Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2060155..2061983 Replicon chromosome
Accession NZ_AP024911
Organism Vibrio zhugei strain KCTC 62784

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCU34_RS09685 Protein ID WP_162808813.1
Coordinates 2060155..2061516 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCU34_RS09690 Protein ID WP_114793718.1
Coordinates 2061501..2061983 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU34_RS09665 2056318..2056704 + 387 WP_030000950.1 transcriptional regulator -
OCU34_RS09670 2056784..2057005 - 222 WP_114793721.1 hypothetical protein -
OCU34_RS09675 2057212..2058591 - 1380 WP_240308482.1 Fic family protein -
OCU34_RS09680 2058874..2059650 + 777 WP_114793720.1 metallophosphoesterase -
OCU34_RS09685 2060155..2061516 + 1362 WP_162808813.1 type II toxin-antitoxin system HipA family toxin Toxin
OCU34_RS09690 2061501..2061983 + 483 WP_114793718.1 helix-turn-helix transcriptional regulator Antitoxin
OCU34_RS09695 2062245..2063558 - 1314 WP_123017299.1 IS4 family transposase -
OCU34_RS09700 2063758..2063922 - 165 WP_164711872.1 hypothetical protein -
OCU34_RS09705 2063933..2064793 - 861 WP_241967670.1 zeta toxin family protein -
OCU34_RS09710 2064824..2064934 - 111 Protein_1840 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2045423..2061983 16560
- flank IS/Tn - - 2064821..2064934 113


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-140)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51398.09 Da        Isoelectric Point: 4.8182

>T39835 WP_162808813.1 NZ_AP024911:2060155-2061516 [Vibrio zhugei]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCLDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T39835 NZ_AP024911:2060155-2061516 [Vibrio zhugei]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCGG
TGTCACTAAACCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACAGGGGCAGGAGGTGAGGCGCCAAAGCTGATCCTCCGATGTGGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGTAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTGTGGCTTCCTCGATTTGACGTTCAAATTAATGAGCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGTATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTCGTAGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAAGTGTTATTACAAGAACTAGAGGTTACTGCAAGTAAATGCCTTGATTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17579.15 Da        Isoelectric Point: 10.8874

>AT39835 WP_114793718.1 NZ_AP024911:2061501-2061983 [Vibrio zhugei]
MGATMNKPSNKESVQDTVARLRAKRNQHQPKTGTDTTHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT39835 NZ_AP024911:2061501-2061983 [Vibrio zhugei]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAAGCGAAATCA
ACATCAGCCCAAGACTGGGACGGATACAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTGAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
CGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AACCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References