Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1053383..1053942 Replicon chromosome
Accession NZ_AP024911
Organism Vibrio zhugei strain KCTC 62784

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OCU34_RS05105 Protein ID WP_123015810.1
Coordinates 1053383..1053661 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OCU34_RS05110 Protein ID WP_123015811.1
Coordinates 1053661..1053942 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU34_RS05080 1048718..1049488 + 771 Protein_929 GNAT family N-acetyltransferase -
OCU34_RS05085 1049617..1050048 + 432 WP_123015809.1 nuclear transport factor 2 family protein -
OCU34_RS05090 1050151..1050321 + 171 Protein_931 AraC family transcriptional regulator -
OCU34_RS05095 1050966..1052077 + 1112 WP_241967546.1 IS3 family transposase -
OCU34_RS05100 1052102..1053144 + 1043 Protein_933 IS3 family transposase -
OCU34_RS05105 1053383..1053661 - 279 WP_123015810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCU34_RS05110 1053661..1053942 - 282 WP_123015811.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OCU34_RS05115 1054392..1054751 + 360 Protein_936 integrase core domain-containing protein -
OCU34_RS05120 1054865..1055203 - 339 WP_123015812.1 cytosolic protein -
OCU34_RS05125 1055292..1055621 - 330 WP_123015813.1 hypothetical protein -
OCU34_RS05130 1055886..1057046 - 1161 WP_123015814.1 MFS transporter -
OCU34_RS05135 1057390..1057869 - 480 WP_123015815.1 hypothetical protein -
OCU34_RS05140 1057859..1058203 - 345 WP_123015816.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1041210..1058203 16993
- inside IScluster/Tn - - 1050966..1054751 3785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10945.54 Da        Isoelectric Point: 4.3430

>T39834 WP_123015810.1 NZ_AP024911:c1053661-1053383 [Vibrio zhugei]
MIYWEEESLNDREKIFEFLYDFNPDVAERTDDIIEAKVENLNEQPLMGVQRDGIRGRLLIIPEVSMIVSYFVDGSNIRIM
RVLHQKQKFPIE

Download         Length: 279 bp

>T39834 NZ_AP024911:c1053661-1053383 [Vibrio zhugei]
ATGATTTACTGGGAAGAAGAGTCTTTAAACGACCGAGAAAAAATCTTTGAGTTTCTGTACGATTTTAACCCTGATGTAGC
TGAAAGAACCGACGACATTATTGAAGCCAAAGTTGAAAACCTAAATGAACAACCGTTAATGGGAGTTCAACGTGATGGCA
TTCGAGGTCGATTACTCATTATTCCTGAAGTATCAATGATCGTTTCGTATTTTGTCGATGGTTCTAATATTCGAATTATG
CGTGTTCTTCATCAAAAGCAAAAATTCCCAATTGAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10767.03 Da        Isoelectric Point: 9.2520

>AT39834 WP_123015811.1 NZ_AP024911:c1053942-1053661 [Vibrio zhugei]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRDLTEQLAEQQRKALSHDAWLTEQVNLAFDKFDSGRAVFVDHESAKNR
MASRKAKIRNRGQ

Download         Length: 282 bp

>AT39834 NZ_AP024911:c1053942-1053661 [Vibrio zhugei]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGTTTAGCCCAACAAATGGCTGAAAGCCAAGGTCGAAC
GCTTAGTGATGCTTGCCGTGACCTCACCGAACAACTCGCTGAACAACAACGTAAAGCATTATCCCATGATGCTTGGCTAA
CTGAACAAGTTAATCTCGCATTTGATAAATTTGACTCTGGGCGAGCTGTATTCGTTGACCATGAATCAGCCAAAAATCGT
ATGGCTTCTCGCAAAGCAAAAATCCGTAACCGGGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References