Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 972756..974605 Replicon chromosome
Accession NZ_AP024907
Organism Vibrio spartinae strain CECT 9026

Toxin (Protein)


Gene name hipA Uniprot ID A0A1N6M8C1
Locus tag OCU60_RS04545 Protein ID WP_074374186.1
Coordinates 973256..974605 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1N6M8G1
Locus tag OCU60_RS04540 Protein ID WP_074374187.1
Coordinates 972756..973259 (-) Length 168 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU60_RS04525 968005..969384 + 1380 WP_235862212.1 Fic family protein -
OCU60_RS04530 969839..971125 + 1287 WP_074374189.1 hypothetical protein -
OCU60_RS04535 971526..972269 + 744 WP_074374188.1 metallophosphoesterase -
OCU60_RS04540 972756..973259 - 504 WP_074374187.1 helix-turn-helix transcriptional regulator Antitoxin
OCU60_RS04545 973256..974605 - 1350 WP_074374186.1 HipA domain-containing protein Toxin
OCU60_RS04550 974921..975169 - 249 WP_074374185.1 type II toxin-antitoxin system antitoxin HipB -
OCU60_RS04565 977131..977610 - 480 WP_074374182.1 SsrA-binding protein SmpB -
OCU60_RS04570 977831..978262 + 432 WP_074374181.1 SRPBCC family protein -
OCU60_RS04575 978259..978606 + 348 WP_074374180.1 RnfH family protein -
OCU60_RS04580 978676..979038 - 363 WP_074374179.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-396)

Antitoxin

Cro/C1-type helix-turn-helix domain

(96-147)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51387.22 Da        Isoelectric Point: 4.9885

>T39829 WP_074374186.1 NZ_AP024907:c974605-973256 [Vibrio spartinae]
MESLTIQAYILEQWIDIAHVTFPKSNEGNFIITEVHYLNEYAVENFEKDDNHAVSLNHPVNFYFDDKGRSGWLRFLDDIM
PSGASRRYWVKQLDIGDLAIDQQDFILLKYGTISPVGNLRIKESLPKRTKKSDSLSFALHDVIDRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRYSNEGRIWIDSYQDDVTNQDLHYLVKYPRGSRGKTDSNILRAEYYYYHELTSMGVDTIPIESMR
LEEGENYPSLWLPRFDIYLDDKQNMQRYAMESVYSILNKGPGSLLDHEDTIRQLIDKIMNSHMVTEQGYQFNIQEFVIEW
VKRDLLNIIFGNSDNHGRNTSFIKKEGFIKLAPVYDFAPMKADPEGIPRATKWKSPLEVGGEYDFYGIATSLSDLVPKET
LLKELKALAQNCLTLKERLEERGTPKQILDMPGIGMDFIATKLGKWGLI

