Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 284904..285556 Replicon chromosome
Accession NZ_AP024908
Organism Vibrio spartinae strain CECT 9026

Toxin (Protein)


Gene name hicA Uniprot ID A0A1N6LZR6
Locus tag OCU60_RS19110 Protein ID WP_074371264.1
Coordinates 284904..285083 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M4V002
Locus tag OCU60_RS19115 Protein ID WP_021021012.1
Coordinates 285143..285556 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU60_RS19075 280035..280238 + 204 WP_074371266.1 4-oxalocrotonate tautomerase family protein -
OCU60_RS19080 280388..280693 + 306 WP_074371265.1 YkgJ family cysteine cluster protein -
OCU60_RS19085 281505..282170 + 666 Protein_257 glycoside hydrolase family 11 protein -
OCU60_RS19090 282231..283181 + 951 WP_261854761.1 polysaccharide deacetylase family protein -
OCU60_RS19095 283586..283933 + 348 WP_074371307.1 cupin domain-containing protein -
OCU60_RS19100 284009..284194 + 186 WP_162493844.1 hypothetical protein -
OCU60_RS19105 284220..284501 + 282 WP_182288787.1 hypothetical protein -
OCU60_RS19110 284904..285083 + 180 WP_074371264.1 type II toxin-antitoxin system HicA family toxin Toxin
OCU60_RS19115 285143..285556 + 414 WP_021021012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCU60_RS19120 285844..286725 + 882 WP_074371263.1 HEPN domain-containing protein -
OCU60_RS19125 287302..287880 + 579 WP_074371262.1 hypothetical protein -
OCU60_RS19130 287986..288459 + 474 WP_074371261.1 GrpB family protein -
OCU60_RS19135 288618..289220 + 603 WP_074371260.1 hypothetical protein -
OCU60_RS19140 289353..289991 + 639 WP_139302084.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6663.87 Da        Isoelectric Point: 11.0775

>T39832 WP_074371264.1 NZ_AP024908:284904-285083 [Vibrio spartinae]
VKSADLINLLKKNGWELVSVRGSHHKFRHPAHDDPIIVPHPKKDLKIGLVNKIKRQAGL

Download         Length: 180 bp

>T39832 NZ_AP024908:284904-285083 [Vibrio spartinae]
GTGAAAAGTGCAGACTTAATTAATCTCTTGAAAAAGAACGGGTGGGAGTTAGTCAGTGTCAGAGGAAGTCATCACAAGTT
CCGACATCCAGCTCATGATGATCCGATCATTGTTCCACATCCCAAAAAAGATTTAAAAATTGGGTTGGTCAACAAAATAA
AGAGACAAGCGGGGCTGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15259.33 Da        Isoelectric Point: 4.5544

>AT39832 WP_021021012.1 NZ_AP024908:285143-285556 [Vibrio spartinae]
MLYPIAIDTGDKEHAYGVTFPDLPGCFSAGDTLDEALLNAKDAAEFYLEDLAEHGKLPPKAGDLSTWQKDPEYLGWAWAV
VDIDVEPFLGKSIKINATLPTLYLKKIDDLVKVHPEYKNRSHFLQIAATHEFEKLAG

Download         Length: 414 bp

>AT39832 NZ_AP024908:285143-285556 [Vibrio spartinae]
ATGTTATATCCCATTGCAATTGATACCGGCGATAAGGAACATGCTTACGGCGTGACGTTTCCCGATTTACCCGGATGTTT
CTCAGCCGGAGATACCTTGGATGAAGCATTGTTAAACGCAAAAGACGCGGCTGAGTTTTATTTAGAAGATTTGGCTGAAC
ACGGTAAATTACCACCGAAAGCGGGTGATCTTTCGACGTGGCAAAAAGACCCGGAATATCTCGGGTGGGCTTGGGCTGTT
GTTGATATTGATGTTGAGCCGTTTTTGGGGAAATCCATTAAGATTAATGCAACGCTCCCGACCCTTTACCTGAAAAAGAT
CGATGATTTGGTCAAGGTTCATCCAGAGTACAAAAACCGTTCACATTTCTTACAAATTGCTGCTACGCATGAGTTTGAAA
AGCTGGCCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1N6LZR6

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4V002

References