Detailed information of TA system TA039828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 935061..935583
• Replicon: chromosome
• Accession: NZ_AP024906
• Organism: Vibrio ruber strain LMG 23124

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCU42_RS19120
• Protein ID: WP_077334614.1
• Coordinates: 935061..935345 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1R4LGV6
• Locus tag: OCU42_RS19125
• Protein ID: WP_038184259.1
• Coordinates: 935335..935583 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU42_RS19100	930420..931496	+	1077	WP_077334606.1	dsDNA nuclease domain-containing protein	-
OCU42_RS19105	931489..933234	+	1746	WP_077334608.1	hypothetical protein	-
OCU42_RS19110	933643..933918	+	276	WP_077334610.1	antibiotic biosynthesis monooxygenase	-
OCU42_RS19115	934054..934935	+	882	WP_077334612.1	HEPN domain-containing protein	-
OCU42_RS19120	935061..935345	-	285	WP_077334614.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCU42_RS19125	935335..935583	-	249	WP_038184259.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCU42_RS19130	935891..937111	+	1221	WP_077334616.1	aldose 1-epimerase family protein	-
OCU42_RS19135	937283..938767	-	1485	WP_077334618.1	methyl-accepting chemotaxis protein	-
OCU42_RS19140	938777..939304	-	528	WP_077334620.1	PAS domain-containing protein	-
OCU42_RS19145	939542..940456	+	915	WP_205409431.1	homocysteine S-methyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-72)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11103.10 Da
• Isoelectric Point: 10.7224

>T39828 WP_077334614.1 NZ_AP024906:c935345-935061 [Vibrio ruber]
MTYKLEFKKSALKEWEKLGSTLQQQFKKKLIERLENPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRR

Nucleotide

• Length: 285 bp

>T39828 NZ_AP024906:c935345-935061 [Vibrio ruber]
ATGACCTATAAACTTGAATTCAAAAAGAGTGCACTCAAAGAGTGGGAAAAGCTTGGTTCAACGCTGCAACAGCAATTTAA
GAAAAAGCTGATTGAGCGATTAGAGAACCCGCATGTGCCAGCCTCAAAACTTTCTGGCGCTGACAATATGTACAAAATAA
AATTGCGCCAATCGGGTTACCGCTTAGTCTACAAAGTCGAAGACGATGTCATTATTGTCACCGTCTTAGCCGTCGGCAAG
CGCGAGCGTAGTGATGTTTACCGTAAGGCGATGAAACGGCGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9060.40 Da
• Isoelectric Point: 4.0653

>AT39828 WP_038184259.1 NZ_AP024906:c935583-935335 [Vibrio ruber]
MTSKILADVAASITELKANPMKVATSAYGEPVAVLNRNEPVFYCVPAEAYEMMMDKLEDLELLAIAKERESEESISVHID
DL

Nucleotide

• Length: 249 bp

>AT39828 NZ_AP024906:c935583-935335 [Vibrio ruber]
ATGACCTCTAAAATTTTGGCTGATGTTGCTGCCAGTATTACTGAGTTAAAAGCAAACCCGATGAAAGTTGCAACAAGTGC
TTACGGTGAACCGGTCGCTGTACTCAACCGAAATGAGCCAGTATTTTATTGCGTACCCGCTGAAGCGTACGAAATGATGA
TGGATAAACTCGAAGATCTTGAGCTACTTGCTATTGCGAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTTCATATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1R4LGV6