTGGGGGACTACCGCCTGATCTGCCACATCCAAGACGGGGAGGCCAAGGTCCTGGTGCTGCGG
GTAGGCCACCGCCGGGACGTCTACCGCTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8251.49 Da        Isoelectric Point: 4.8409

>AT39840 WP_223972163.1 NZ_AP024932:4383-4595 [Thermus thermophilus]
MVVVRLPKEIEERLTALARKTGRSKSYYVRQALLEYLDDLEDYYLAVERLEERLPGIPLNEVERRLGLSD

Download         Length: 213 bp

>AT39840 NZ_AP024932:4383-4595 [Thermus thermophilus]
ATGGTGGTCGTCCGTCTGCCCAAGGAGATCGAGGAACGCCTCACGGCCCTTGCCCGGAAGACGGGGCGGAGCAAGAGCTA
CTACGTCCGCCAGGCCCTTCTGGAGTACCTGGACGACCTGGAGGACTACTACCTGGCGGTAGAGCGCCTGGAAGAGCGCC
TTCCCGGCATCCCCCTGAACGAGGTGGAGCGCCGCCTTGGGCTATCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References