Download         Length: 1350 bp

>T39829 NZ_AP024907:c974605-973256 [Vibrio spartinae]
ATGGAATCACTCACTATACAAGCTTACATACTGGAGCAATGGATTGATATAGCTCACGTTACCTTCCCTAAGAGTAATGA
AGGCAACTTCATAATCACAGAAGTTCATTACCTAAACGAATATGCTGTAGAAAACTTCGAGAAAGATGACAACCATGCCG
TTTCACTTAATCACCCTGTTAATTTCTACTTTGACGATAAAGGGCGCTCGGGGTGGCTGAGGTTTCTCGATGACATAATG
CCGAGTGGAGCGAGCAGACGTTACTGGGTCAAGCAACTTGATATTGGAGATCTAGCTATTGACCAGCAAGATTTCATCCT
TTTAAAGTATGGAACTATCTCTCCAGTTGGTAATTTGAGAATAAAGGAATCATTACCAAAGCGGACTAAAAAATCAGATT
CACTGTCCTTCGCCCTTCATGATGTAATCGATAGAGCTAGTGACTTCTTAGATTACGCGCAAGAAAGGGGAGCTGCTGCT
GGAGGTGCCACAGGTGCTGGAGGAGAAGCTCCAAAACTACTACTGCGTTACTCCAACGAGGGGCGGATCTGGATTGACAG
CTATCAAGATGACGTTACTAATCAAGATTTACATTATCTAGTAAAATATCCGCGAGGCTCTAGAGGGAAAACTGACAGCA
ATATTTTACGAGCTGAATATTATTATTATCATGAGTTAACAAGCATGGGAGTCGATACTATTCCAATAGAATCGATGCGA
TTAGAAGAAGGTGAAAATTACCCCTCTCTCTGGTTACCAAGGTTTGATATCTATTTAGATGACAAGCAAAACATGCAGCG
CTATGCCATGGAGTCGGTTTACTCAATTTTAAATAAAGGACCAGGTAGTCTTCTTGATCATGAAGATACTATTAGACAAC
TGATTGATAAAATCATGAATAGTCATATGGTTACTGAACAAGGCTATCAGTTTAACATCCAAGAATTTGTTATTGAATGG
GTAAAAAGGGACTTGCTCAATATCATATTTGGCAACAGCGATAACCATGGAAGAAACACTTCTTTCATCAAAAAAGAAGG
TTTTATCAAACTTGCTCCAGTCTATGATTTTGCTCCAATGAAAGCAGACCCTGAAGGGATACCTAGAGCTACCAAGTGGA
AATCACCTTTAGAGGTAGGAGGTGAGTATGATTTTTACGGTATCGCAACTTCACTGTCAGATTTAGTTCCCAAAGAGACT
CTATTAAAAGAACTTAAAGCGCTTGCACAAAACTGTCTTACTTTAAAAGAAAGGTTAGAAGAAAGAGGAACACCAAAGCA
GATTTTGGATATGCCTGGTATAGGTATGGATTTCATTGCGACAAAACTTGGTAAATGGGGGCTGATATGA

Antitoxin


Download         Length: 168 a.a.        Molecular weight: 18728.56 Da        Isoelectric Point: 10.4867

>AT39829 WP_074374187.1 NZ_AP024907:c973259-972756 [Vibrio spartinae]
MSSNTDSLNRLDRLSLNTSAESVHDAISRLRLNKEHLSAAITIQKEHAQTSIDQIEKVAKRTPKNVQPISVSERKHKINR
VIRSLLMNELTQGFALKELRINVLGVKQDTFAKMVGVSRKTISEIENDRGTFKTDILDKVFKPFGLKVGLVPISTNLLNS
ALNCHDE

Download         Length: 504 bp

>AT39829 NZ_AP024907:c973259-972756 [Vibrio spartinae]
ATGAGTTCTAACACCGACAGTTTAAACCGATTAGATCGGCTTTCTCTAAACACTTCGGCAGAATCTGTACATGATGCAAT
CTCCCGACTTCGTTTGAATAAAGAACACTTAAGTGCAGCAATTACAATACAAAAAGAGCATGCTCAAACCTCGATTGATC
AGATTGAAAAAGTGGCAAAGCGTACGCCTAAAAACGTACAACCAATATCAGTATCCGAAAGAAAACATAAGATAAATAGA
GTTATTAGATCGTTGCTTATGAATGAACTAACACAAGGATTCGCTCTCAAGGAGCTTAGGATAAACGTGTTAGGTGTCAA
ACAAGATACCTTTGCCAAAATGGTTGGGGTTTCCAGAAAAACTATATCTGAGATTGAGAATGATCGAGGTACTTTCAAAA
CTGATATTCTCGATAAAGTATTCAAGCCATTTGGACTAAAAGTAGGGCTAGTACCAATATCGACTAACCTACTAAATTCC
GCACTTAACTGTCATGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1N6M8C1

Antitoxin

Source ID Structure
AlphaFold DB A0A1N6M8G1

References