Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 291893..292410 Replicon chromosome
Accession NZ_AP024908
Organism Vibrio spartinae strain CECT 9026

Toxin (Protein)


Gene name relB Uniprot ID A0A1N6LZR2
Locus tag OCU60_RS19165 Protein ID WP_074371254.1
Coordinates 292141..292410 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1N6LZQ8
Locus tag OCU60_RS19160 Protein ID WP_074371255.1
Coordinates 291893..292144 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU60_RS19125 287302..287880 + 579 WP_074371262.1 hypothetical protein -
OCU60_RS19130 287986..288459 + 474 WP_074371261.1 GrpB family protein -
OCU60_RS19135 288618..289220 + 603 WP_074371260.1 hypothetical protein -
OCU60_RS19140 289353..289991 + 639 WP_139302084.1 hypothetical protein -
OCU60_RS19145 290129..290599 + 471 WP_074371258.1 dual specificity protein phosphatase family protein -
OCU60_RS19150 290675..291151 + 477 WP_074371257.1 GNAT family N-acetyltransferase -
OCU60_RS19155 291290..291745 + 456 WP_074371256.1 hypothetical protein -
OCU60_RS19160 291893..292144 + 252 WP_074371255.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OCU60_RS19165 292141..292410 + 270 WP_074371254.1 Txe/YoeB family addiction module toxin Toxin
OCU60_RS19170 292552..293055 + 504 WP_074371253.1 peptide deformylase -
OCU60_RS19175 293158..293655 + 498 WP_021020996.1 GNAT family N-acetyltransferase -
OCU60_RS19180 294091..294969 + 879 WP_139302083.1 alpha/beta hydrolase fold domain-containing protein -
OCU60_RS19185 295007..295753 + 747 WP_074371251.1 carbon-nitrogen hydrolase family protein -
OCU60_RS19190 295806..296606 + 801 WP_159439430.1 signal peptidase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10633.07 Da        Isoelectric Point: 9.4821

>T39833 WP_074371254.1 NZ_AP024908:292141-292410 [Vibrio spartinae]
MSSSQRLLSWTDESWNDRLYWQIQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T39833 NZ_AP024908:292141-292410 [Vibrio spartinae]
ATGAGTAGTAGCCAGCGATTGCTTTCATGGACTGATGAATCTTGGAATGATCGTTTATATTGGCAAATACAAGATAAAAA
GACATTGAAGCGTATAAATAAATTAATTAATGATGTAAAACGTTCACCATTTGAAGGTATCGGAAAGCCCGAACCATTAA
AAGAAAATCTAGCCGGCTTTTGGTCACGCCGTATTGACGACACTAACCGATTAGTTTATGCGGTTGATGACCAAGCTATC
ACAATTATTTCATGTCGTTATCATTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9288.41 Da        Isoelectric Point: 5.6400

>AT39833 WP_074371255.1 NZ_AP024908:291893-292144 [Vibrio spartinae]
MKIVSFTEARNSLKAVLDGVVNDADTTVITRRDAEDAVVMSLDYYNSLMETVHLLRSPENAEHLNRSIAQYRAGQTTRSI
FNG

Download         Length: 252 bp

>AT39833 NZ_AP024908:291893-292144 [Vibrio spartinae]
ATGAAAATTGTATCCTTTACGGAAGCGAGAAATAGTTTAAAAGCTGTTCTCGATGGTGTCGTGAATGATGCTGATACAAC
AGTAATTACTCGTCGTGATGCAGAGGATGCAGTCGTCATGTCCTTGGATTACTACAATAGCTTGATGGAAACCGTTCATT
TACTTCGTTCTCCAGAAAACGCAGAGCATCTAAATCGTTCGATCGCTCAATATCGTGCAGGTCAAACAACCCGCTCGATA
TTTAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1N6LZR2

Antitoxin

Source ID Structure
AlphaFold DB A0A1N6LZQ8

References