Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1334807..1335366 Replicon chromosome
Accession NZ_AP024907
Organism Vibrio spartinae strain CECT 9026

Toxin (Protein)


Gene name relE Uniprot ID A0A1N6M707
Locus tag OCU60_RS06055 Protein ID WP_074373718.1
Coordinates 1334807..1335085 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1N6M774
Locus tag OCU60_RS06060 Protein ID WP_074373719.1
Coordinates 1335085..1335366 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU60_RS06035 1329880..1330821 - 942 WP_074373714.1 diguanylate cyclase -
OCU60_RS06040 1331151..1332305 - 1155 WP_074373715.1 PLP-dependent aminotransferase family protein -
OCU60_RS06045 1332447..1333316 + 870 WP_074373716.1 helix-turn-helix domain-containing protein -
OCU60_RS06050 1333551..1334303 + 753 WP_074373717.1 methyltransferase domain-containing protein -
OCU60_RS06055 1334807..1335085 - 279 WP_074373718.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
OCU60_RS06060 1335085..1335366 - 282 WP_074373719.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OCU60_RS06065 1335757..1336086 + 330 WP_074373721.1 putative quinol monooxygenase -
OCU60_RS06070 1337172..1337678 - 507 WP_074373723.1 ankyrin repeat domain-containing protein -
OCU60_RS06075 1337675..1339237 - 1563 WP_074373724.1 S-type pyocin domain-containing protein -
OCU60_RS06080 1339406..1339609 - 204 WP_059122514.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-44)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10979.51 Da        Isoelectric Point: 4.2597

>T39830 WP_074373718.1 NZ_AP024907:c1335085-1334807 [Vibrio spartinae]
MIYWEEESLNDREKIFEFLYDFNPDVAERTDDIIEAKVENLNDQPLMGVQRDGIRGRLLIISEVSMIVSYFVDDSNIRIM
RVLHQKQKFPIE

Download         Length: 279 bp

>T39830 NZ_AP024907:c1335085-1334807 [Vibrio spartinae]
ATGATTTACTGGGAAGAAGAATCTTTAAATGACCGCGAAAAAATCTTTGAATTTCTATATGATTTTAACCCTGATGTCGC
AGAAAGAACCGACGACATTATTGAAGCTAAAGTTGAAAACCTTAACGATCAACCATTAATGGGTGTTCAACGTGATGGAA
TTCGAGGTCGATTACTTATCATTTCTGAAGTATCAATGATCGTTTCGTACTTTGTCGATGATTCTAATATTCGTATTATG
CGAGTTCTTCATCAAAAGCAAAAATTCCCAATTGAGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10751.03 Da        Isoelectric Point: 9.2520

>AT39830 WP_074373719.1 NZ_AP024907:c1335366-1335085 [Vibrio spartinae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDGWLTEQVNLAFDKFDSGRAVFVDHESAKNR
MAARKAKIRNRGQ

Download         Length: 282 bp

>AT39830 NZ_AP024907:c1335366-1335085 [Vibrio spartinae]
ATGGATACCAGAATTCAGTTTCGTGTTGATGAAGAAACAAAACGTTTAGCCCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGTGACGCTTGCCGCGAACTCACTGAACAGCTAGCAGAACAACAACGTAAAGCATTATCCCACGATGGTTGGCTTA
CTGAACAAGTTAATCTCGCATTTGACAAATTTGATTCTGGCCGTGCTGTGTTTGTTGACCATGAGTCTGCCAAAAATCGC
ATGGCTGCACGCAAAGCTAAAATTCGTAATCGAGGTCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1N6M707

Antitoxin

Source ID Structure
AlphaFold DB A0A1N6M774

References